Protein Alignment repo and PITX1

DIOPT Version :9

• Sequence 1: NP_477026.1
• Gene: repo / 47285
• FlyBaseID: FBgn0011701
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_002644.4
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 314
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 98/395 - (24%)
• Similarity: 138/395 - (34%)
• Gaps: 164/395 - (41%)

  Fly   133 PPPSHNGILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSPHHLD 197
            |||.|:                            .|...:.:.|.|..||
Human    21 PPPPHD----------------------------MGPAFHLARPADPREP--------------- 42

  Fly   198 HLDHGSDGLLQDSSPVMINGGSAGGKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGNAN 262
             |::.:    .:||...:.....||:.|.|::       .|||                |||
Human    43 -LENSA----SESSDTELPEKERGGEPKGPED-------SGAG----------------GTG--- 76

  Fly   263 SSSSAGVGIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAP 327
                           .||...||.||              |:::.||.||:.||:|||..|:|..
Human    77 ---------------CGGADDPAKKK--------------KQRRQRTHFTSQQLQELEATFQRNR 112

  Fly   328 YPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPR-----KTGYI---------------- 371
            |||:..|||:|:..||:|.||:|||:||||||||.|..:     |.||:
Human   113 YPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAA 177

  Fly   372 ---------KTSTP-PTAT--------LNPGTLAPPFTSYPQTTTVTPPGSMDSWTSYQTP---- 414
                     |:..| |.:|        ::|.:....|::....:::|.|.||........|
Human   178 GYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPNSGL 242

  Fly   415 ---YELTPQF--SLLSPAASPYGTYSGQYGAY--VHESQLFPMR-----HYEYGSPTRMEMGATT 467
               ..||...  |.:||.|.||||.:..|..|  ...|.|..:|     |..:|      .|...
Human   243 NNINNLTGSSLNSAMSPGACPYGTPASPYSVYRDTCNSSLASLRLKSKQHSSFG------YGGLQ 301

  Fly   468 GSVAG 472
            |..:|
Human   302 GPASG 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	27/46 (59%)
PITX1	NP_002644.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		35/184 (19%)
		COG5576	36..>146	CDD:227863	56/184 (30%)
		Homeobox	93..146	CDD:395001	32/52 (62%)
		Interaction with PIT-1. /evidence=ECO:0000250	147..279		27/131 (21%)
		OAR	276..293	CDD:397759	3/16 (19%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	280..293		3/12 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	286..290		1/3 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940