Protein Alignment repo and OTX2

DIOPT Version :10

• Sequence 1: NP_477026.1
• Gene: repo / 47285
• FlyBaseID: FBgn0011701
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Alignment Length: 272
• Identity: 86/272 - (31%)
• Similarity: 120/272 - (44%)
• Gaps: 68/272 - (25%)

  Fly   243 PPSSSSTVVNG---TTNGTGNANSSSSAGVGIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKK 304
            ||.:    |||   ||:|....:.|    ||..|.     ..:.|||           .|.  |:
Human     8 PPYA----VNGLSLTTSGMDLLHPS----VGYPGP-----WASCPAA-----------TPR--KQ 46

  Fly   305 KKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTG 369
            ::.|||||..||:.||..|.:..|||:|.|||:|:|:||.||||||||:|||||.|:.:..::.|
Human    47 RRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNG 111

  Fly   370 ------YIKTSTPPTATLN-----PGTLAPP-FTSYPQTTTVTPPGSMDSWTSYQTPYELTPQFS 422
                  ..|..|.|...::     .|...|| .||.|...:.:.|.|:  |    :|..::|...
Human   112 GQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSI--W----SPASISPLSD 170

  Fly   423 LLSPAAS--------PYGTYSGQYGAYVHESQLF----------PMRHYEYG-SPTRMEMGATTG 468
            .||.::|        .|...||....|...:..|          ||.|...| ..|...||  |.
Human   171 PLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMG--TN 233

  Fly   469 SVAGNGDESVAN 480
            :|..:.::|.|:
Human   234 AVTSHLNQSPAS 245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeodomain	313..361	CDD:459649	29/47 (62%)
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	34/54 (63%)
		TF_Otx	161..242	CDD:427350	19/82 (23%)