DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and Arx

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001093644.1	Gene:	Arx / 317268	RGDID:	1562672	Length:	566	Species:	Rattus norvegicus

Alignment Length:	392	Identity:	117/392 - (29%)
Similarity:	159/392 - (40%)	Gaps:	120/392 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 KDQYEPQQLQHLYGGSPHHLDHLDHGSDGLLQDSSPVMINGGSAGGKLKKPDEMCSQLEAGGAGV 241
            :|:.|.::|             |:...:.||:|.:..:         ||:| ..||.
  Rat   234 EDEDEEEEL-------------LEDDEEELLEDDARAL---------LKEP-RRCSV-------- 267

  Fly   242 TPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAGTAGGVAAP----------AAKKDGSS---- 292
                        .|.||..|.::::|..   .|..|.||..:|          |..|||..
  Rat   268 ------------ATTGTVAAAAAAAAAA---AAVATEGGELSPKEELLLHPEDAEGKDGEDSVCL 317

  Fly   293 SKKKGDPNGIKKKKT---RTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQN 354
            |.......|:.|:|.   |||||:||||||||||::..|||||.|||||::|:|:|:||||||||
  Rat   318 SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQN 382

  Fly   355 RRAKWRKHEPPRKTGYIKTSTPPTATLNPGTLAP--PFTSYPQTTTVTP--PGSMDSWT------ 409
            |||||||.|   |.|   ..|.|.....||.|:.  |.:.|...:...|  |....:||
  Rat   383 RRAKWRKRE---KAG---AQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAA 441

  Fly   410 -----SYQTPYELTPQFSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYEYGSPTRMEMGAT--- 466
                 |...|    |..:.|.|:.:|.| .|...||.|       .||..:.||....:.:|
  Rat   442 AAAFPSLPPP----PGSASLPPSGAPLG-LSTFLGAAV-------FRHPAFISPAFGRLFSTMAP 494

  Fly   467 --------------TGSVAGNGDESVANGGSYQTAELQTAQQQQLADGTLVTVHAHQQQQQQQQQ 517
                          |.:|.|    :||:|.   .|:..||...:.|..........::...|..|
  Rat   495 LTSASTAAALLRQPTPAVEG----AVASGA---LADPATAAADRRASSIAALRLKAKEHAAQLTQ 552

  Fly   518 LN 519
            ||
  Rat   553 LN 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	35/46 (76%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..264		10/52 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319		8/32 (25%)
		Homeobox	336..388	CDD:278475	40/51 (78%)
		OAR	530..547	CDD:281777	1/16 (6%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	534..547		0/12 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010