DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and Vsx2

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001284897.1	Gene:	Vsx2 / 31469	FlyBaseID:	FBgn0263512	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	621	Identity:	147/621 - (23%)
Similarity:	198/621 - (31%)	Gaps:	271/621 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 ISAPQKLVEQQQQQQ-----HHHQHHQHYTATPPPSHNGILLHKQSSQQQQQQQQQLVGILDYHP 165
            :|.||:..:||||:|     ||||:.:|:..|...:......:..::........||...:.:|.
  Fly    76 VSEPQQQPQQQQQEQQHHQPHHHQYREHHQMTMAAASRMAYFNAHAAVAAAFMPHQLAAAVHHHH 140

  Fly   166 LNGKLDYSSSPKDQYEPQQLQHLYGGSPHHLDHLDHGSDGLLQDSSPVMINGGSAGGKLKKPD-- 228
                                ||.:...|||..|..|                |:.||....|.
  Fly   141 --------------------QHQHQHHPHHHPHHPH----------------GAVGGPPPPPPMQ 169

  Fly   229 --------------EMCSQLE--AGGAGVTPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAGT 277
                          :...||:  |.|||...|.|.:....|       ..|.:..|||
  Fly   170 HHHPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGSLAPKDFG-------MESLNGFGVG------- 220

  Fly   278 AGGVAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLN 342
                  |.:||     |||      |::.:||.||:||||:||.||:.|.||||:|||.|::|..
  Fly   221 ------PNSKK-----KKK------KRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTE 268

  Fly   343 LSESRVQVWFQNRRAKWRK----------------------HEPPRKTGYIKTS----------- 374
            |.|.|:|||||||||||||                      |..|.....:|::
  Fly   269 LPEDRIQVWFQNRRAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLL 333

  Fly   375 -------------------------------------------------TPPTATLNPGTLAPPF 390
                                                             :..|.:||  .::|..
  Fly   334 GMEQKCMHRKSIEAQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLN--VVSPAP 396

  Fly   391 TSYP-QTTTVTPPGSMDSWTSYQTPYELTPQFSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYE 454
            :|.| ..:|..||.|...:....:....||.                  ||....|...|  |.|
  Fly   397 SSCPTSASTSAPPTSTSGYAGAASSAATTPT------------------GASTTNSSSSP--HIE 441

  Fly   455 YGSPTRMEMGATTGSVAGNGDESVANGGSYQTAELQTAQQQQLADGTLVTVHAHQQQQQQQQQLN 519
            .|||                                :.||||           |.|.||||||..
  Fly   442 LGSP--------------------------------SPQQQQ-----------HLQLQQQQQQQA 463

  Fly   520 GKYLSAEEAKYVHLQCHQSGGGLELSPGA---SCHLVEAQGQHYVTTATGGAASAGGTSSDDNDS 581
            ..||.|                     ||   .|    |...::.......||.||..:|..:..
  Fly   464 SLYLGA---------------------GAVVTGC----APPSYHPLLDAANAAGAGAAASSKDFH 503

  Fly   582 GGMQTVI-----KSEEVSQQQQQQQGQSYVLPPFLH 612
            ..|.|.:     .:::..|||||||.|:....|.||
  Fly   504 MIMNTAVAAAAAAAQQQHQQQQQQQQQATATAPGLH 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	31/46 (67%)
Vsx2	NP_001284897.1	Homeobox	233..286	CDD:278475	35/52 (67%)
Vsx2	NP_001284897.1	OAR	556..570	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450967
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840