DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and Alx1

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_766141.1	Gene:	Alx1 / 216285	MGIID:	104621	Length:	326	Species:	Mus musculus

Alignment Length:	373	Identity:	97/373 - (26%)
Similarity:	141/373 - (37%)	Gaps:	117/373 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 QHYTATPPPSHN--------GILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQ 183
            :.:....|||.|        |.|.|             ::..||.....||....
Mouse     6 EKFALKSPPSKNSDFYMGTGGALEH-------------VMETLDNESFYGKATAG---------- 47

  Fly   184 QLQHLYGGSP---HHLDHLDHGSDGLLQDSSP----VMINGGSAGGKLKKPDEMCSQLEAGGAGV 241
            :....:|..|   ||: .||..|.  .||||.    ..:.|.....:|.:..:.|:.|.......
Mouse    48 KCVQAFGPLPRAEHHV-RLDRTSP--CQDSSVNYGITKVEGQPLHTELNRAMDNCNNLRMSPVKG 109

  Fly   242 TPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAGTAGGVAAPAAKKDGSSSKKKGDPNGIKKKK 306
            .|..|....:....    ::|.|||                                    ||::
Mouse   110 MPEKSELDELGDKC----DSNVSSS------------------------------------KKRR 134

  Fly   307 TRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKWRKHEPPRKTGYI 371
            .|||||:.||||||:.|::..||||:.||:||::..|:|:|||||||||||||||.|   :.|.|
Mouse   135 HRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRE---RYGQI 196

  Fly   372 KTSTPPTATLNPGTLAPPFTSYPQ----------------TTTVTPPGSMDSWTSYQTPYELTPQ 420
            :.:....|.....::.|...||||                |:.:.|..:    :|..|||..:|:
Mouse   197 QQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDA----SSCMTPYSHSPR 257

  Fly   421 FSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYEYGSPTRMEMGATTG 468
                  ..|.|..:|.....:.|    .|:.::...|   :..|||.|
Mouse   258 ------TDSSYTGFSNHQNQFSH----VPLNNFFTDS---LLTGATNG 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	29/46 (63%)
Alx1	NP_766141.1	Homeobox	135..189	CDD:395001	35/53 (66%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		25/118 (21%)
		OAR	302..320	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970