DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and Pax3

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_001152992.1	Gene:	Pax3 / 18505	MGIID:	97487	Length:	484	Species:	Mus musculus

Alignment Length:	508	Identity:	129/508 - (25%)
Similarity:	183/508 - (36%)	Gaps:	149/508 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPPSHN----GILLHKQSSQQQQQQQQQLVGILDYHPLNGKLDYSSSPKDQYEPQQLQHLYGGSP 193
            |.|..|    |..| :.|:...|.:..||.|:.    :||:      |.    |..::|......
Mouse    14 PGPGQNYPRSGFPL-EVSTPLGQGRVNQLGGVF----INGR------PL----PNHIRHKIVEMA 63

  Fly   194 HH---------LDHLDHG--SDGLLQDSSPVMINGGSAGG------------------------- 222
            ||         ...:.||  |..|.:......|..|:.||
Mouse    64 HHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGM 128

  Fly   223 -------KLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTNGTGN-----------ANSSSSAGV 269
                   ||.| |.:|.:      ...|..||.:.:..:..|.|.           ..|...|..
Mouse   129 FSWEIRDKLLK-DAVCDR------NTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKH 186

  Fly   270 GIQGAAGTAGGVAAPAAKKDGSSSKKKGD-PNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFA 333
            .|.|.....  .:||.: .:||....:.| |...|::::||||||.|||||||||||..|||::.
Mouse   187 SIDGILSER--ASAPQS-DEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYT 248

  Fly   334 REELAIKLNLSESRVQVWFQNRRAKWRKHE----------------PP-----------RKTGYI 371
            |||||.:..|:|:||||||.||||:|||..                ||           .:|.|.
Mouse   249 REELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQ 313

  Fly   372 KTSTP-----PTATLNPGTLAPPFTSYPQTTTVTPPGSMDSWTSYQTP------YELTPQFSLLS 425
            .||.|     |::|::.....||.|.:..|.    |.:.||.::|..|      ...|..|...|
Mouse   314 PTSIPQAVSDPSSTVHRPQPLPPSTVHQSTI----PSNADSSSAYCLPSTRHGFSSYTDSFVPPS 374

  Fly   426 PAASPYGTYSG------------QYGAYVHESQLFPMRHYEYG-SPTR--MEMGATTGSVAGNGD 475
            ..::|.....|            .:|...|:.|.      :|. ||..  :|...|..:......
Mouse   375 GPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQT------DYALSPLTGGLEPTTTVSASCSQRL 433

  Fly   476 ESVANGGSYQTAELQTAQQQQLADGTLVTVHAHQQQQQQQQQLNGKYLSAEEA 528
            |.:.|..|..|::.........|..::..|..:|..|..|...:  ||..:.|
Mouse   434 EHMKNVDSLPTSQPYCPPTYSTAGYSMDPVTGYQYGQYGQSAFH--YLKPDIA 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	32/46 (70%)
Pax3	NP_001152992.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		3/6 (50%)
		PAX	34..159	CDD:278709	27/145 (19%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	37..93		14/69 (20%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	113..161		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..228		16/65 (25%)
		Homeobox	222..275	CDD:278475	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		13/45 (29%)
		Pax7	347..391	CDD:289156	9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910