DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and ARX

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_620689.1	Gene:	ARX / 170302	HGNCID:	18060	Length:	562	Species:	Homo sapiens

Alignment Length:	401	Identity:	117/401 - (29%)
Similarity:	154/401 - (38%)	Gaps:	130/401 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PVMINGGSAGGKLKKPDEMCSQLEAGGAGVTPPSSSSTVVNGTTN-------------------- 256
            |.:...|..|| :..|:|...  .|||.|..|.:...|   ||.:
Human   187 PALDELGGPGG-VTHPEERLG--VAGGPGSAPAAGGGT---GTEDDEEELLEDEEDEDEEEELLE 245

  Fly   257 ------------------------GTGNANSSSSAGVGIQGAAGTAGGVAAP----------AAK 287
                                    .||...::::|      |..|.||..:|          |..
Human   246 DDEEELLEDDARALLKEPRRCPVAATGAVAAAAAA------AVATEGGELSPKEELLLHPEDAEG 304

  Fly   288 KDGSS----SKKKGDPNGIKKKKT---RTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSE 345
            |||..    |.......|:.|:|.   |||||:||||||||||::..|||||.|||||::|:|:|
Human   305 KDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTE 369

  Fly   346 SRVQVWFQNRRAKWRKHEPPRKTGYIKTSTPPTATLNPGTLAP--PFTSYPQTTTVTP--PGSMD 406
            :|||||||||||||||.|   |.|   ..|.|.....||.|:.  |.:.|...:...|  |....
Human   370 ARVQVWFQNRRAKWRKRE---KAG---AQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDS 428

  Fly   407 SWT-----------SYQTPYELTPQFSLLSPAASPYGTYSGQYGAYVHESQLFPMRHYEYGSPTR 460
            :||           |...|    |..:.|.|:.:|.| .|...||.|       .||..:.||..
Human   429 AWTAAAAAAAAAFPSLPPP----PGSASLPPSGAPLG-LSTFLGAAV-------FRHPAFISPAF 481

  Fly   461 MEMGAT-----------------TGSVAGNGDESVANGGSYQTAELQTAQQQQLADGTLVTVHAH 508
            ..:.:|                 |.:|.|    :||:|.   .|:..||...:.|..........
Human   482 GRLFSTMAPLTSASTAAALLRQPTPAVEG----AVASGA---LADPATAAADRRASSIAALRLKA 539

  Fly   509 QQQQQQQQQLN 519
            ::...|..|||
Human   540 KEHAAQLTQLN 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	35/46 (76%)
ARX	NP_620689.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..81
		GCG-encoded polyalanine repeat	102..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..255		14/73 (19%)
		Homeobox	332..385	CDD:395001	41/52 (79%)
		OAR	526..544	CDD:397759	1/17 (6%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	530..543		0/12 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.970