DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment repo and Alx4

DIOPT Version :9

Sequence 1:	NP_477026.1	Gene:	repo / 47285	FlyBaseID:	FBgn0011701	Length:	612	Species:	Drosophila melanogaster
Sequence 2:	NP_031468.1	Gene:	Alx4 / 11695	MGIID:	108359	Length:	399	Species:	Mus musculus

Alignment Length:	345	Identity:	105/345 - (30%)
Similarity:	150/345 - (43%)	Gaps:	74/345 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LNGKLDYSSSPK---DQYEPQ----QLQHLYGGSPHHLDHLDHGS-----DGLLQDSSPVMINGG 218
            |...|:.||..:   ::::||    |........|.|| :|..|:     ||.|:      :..|
Mouse    73 LAAPLESSSGARGSFNKFQPQPPTPQPPPAPPAPPAHL-YLQRGACKTPPDGSLK------LQEG 130

  Fly   219 SAG--GKLKKPDEMCSQLEAG-GAGVTPPSSSSTVVNGTTNGTGNANSSSSAGVGIQGAAG---- 276
            |.|  ..|:.|   |...|:. |....||.|..         .|..||..|  |...||.|
Mouse   131 SGGHNAALQVP---CYAKESNLGEPELPPDSEP---------VGMDNSYLS--VKETGAKGPQDR 181

  Fly   277 TAGGVAAPAAKKDGSSSKKKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKL 341
            .:..:.:|..|.|..|:|.       ||::.|||||:|||||||:.|::..||||:|||:||::.
Mouse   182 ASAEIPSPLEKTDSESNKG-------KKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRT 239

  Fly   342 NLSESRVQVWFQNRRAKWRKHEPPRKTGYIKTSTPPTATLNPGTLAPPFTSYPQTTTVTPPGSMD 406
            :|:|:|||||||||||||||.|...:...::|.......|...|.|..:......:.:...|:..
Mouse   240 DLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAAS 304

  Fly   407 SWTSYQTPYELTPQFSLLSPAASPYG------------TYSGQYGAYVHESQLF-------PMRH 452
            ...:...|.:..|  :.:||.|.|.|            :.:|.:....|...||       .:..
Mouse   305 PVPACVVPCDPVP--ACMSPHAHPPGSGASSVSDFLSVSGAGSHVGQTHMGSLFGAAGISPGLNG 367

  Fly   453 YEY-GSPTRMEMGATTGSVA 471
            ||. |.|.|     .|.|:|
Mouse   368 YEMNGEPDR-----KTSSIA 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeobox	313..360	CDD:278475	31/46 (67%)
Alx4	NP_031468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..133		17/66 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..206		10/41 (24%)
		Homeobox	206..258	CDD:278475	36/51 (71%)
		OAR	375..392	CDD:281777	4/13 (31%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	379..392		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970