DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment repo and LDB3

DIOPT Version :9

Sequence 1:NP_477026.1 Gene:repo / 47285 FlyBaseID:FBgn0011701 Length:612 Species:Drosophila melanogaster
Sequence 2:NP_001165081.1 Gene:LDB3 / 11155 HGNCID:15710 Length:732 Species:Homo sapiens


Alignment Length:278 Identity:59/278 - (21%)
Similarity:93/278 - (33%) Gaps:95/278 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 IKTSTPPTATLNPGTLAPP---------------FTSYPQTTTVTPP-GSMDSWTSYQTPYELTP 419
            :..|..|.|..:|||...|               |:|..:.:...|| .|:.:.||.:...:   
Human   118 VAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASDPGPPRASLRAKTSPEGARD--- 179

  Fly   420 QFSLLSPAASPYGTYSGQY----GAYVHE-----SQLFPMRHYEYGSPTRMEMGATTGSVAGNGD 475
               ||.|.|.|..:...||    |.|..|     :|::.|              :..|..:|.| 
Human   180 ---LLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQM--------------SLRGKASGVG- 226

  Fly   476 ESVANGGSYQTAELQTAQQQQLADGTLVTVHAHQQQQQQQQQLNGKYLSAEEAKYVHLQCHQSGG 540
              :..|..||    :......|.|..|.|     .:..:.:.|.||      |..:|.|.:    
Human   227 --LPGGADYQ----ERFNPSALKDSALST-----HKPIEVKGLGGK------ATIIHAQYN---- 270

  Fly   541 GLELSPGASCHLVEAQGQHYVTTATGGAASAGGTS----------SDDNDSGGMQTVIKS----- 590
                :|      :....|..:..|..|.|.|.|:.          :.|:.|...|.||||     
Human   271 ----TP------ISMYSQDAIMDAIAGQAQAQGSDFSGSLPIKDLAVDSASPVYQAVIKSQNKPE 325

  Fly   591 ---EEVSQQQQQQQGQSY 605
               :|.:::....|.:|:
Human   326 DEADEWARRSSNLQSRSF 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
repoNP_477026.1 Homeobox 313..360 CDD:278475
LDB3NP_001165081.1 PDZ_signaling 5..81 CDD:238492
DUF4045 <77..180 CDD:330572 14/67 (21%)
ZM 189..214 CDD:128974 6/24 (25%)
DUF4749 263..353 CDD:318205 19/95 (20%)
Atrophin-1 <387..554 CDD:331285
LIM1_ZASP_Cypher 556..607 CDD:188838
LIM2_Enigma_like 615..666 CDD:188748
LIM3_Enigma_like 674..727 CDD:188749
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6207
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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