Protein Alignment repo and DUX4

DIOPT Version :10

• Sequence 1: NP_477026.1
• Gene: repo / 47285
• FlyBaseID: FBgn0011701
• Length: 612
• Species: Drosophila melanogaster
• Sequence 2: NP_001280727.1
• Gene: DUX4 / 100288687
• HGNCID: 50800
• Length: 424
• Species: Homo sapiens
• Alignment Length: 175
• Identity: 54/175 - (30%)
• Similarity: 77/175 - (44%)
• Gaps: 35/175 - (20%)

  Fly   295 KKGDPNGIKKKKTRTTFTAYQLEELERAFERAPYPDVFAREELAIKLNLSESRVQVWFQNRRAKW 359
            ::|.|.|.:|   ||..|..|...|.||||:..:|.:.||||||.:..|.|||:|:|||||||
Human    88 RRGPPEGRRK---RTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRA-- 147

  Fly   360 RKH-----EPPRKTGYIKTSTPPTATLNPGTLAPPFTSYPQTTTVTPPGSMDSW-TSYQTPYELT 418
             :|     ..|.:.|.:.::.|     ..|..||.:.::..|         .:| |....|:  .
Human   148 -RHPGQGGRAPAQAGGLCSAAP-----GGGHPAPSWVAFAHT---------GAWGTGLPAPH--V 195

  Fly   419 PQFSLLSPAASPYGTYSGQ---YGAYVHESQLFPMRHYEYGSPTR 460
            |    .:|.|.|.|.:..|   ....:..||..|.......:|.|
Human   196 P----CAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPAR 236

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
repo	NP_477026.1	Homeodomain	313..361	CDD:459649	25/47 (53%)
DUX4	NP_001280727.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		homeodomain	25..78	CDD:238039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..102		6/16 (38%)
		Homeodomain	95..149	CDD:459649	29/59 (49%)
		PRK07764	<141..319	CDD:236090	29/119 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..362		5/19 (26%)
		Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377	327..424
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..414
		Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456	405..424