DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)05822 and CAP

DIOPT Version :9

Sequence 1:	NP_001262702.1	Gene:	l(3)05822 / 47260	FlyBaseID:	FBgn0010877	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001369075.1	Gene:	CAP / 36084	FlyBaseID:	FBgn0033504	Length:	2568	Species:	Drosophila melanogaster

Alignment Length:	800	Identity:	154/800 - (19%)
Similarity:	237/800 - (29%)	Gaps:	311/800 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSRPAPAPPGS--RGQSAAAGANASLEQLRLQLQ-----------------QQHLQQQQ------ 43
            |.....|||..  .||     |.|:|.||...|:                 ::|.:|::
  Fly  1735 PESDVEAPPVRILEGQ-----AEANLRQLPRHLREFAKFSTSEQLPDGAQMERHEEQERREEATD 1794

  Fly    44 -GAGGGLQKLTI-------KLPPPPKGPLQSQHKRTTVSNNNNGSLFDE------------PTGG 88
             ......:|.:|       :|||..:|....|     .|..|.|.|:.|            |...
  Fly  1795 NAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQ-----FSGGNRGRLYRERSQTARLVSHNIPLEL 1854

  Fly    89 TSITRKFPQARYTPATNWDDDPFGGGSNGNDRFKKMPPPRPPPPKVLVNGQNMTKSNSSMASAVT 153
            ||.....|.:.:.|.......|.....:......:.|.|.||||...:|      .:||.|..:.
  Fly  1855 TSNHSSSPDSDFNPGCGSSPAPGSSTQSSIPSLVQSPTPAPPPPIEPLN------PSSSTAGGIL 1913

  Fly   154 G-----------GTGRLMSNIFHRKKSTSTASAAASKAAAE--NRVYGLSSGNAGATPSNNSSSS 205
            |           ...:.:..:.|...|.....:...:..|:  .|.|.      |..|..|....
  Fly  1914 GTALLLGLSLLTAWNKFIYKVKHEYMSEPETGSDRPRKMAQLGRRQYD------GIGPVTNDGMP 1972

  Fly   206 ASSAAFSNVDWNAAWNTATTTTTTTSSSSHSSHYASQQTADAQLISFDSPPSSPTFTQKSNSDCV 270
            ....:.........|......|.         |  .|:..|..:|.:..|.:.|::
  Fly  1973 IILRSEVKEPHQHEWYKRLYQTI---------H--KQKNGDDFVIRYKCPRARPSY--------- 2017

  Fly   271 SVDSFSSDSNFSSPNNGSVSQPESGFEDDYHRSRPSTQSPLDPWEAVDSVGLGGVDSFGSAPVRQ 335
                         .:||.||:||..::.||...|..||:|    ..|.||.             .
  Fly  2018 -------------KSNGYVSEPEPNYDSDYSTVRYRTQNP----HRVQSVS-------------S 2052

  Fly   336 TYQVQSRGSDNPLCNGKSLLPPTQSLTMPTIIK--------------------PKISQKPK---- 376
            ...|::...|..|..           |||..||                    ..:|:|.|
  Fly  2053 AVNVRNLNQDEKLYG-----------TMPNPIKSAQNSYKNQPGRIENYTTGHSSVSEKEKKEWW 2106

  Fly   377 -------------APKPPPFIGGHLPPGYSIPSGY------------------------------ 398
                         :...|.:..|:|....:..|||
  Fly  2107 DEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKEVPVSSPLSPVEQKQAYKS 2171

  Fly   399 --AGSETP------PSPPMPK-----GPPPPPPPASSGGISL-----LDVING------------ 433
              ||.|.|      |:|..|:     .||.||.|...|..|.     .|.::|
  Fly  2172 LQAGGEPPLLGFRKPAPEKPRDLDPNAPPIPPQPPVKGLSSYDFPYSTDTVDGSDVNIHFKTPIR 2236

  Fly   434 -------KVDALALSNG-----------CQGYMEE----------------EVVPYAV------- 457
                   ..:.||:...           .:.|::|                :..|.|:
  Fly  2237 HEQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNSRRHTDNFTPSQKSPIALNRYDDFP 2301

  Fly   458 ----------------ALYDFDGIEPGDLSFREGEKIYLLDHPTPEWLRGRTRSGCEGIFPINYV 506
                            ||::|.|....:||||:|:.||:.......|..|. .:...|:.|.:||
  Fly  2302 TDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRRQIDANWYEGE-HNAMIGLLPASYV 2365

  Fly   507 DIKVPLGATGGAAAAPTASAAAPSPSPSQQQLPTALCLYHFPGEVEGDLALQENELVTVLYRINE 571
            :|            .....|..||..||:.|   |...|:|..:...:|:|.:.||||:..|::.
  Fly  2366 EI------------VSRDGARTPSKRPSEGQ---ARAKYNFQAQSGIELSLNKGELVTLTRRVDG 2415

  Fly   572 DWLYGEVAGRQGQFPANFLD 591
            :|..|::|.|:|.||.::::
  Fly  2416 NWFEGKIANRKGIFPCSYVE 2435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)05822	NP_001262702.1	SH3	452..506	CDD:214620	17/76 (22%)
l(3)05822	NP_001262702.1	SH3	540..591	CDD:302595	17/50 (34%)
CAP	NP_001369075.1	MDN1	<43..328	CDD:227596
		Sorb	1959..2003	CDD:413404	8/60 (13%)
		SH3_Sorbs_1	2315..2367	CDD:212715	17/52 (33%)
		SH3_Sorbs_2	2384..2436	CDD:212716	18/54 (33%)
		SH3_Sorbs_3	2514..2567	CDD:212714
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46655
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.000