DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmGlut and slc17a8

DIOPT Version :9

Sequence 1:	NP_620115.2	Gene:	dmGlut / 47253	FlyBaseID:	FBgn0010497	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001076304.1	Gene:	slc17a8 / 563467	ZFINID:	ZDB-GENE-060503-416	Length:	590	Species:	Danio rerio

Alignment Length:	509	Identity:	161/509 - (31%)
Similarity:	258/509 - (50%)	Gaps:	48/509 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FVIPQRVILAIMGFLAILNAYTMRVCLSQAITVLVVKKNSTDDDSEAICEPDDIDEGTSVGGDFE 79
            |.:|:|.|:|::..|....::.:|..|..|| |.:|..|:...:..|:.:|          ..|.
Zfish    70 FGLPKRYIIAMLSGLGFCISFGIRCNLGVAI-VEMVNNNTVYINGTAVMQP----------AQFN 123

  Fly    80 WSEELQGLILSSFYIGYIVTHIPGGLLAEKFGGKWTLGLGILSTAVFTMLTPLA--INKGDSDWL 142
            |..|..|||..||:.|||||.||||.::.|.......|..|..|:|..|..|.|  ::.|   .:
Zfish   124 WDPETVGLIHGSFFWGYIVTQIPGGFISNKLAANRVFGAAIFLTSVLNMFIPSAARVHYG---CV 185

  Fly   143 IVTRVLMGLGEGTTFPALSVLLAAWVPANERGKLGALVLGGGQVGTIMGNLLSGVFIDAYGWEFV 207
            :..|:|.||.||.|:||...:.:.|.|..||.:|......|...|.::...|:|:.:...||..|
Zfish   186 MFVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYVGWPSV 250

  Fly   208 FYFFGGLGVVWFAIFMFLCYSDPTSHPFIKPSEREYLVKEIG----TISRNEDLPPTPWKAILTN 268
            ||.:|..|::|:..::.|.|:.|..||.|...||.|:...||    .:|..|.. .|||:...|:
Zfish   251 FYIYGVFGIIWYIFWILLAYNSPAVHPTISEEERNYIETSIGEGANLMSSTEKF-KTPWREFFTS 314

  Fly   269 LPMFALVAAQIGHDWGFYIMVTDLPKYMADVLQFSIKANGLYSSLPYVMMWIVSVGSGFVADWMI 333
            :|::|::.|.....|.||:::...|.|..:|..|.|...|:.|::|:::|.|:....|.:||::.
Zfish   315 MPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFPISKVGILSAVPHMVMTIIVPIGGQLADFLR 379

  Fly   334 RRGVLSTTNTRKVMT--GLAAFGPAIFMVGASYAGCDRVLVVVLFTICMGLMGAYYAGMKLSPLD 396
            .|.:||||..||:|.  |.......:.:||.|:.   |.:.:....:.:|..|...:|..::.||
Zfish   380 SRKILSTTTVRKIMNCGGFGMEATLLLVVGFSHT---RAVAISFLILAVGFSGFAISGFNVNHLD 441

  Fly   397 MSPNYAGTLMAITNGIGAITGVITPYLVGVMTPNASLLEWRLVFWVAFGVLCFTAVI-YCIWASG 460
            ::|.||..||.|:||:|.::|::.|.:||.:|.:.:.|||:.||.:| .::.:|.|| |.|:|||
Zfish   442 IAPRYASILMGISNGVGTLSGMVCPLIVGALTKHKTRLEWQHVFVIA-SMVHYTGVIFYAIFASG 505

  Fly   461 EVQ----PFNNA--------------PIQPRSVDFEAQERKVGG--EKTSGLEQ 494
            |.|    |.|.:              ..:|.|....|..:|..|  :.:||.:|
Zfish   506 EKQDWADPENTSDEKCGIIGEDELADETEPSSDSGLATRQKTYGTTDNSSGRKQ 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmGlut	NP_620115.2	2A0114euk	25..463	CDD:129972	145/446 (33%)
dmGlut	NP_620115.2	MFS	77..458	CDD:119392	131/389 (34%)
slc17a8	NP_001076304.1	2A0114euk	75..514	CDD:129972	149/457 (33%)
		MFS	81..503	CDD:119392	141/440 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..590		8/34 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1866
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.770