DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmGlut and Slc17a8

DIOPT Version :9

Sequence 1:	NP_620115.2	Gene:	dmGlut / 47253	FlyBaseID:	FBgn0010497	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	456	Identity:	150/456 - (32%)
Similarity:	231/456 - (50%)	Gaps:	29/456 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IPQRVILAIMGFLAILNAYTMRVCLSQAITVLVVKKNST---DDDSEAICEPDDIDEGTSVGGDF 78
            ||:|.|:|:|..|....::.:|..|..||..:|  .|||   |...|.            ....|
  Rat    72 IPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMV--NNSTVYVDGKPEI------------QTAQF 122

  Fly    79 EWSEELQGLILSSFYIGYIVTHIPGGLLAEKFGGKWTLGLGILSTAVFTMLTPLA--INKGDSDW 141
            .|..|..|||..||:.|||||.||||.::.||......|..|..|:...|..|.|  ::.|   .
  Rat   123 NWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG---C 184

  Fly   142 LIVTRVLMGLGEGTTFPALSVLLAAWVPANERGKLGALVLGGGQVGTIMGNLLSGVFIDAYGWEF 206
            ::..|:|.||.||.|:||...:.:.|.|..||.:|......|...|.::...|:||.:...||..
  Rat   185 VMCVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWAS 249

  Fly   207 VFYFFGGLGVVWFAIFMFLCYSDPTSHPFIKPSEREYLVKEIGTISRNEDLPP--TPWKAILTNL 269
            |||.:|..|::|:..::...|..|..||.|...||.|:...||..:....|..  |||:...|:|
  Rat   250 VFYIYGMFGIIWYMFWLLQAYECPAVHPTISNEERTYIETSIGEGANLASLSKFNTPWRRFFTSL 314

  Fly   270 PMFALVAAQIGHDWGFYIMVTDLPKYMADVLQFSIKANGLYSSLPYVMMWIVSVGSGFVADWMIR 334
            |::|::.|.....|.||:::...|.|..:|..|:|...||.|::|:::|.||....|.:||::..
  Rat   315 PVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRS 379

  Fly   335 RGVLSTTNTRKVMT--GLAAFGPAIFMVGASYAGCDRVLVVVLFTICMGLMGAYYAGMKLSPLDM 397
            |.:|:||..||:|.  |.......:.:||.|:.   :.:.:....:.:|..|...:|..::.||:
  Rat   380 RKILTTTAVRKIMNCGGFGMEATLLLVVGFSHT---KGVAISFLVLAVGFSGFAISGFNVNHLDI 441

  Fly   398 SPNYAGTLMAITNGIGAITGVITPYLVGVMTPNASLLEWRLVFWVAFGVLCFTAVIYCIWASGEV 462
            :|.||..||.|:||:|.::|::.|.:||.||.:.:..||:.||.:|..|.....:.|.::||||.
  Rat   442 APRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGVIFYGVFASGEK 506

  Fly   463 Q 463
            |
  Rat   507 Q 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmGlut	NP_620115.2	2A0114euk	25..463	CDD:129972	144/446 (32%)
dmGlut	NP_620115.2	MFS	77..458	CDD:119392	128/386 (33%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	141/442 (32%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342512
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740