DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmGlut and SLC17A5

DIOPT Version :9

Sequence 1:	NP_620115.2	Gene:	dmGlut / 47253	FlyBaseID:	FBgn0010497	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	426	Identity:	169/426 - (39%)
Similarity:	247/426 - (57%)	Gaps:	16/426 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RVILAIMGFLAILNAYTMRVCLSQAITVLVVKKNSTDDD---SEAICE---PDDIDEGTSVGGDF 78
            |..|||:.|......|.:||.||.|: |.:|..|:|.:|   |:|..|   |..:.. ...|..:
Human    39 RYNLAILAFFGFFIVYALRVNLSVAL-VDMVDSNTTLEDNRTSKACPEHSAPIKVHH-NQTGKKY 101

  Fly    79 EWSEELQGLILSSFYIGYIVTHIPGGLLAEKFGGKWTLGLGILSTAVFTMLTPLAINKGDSDWLI 143
            :|..|.||.||.||:.|||:|.||||.:|.|.|||..||.|||.|||.|:.||:|.:.|... ||
Human   102 QWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGP-LI 165

  Fly   144 VTRVLMGLGEGTTFPALSVLLAAWVPANERGKLGALVLGGGQVGTIMGNLLSGVFIDAYGWEFVF 208
            |.|.|.|||||.||||:..:.::|.|..||.||.::...|.|:||::...|||:......|.:||
Human   166 VLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVF 230

  Fly   209 YFFGGLGVVWFAIFMFLCYSDPTSHPFIKPSEREYLVKEIGTISRNE--DLPPTPWKAILTNLPM 271
            ||||.:|:.||.::::|....|..|..|...|:||::..:    ||:  .....||..||.:||:
Human   231 YFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSL----RNQLSSQKSVPWVPILKSLPL 291

  Fly   272 FALVAAQIGHDWGFYIMVTDLPKYMADVLQFSIKANGLYSSLPYVMMWIVSVGSGFVADWMIRRG 336
            :|:|.|...::|.||.::|.||.||.::|:|:::.||..|||||:..|:..:.||..||.:..:.
Human   292 WAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKW 356

  Fly   337 VLSTTNTRKVMTGLAAFGPAIFMVGASYAGCDRVLVVVLFTICMGLMGAYYAGMKLSPLDMSPNY 401
            ..||...|::.:.:...|||:|:|.|.:.|||..|.|...||...|.|...:|..::.||::|:|
Human   357 NFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSY 421

  Fly   402 AGTLMAITNGIGAITGVITPYLVGVMTPNASLLEWR 437
            ||.|:.|||....|.|::.|.:...:||:|. ::||
Human   422 AGILLGITNTFATIPGMVGPVIAKSLTPDAG-VQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmGlut	NP_620115.2	2A0114euk	25..463	CDD:129972	166/421 (39%)
dmGlut	NP_620115.2	MFS	77..458	CDD:119392	148/363 (41%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	168/423 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148599
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840