DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dmGlut and Slc17a5

DIOPT Version :9

Sequence 1:	NP_620115.2	Gene:	dmGlut / 47253	FlyBaseID:	FBgn0010497	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_766361.1	Gene:	Slc17a5 / 235504	MGIID:	1924105	Length:	495	Species:	Mus musculus

Alignment Length:	449	Identity:	174/449 - (38%)
Similarity:	262/449 - (58%)	Gaps:	9/449 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 RVILAIMGFLAILNAYTMRVCLSQAITVLVVKKNSTDDDSEAICEPDDIDEGTSV-----GGDFE 79
            |..|||:.|......|.:||.||.|: |.:|..|:|..|:....|..:......|     |..::
Mouse    39 RYNLAILAFCGFFVLYALRVNLSVAL-VDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYK 102

  Fly    80 WSEELQGLILSSFYIGYIVTHIPGGLLAEKFGGKWTLGLGILSTAVFTMLTPLAINKGDSDWLIV 144
            |..|.||.||.||:.|||||.||||.:|.:.|||..||||||.|:|||:.||||.:.|... |:|
Mouse   103 WDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVT-LVV 166

  Fly   145 TRVLMGLGEGTTFPALSVLLAAWVPANERGKLGALVLGGGQVGTIMGNLLSGVFIDAYGWEFVFY 209
            .|.|.|||||.||||:..:.::|.|..||.||..:...|.|:||::...|||:......|.:|||
Mouse   167 LRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFY 231

  Fly   210 FFGGLGVVWFAIFMFLCYSDPTSHPFIKPSEREYLVKEIGTISRNEDLPPTPWKAILTNLPMFAL 274
            .||.:|:|||.::|::....|.:|..|...|:||:|..:.....::.:  .||.:||.:||::|:
Mouse   232 LFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSSQKV--VPWGSILKSLPLWAI 294

  Fly   275 VAAQIGHDWGFYIMVTDLPKYMADVLQFSIKANGLYSSLPYVMMWIVSVGSGFVADWMIRRGVLS 339
            |.|...::|.||.::|.||.||.::|:|:::.||..|:|||...|:..:..|..||::..:...|
Mouse   295 VVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFS 359

  Fly   340 TTNTRKVMTGLAAFGPAIFMVGASYAGCDRVLVVVLFTICMGLMGAYYAGMKLSPLDMSPNYAGT 404
            |.:.|::.:.:...|||:|:|.|.:.|||..|.|...||...|.|...:|..::.||::|:|||.
Mouse   360 TISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGI 424

  Fly   405 LMAITNGIGAITGVITPYLVGVMTPNASLLEWRLVFWVAFGVLCFTAVIYCIWASGEVQ 463
            |:.|||....|.|:..|.:...:||:.::.||:.||.:|..:..|.|:.:.::|.||||
Mouse   425 LLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQ 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dmGlut	NP_620115.2	2A0114euk	25..463	CDD:129972	169/442 (38%)
dmGlut	NP_620115.2	MFS	77..458	CDD:119392	150/380 (39%)
Slc17a5	NP_766361.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Dileucine internalization motif. /evidence=ECO:0000250	22..23
		2A0114euk	30..491	CDD:129972	174/449 (39%)
		MFS	99..478	CDD:119392	150/381 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840