DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SrpRalpha and srpra

DIOPT Version :9

Sequence 1:	NP_524887.2	Gene:	SrpRalpha / 47251	FlyBaseID:	FBgn0010391	Length:	614	Species:	Drosophila melanogaster
Sequence 2:	XP_002940432.3	Gene:	srpra / 100271764	XenbaseID:	XB-GENE-1013778	Length:	649	Species:	Xenopus tropicalis

Alignment Length:	660	Identity:	346/660 - (52%)
Similarity:	443/660 - (67%)	Gaps:	58/660 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLDFVVIFTKGGVVLWHSNASGNSFASCINSLIRGVILEERNTEAKYYEEDHLAVQFKLDNELDL 65
            ||||..||:|||:|||.......||...:|:|||.|||:||... .||..|.|.:::||||:.:|
Frog     1 MLDFFTIFSKGGIVLWCFQGVPASFTGPVNALIRSVILQERGGN-NYYNHDSLTLKYKLDNQFEL 64

  Fly    66 VYAAIFQKVIKLNYLDGFLADMQAAFKEKY-------GDI-RLGDDYDFDREYRRVLSAAEEASA 122
            |:...:||::.|.|:|..:.|:...|::||       |.: .|...::|..::..:|.||||:|
Frog    65 VFVVGYQKILTLTYVDKLIDDVHKVFRDKYRNQIQHNGTLGLLNGSFEFQDDFNTILRAAEESS- 128

  Fly   123 KQVKAPKTMRSYNESQKSKKTVASMIQDDKKPVEK--------RVNIQEAPP----------PSK 169
             :.:||..|:.:.:|.||:|||.|||:   ||.:|        :.:.:|:|.          .|.
Frog   129 -KARAPPAMKRFEQSLKSQKTVKSMIE---KPGDKVKENNKKNKASKKESPASEVVTSSNKLSSA 189

  Fly   170 SQPSSPPTGSPMDKIIMEK--RRKLREKLTPTKKTSPSDSKSSKPE---KAGKKPRVWDLG-GNS 228
            .:.|||......|::..|:  .||..|......|.....:||.|||   :.||:||||..| .|:
Frog   190 PKQSSPAAAGDKDELTAEEIMLRKREEFFRKQMKGGNKVNKSPKPEAQKEKGKQPRVWVPGASNN 254

  Fly   229 KDAALLDRSRDSP----------DDVQYQNINSELVGTMQGVIRDLDVESEDEADNED----ASS 279
            |:   ||.|:.:|          ||:.....:||   :|||...||:.:|..|.:.|:    .:.
Frog   255 KE---LDYSKAAPKGSSEVPIPIDDLATLQYSSE---SMQGNPPDLECDSSSEEEEEELPTIKAK 313

  Fly   280 EGEAEEQVQSKKGKRGGLLSYFKGIVGAKTMSLADLQPALEKMRDHLISKNVASEIAAKLCDSVA 344
            ...|..:..|||...||:....||:||||::::.|::|.||||:||||:||||::||.:||:|||
Frog   314 AAPAATKSSSKKSSFGGMFGMLKGLVGAKSLTMEDMEPVLEKMKDHLIAKNVAADIAVQLCESVA 378

  Fly   345 ASLDGKQMGTFDSIASQVKEALTESLVRILSPKRRIDIIRDALESKRNGRPYTIIFCGVNGVGKS 409
            ..|:||.||||:::.|.||:||.||||:||.||||:||:||.:|::...|||.|.||||||||||
Frog   379 KKLEGKVMGTFETVTSSVKQALQESLVQILQPKRRVDILRDVMEAQHLRRPYVITFCGVNGVGKS 443

  Fly   410 TNLAKICFWLIENDFNVLIAACDTFRAGAVEQLRTHTRHLNALHPAAKHDGRNMVQLYEKGYGKD 474
            ||||||.||||||.|:|||||||||||||||||||||:.||:.||..||.|..||||||||||||
Frog   444 TNLAKISFWLIENGFSVLIAACDTFRAGAVEQLRTHTQRLNSRHPPEKHKGCTMVQLYEKGYGKD 508

  Fly   475 AAGIAMEAIKFAHDTRVDVVLVDTAGRMQDNEPLMRSLSKLIKVNNPDLVLFVGEALVGNEAVDQ 539
            |||||||||.:|.:...||||||||||||||.|||.:|:|||.||.|||||||||||||||||||
Frog   509 AAGIAMEAISYARNQAFDVVLVDTAGRMQDNAPLMTALAKLIAVNVPDLVLFVGEALVGNEAVDQ 573

  Fly   540 LVKFNQSLADYSSNENPHIIDGIVLTKFDTIDDKVGAAISMTYITGQPIVFVGTGQTYADLKAIN 604
            |||||::|||||..:.|.:|||||||||||||||||||||||||||||||||||||||.||:.:|
Frog   574 LVKFNKALADYSMADKPRLIDGIVLTKFDTIDDKVGAAISMTYITGQPIVFVGTGQTYCDLRLLN 638

  Fly   605 VNAVVNSLMK 614
            ..|||.:|||
Frog   639 AKAVVAALMK 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SrpRalpha	NP_524887.2	SRP-alpha_N	27..268	CDD:282006	91/282 (32%)
		PRK14974	258..613	CDD:237875	242/358 (68%)
		SRP54_N	299..374	CDD:214941	43/74 (58%)
		SRP	396..592	CDD:239389	160/195 (82%)
srpra	XP_002940432.3	SRP-alpha_N	27..297	CDD:397968	91/281 (32%)
		SRP54_N	328..400	CDD:397149	39/71 (55%)
		SRalpha_C	430..646	CDD:349785	173/215 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	347	1.000	Domainoid score	I1039
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2364
Inparanoid	1	1.050	607	1.000	Inparanoid score	I919
OMA	1	1.010	-	-		QHG53679
OrthoDB	1	1.010	-	-		D364694at33208
OrthoFinder	1	1.000	-	-		FOG0005144
OrthoInspector	1	1.000	-	-		oto102205
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3103
SonicParanoid	1	1.000	-	-		X2595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010