DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment woc and ZMYM3

DIOPT Version :9

Sequence 1:	NP_001097946.1	Gene:	woc / 47249	FlyBaseID:	FBgn0010328	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_005087.1	Gene:	ZMYM3 / 9203	HGNCID:	13054	Length:	1370	Species:	Homo sapiens

Alignment Length:	1753	Identity:	443/1753 - (25%)
Similarity:	666/1753 - (37%)	Gaps:	550/1753 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 DPVDAEEPAEEPTPNEEPQGGEDEQPQTEAVRVDPQEEPEEAEEETDALQATAEEVEAAAAEA-D 160
            ||.|...|.:..|..|:|..|:        :.||.:...:..|.:|...:..|....:.::.| |
Human     2 DPSDFPSPFDPLTLPEKPLAGD--------LPVDMEFGEDLLESQTAPTRGWAPPGPSPSSGALD 58

  Fly   161 AVDGGPASPEAMDVDEGEVDAEGEAEQEAEDDAALDREATDDVDMQSVGADSHQA----EDAEPP 221
            .:|    :|..::.|.|.:|...|                    :..:|...::|    |....|
Human    59 LLD----TPAGLEKDPGVLDGATE--------------------LLGLGGLLYKAPSPPEVDHGP 99

  Fly   222 EGR---DEVDTSLEEQENGQDPDEREKDAAADEDDPDAEGDAESEQVDENAEETGEAEHGDDTVE 283
            ||.   |..|.:||....||.|:....|..|..:....||
Human   100 EGTLAWDAGDQTLEPGPGGQTPEVVPPDPGAGANSCSPEG------------------------- 139

  Fly   284 NVLEPEESDVCLIPDD----QETEVTEAE-KELARENAEKAAEEEEAEERQAKTPDNDRKSPADA 343
             :|||      |.||.    |...:.|.| ..:|........:|||..:.|.::|:
Human   140 -LLEP------LAPDSPITLQSPHIEEEETTSIATARRGSPGQEEELPQGQPQSPN--------- 188

  Fly   344 AADPEDDSAAAVDATDVSPTTPTDAQAGAKSAATGIAEADGVAAAANEEEAGGDVPDPDEPTAEE 408
                             :|.:|:            :.|..|....:::.:.||..| |..|:.
Human   189 -----------------APPSPS------------VGETLGDGINSSQTKPGGSSP-PAHPSL-- 221

  Fly   409 SSSAGAGEPGSTPKIIISWIVGSVQKCKQCGDEKNCGFRYR--SPEESEEMDKEKENDKAEENAE 471
                    ||.          |...|..:...|:....|.|  .|.:.|.:|..:....::|::
Human   222 --------PGD----------GLTAKASEKPPERKRSERVRRAEPPKPEVVDSTESIPVSDEDS- 267

  Fly   472 EGEEEEARQKPAAPSGFEYICDTACVDALLEDQPGKYFVRRKKFLVEEVVREEGAAEAEASADGE 536
                                      ||:::|.
Human   268 --------------------------DAMVDDP-------------------------------- 274

  Fly   537 GGDAEEEATPANTQDCLQCKDKTRCKYFIKQDQDCFYICNDDCFNLLNAEEPDKFKLKRHSIRVR 601
                                                   ||:.|                 :..|
Human   275 ---------------------------------------NDEDF-----------------VPFR 283

  Fly   602 NIGATTLQPPQNSPTKRTDGSVVARTVEEAETARLDRIESFRRRCADCEADINTDEKQLMWETMD 666
                     |:.||......||..|....|...::        .||.|...:...:.
Human   284 ---------PRRSPRMSLRSSVSQRAGRSAVGTKM--------TCAHCRTPLQKGQT-------- 323

  Fly   667 FCNEVCLGSYQRTIGSTCETCKQEVSSIALGKYCVRFGFDVRQFCCAGCLNTFKK---GLKTCSC 728
                    :|||.                        |.. :.||.:.||.||.|   |.|||:.
Human   324 --------AYQRK------------------------GLP-QLFCSSSCLTTFSKKPSGKKTCTF 355

  Fly   729 CQKDISGGQEGFLAPVGDKDQFKDFCSQSCLRRYESMCN---PRRKLRTDV--CGVCNNQKPVRV 788
            |:|:|...::..:|..|....|.:||:..||..||:...   |:.....|.  |.:|.....|..
Human   356 CKKEIWNTKDSVVAQTGSGGSFHEFCTSVCLSLYEAQQQRPIPQSGDPADATRCSICQKTGEVLH 420

  Fly   789 EMLLEDREHYFCSNPCFSAFKFVSNVNADPCAMCSKYFERRSAESYTIYNEQQSP---------- 843
            |:......|..||:.|||.|:....:..:.|..|..|          ||.:..||
Human   421 EVSNGSVVHRLCSDSCFSKFRANKGLKTNCCDQCGAY----------IYTKTGSPGPELLFHEGQ 475

  Fly   844 -KVFCSRVCINVYIIVNRHIVSCQWCKVKKYNFDMIYQIGGPHDQETLTCSINCLTMHGVS---- 903
             |.||:..|:..|...|..:..|.|||....||:|:..: ..:.:.:|.||:.|.|.:.|.
Human   476 QKRFCNTTCLGAYKKKNTRVYPCVWCKTLCKNFEMLSHV-DRNGKTSLFCSLCCTTSYKVKQAGL 539

  Fly   904 ------CNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQ--------------- 947
                  |:...|:::  |.|        :....|.::..||:..|..:||
Human   540 TGPPRPCSFCRRSLS--DPC--------YYNKVDRTVYQFCSPSCWTKFQRTSPEGGIHLSCHYC 594

  Fly   948 -NQFARAPLTLD--------------SDLPPSSAGSSKSQQQSNRGNK---NAAPFPTGLPKRV- 993
             :.|:..|..||              .|.  .......||.:..|..|   ....| :|:.|..
Human   595 HSLFSGKPEVLDWQDQVFQFCCRDCCEDF--KRLRGVVSQCEHCRQEKLLHEKLRF-SGVEKSFC 656

  Fly   994 --------------KLKL--------SHTGKGGVGGKKSGS------------------------ 1012
                          ||.|        |.|.:.||..:..||
Human   657 SEGCVLLYKQDFTKKLGLCCITCTYCSQTCQRGVTEQLDGSTWDFCSEDCKSKYLLWYCKAARCH 721

  Fly  1013 -----GTMLPVI---STVQSLASGETEARIGNLTVRRKRGRPRESGTSSPPLSMPGVHPPAQRGR 1069
                 |.:|..|   ..::...:.:...|..:     ::.:|.....|.|...:....|.::...
Human   722 ACKRQGKLLETIHWRGQIRHFCNQQCLLRFYS-----QQNQPNLDTQSGPESLLNSQSPESKPQT 781

  Fly  1070 PRKHAVDYSARSPSPTMSGGSSHMG-IPVRRNTTTTMDFGPATVTETKIITVPPYPKAV--RNVN 1131
            |.:..|:.|....:|..:|   ::| |||:..:..|....|           ||.|.|.  :|..
Human   782 PSQTKVENSNTVRTPEENG---NLGKIPVKTRSAPTAPTPP-----------PPPPPATPRKNKA 832

  Fly  1132 ISCKPLTVTQGEQCSPDVRDCATQTEKDYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIP 1196
            ..||||...:|..|..:::...:|||:.....:::|:|||||||.||::|....|||..:|:|:|
Human   833 AMCKPLMQNRGVSCKVEMKSKGSQTEEWKPQVIVLPIPVPIFVPVPMHLYCQKVPVPFSMPIPVP 897

  Fly  1197 VPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEKHESDSDSDNEIKPDPGLVA 1261
            ||:|:|||..:...|::.|::::.|:|.:||||::|.||||:||.:....:.||        |..
Human   898 VPMFLPTTLESTDKIVETIEELKVKIPSNPLEADILAMAEMIAEAEELDKASSD--------LCD 954

  Fly  1262 LQYQNSLESVAQQQQQQQVVDVSGAGHNPYGDDMLQIALKMATGDYDNHHQTSTVDLETSMTANT 1326
            |....|.|.:.:.      .|:.|    |..||:|.:|:|||     |.......|||.....|.
Human   955 LVSNQSAEGLLED------CDLFG----PARDDVLAMAVKMA-----NVLDEPGQDLEADFPKNP 1004

  Fly  1327 ISSQSPMGHDGMGQMGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMD 1391
            :.....:  |.:...|:...:......|..:...:|:||  .|:.:..:|:|.|......|
Human  1005 LDINPSV--DFLFDCGLVGPEDVSTEQDLPRTMRKGQKR--LVLSESCSRDSMSSQPSCTG---- 1061

  Fly  1392 HSALQQQSQQAQQPQEKPDAQMFLKYTFGVNAWKQWVMTKNADIEKS---SMRRRP----FKTEL 1449
                                   |.|::||||||.||.:|.|:.|.|   .:|..|    .|.::
Human  1062 -----------------------LNYSYGVNAWKCWVQSKYANGETSKGDELRFGPKPMRIKEDI 1103

  Fly  1450 LQMTADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECL 1514
            |..:|.||||.|..||:|:.:|||..|.||:||||.|||||||..|.|:.|||.|.||..|.:.|
Human  1104 LACSAAELNYGLAQFVREITRPNGERYEPDSIYYLCLGIQQYLLENNRMVNIFTDLYYLTFVQEL 1168

  Fly  1515 DEVARKFSVLYNDSQYIVTRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSF 1579
            ::....:......:..:.:||||||||||||||.:||.|||:||||||||.|.|.|.||||||||
Human  1169 NKSLSTWQPTLLPNNTVFSRVEEEHLWECKQLGVYSPFVLLNTLMFFNTKFFGLQTAEEHMQLSF 1233

  Fly  1580 SHIMKHWKRSSQNSKVP-GSRNVL-LRFYPP---QAGLDANPRKKK------VYEQQENEENPLR 1633
            ::::    |.|:....| |:..|: :|:|.|   :.|.|..|.|:|      :.||:||..||||
Human  1234 TNVV----RQSRKCTTPRGTTKVVSIRYYAPVRQRKGRDTGPGKRKREDEAPILEQRENRMNPLR 1294

  Fly  1634 CPVRLYEFYLSKCPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEI 1696
            |||:.|||||||||||::||||||||||||||:.:||:|||...:.:..|:.||:|:..|:||
Human  1295 CPVKFYEFYLSKCPESLRTRNDVFYLQPERSCIAESPLWYSVIPMDRSMLESMLNRILAVREI 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	TRASH	684..721	CDD:214799	7/36 (19%)
		zf-FCS	724..762	CDD:283998	13/37 (35%)
		DUF3504	1531..1690	CDD:288835	95/169 (56%)
ZMYM3	NP_005087.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..72		18/81 (22%)
		PHA03307	2..>305	CDD:223039	86/549 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	90..301		63/425 (15%)
		TRASH	311..347	CDD:214799	14/76 (18%)
		zf-FCS	348..389	CDD:399461	14/40 (35%)
		zf-FCS	404..440	CDD:399461	11/35 (31%)
		zf-FCS	446..488	CDD:399461	11/51 (22%)
		zf-FCS	493..532	CDD:399461	12/39 (31%)
		zf-FCS	541..578	CDD:399461	8/46 (17%)
		zf-FCS	586..623	CDD:399461	4/36 (11%)
		zf-FCS	628..664	CDD:399461	7/36 (19%)
		zf-FCS	674..710	CDD:399461	7/35 (20%)
		zf-FCS	715..751	CDD:399461	3/35 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..830		18/84 (21%)
		DUF3504	1185..1353	CDD:403286	96/171 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	224	1.000	Domainoid score	I2565
eggNOG	1	0.900	-	-		E1_2CMKN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	547	1.000	Inparanoid score	I1155
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266757at33208
OrthoFinder	1	1.000	-	-		FOG0004219
OrthoInspector	1	1.000	-	-		otm40862
orthoMCL	1	0.900	-	-		OOG6_103093
Panther	1	1.100	-	-	O	PTHR45736
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4937
SonicParanoid	1	1.000	-	-		X789
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860