Protein Alignment woc and ZMYM4

DIOPT Version :10

• Sequence 1: NP_001097946.1
• Gene: woc / 47249
• FlyBaseID: FBgn0010328
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001362582.1
• Gene: ZMYM4 / 9202
• HGNCID: 13055
• Length: 1551
• Species: Homo sapiens
• Alignment Length: 1819
• Identity: 473/1819 - (26%)
• Similarity: 699/1819 - (38%)
• Gaps: 583/1819 - (32%)

  Fly   173 DVDEGEVDAEGEAEQEAEDDAALDREATDDVDMQSVGA--DSHQAEDAEPPEGRDEVDTSLEEQE 235
            :|:.|.....||.||::        .|..|..:::.|.  |:..:||.:     ..:..:|:...
Human     5 EVESGPRKRVGEFEQKS--------GAVFDEIVENCGGIMDTEMSEDID-----HNLTPTLDSMS 56

  Fly   236 NGQDPDEREKDAAADEDD-----------PDAEGDAESEQVDENAEETGEAEHGDDT--VENVLE 287
            .|.......:::..||||           |....|.|.||...:.:....:.|.||:  ||..:.
Human    57 YGMPNQTGSENSLLDEDDYFLNSGDLAGIPVVGSDNEDEQDFSSKDNLVSSIHTDDSLEVERRVT 121

  Fly   288 PEESDVCLIPDDQETEVTEAEKE--------------------LARENAEKAAEEEE-------A 325
            ..|||     ::.|.::....|:                    |.|||:::....:|       .
Human   122 QHESD-----NENEIQIQNKLKKDFPKQFDQVSVFKSIRKDFSLVRENSKETFSGKEKNRDLTYE 181

  Fly   326 EERQAKTPDND-----RKSPADAAADPEDDSAAAVDATDVSPTTPTDAQAGAKSAATGIAEADGV 385
            .|::...|..|     :.|..|.||:..:::.    .|.:..|..|:.:             |..
Human   182 REKRLDKPHKDLDSRLKSSFFDKAANQVEETL----HTHLPQTPETNFR-------------DSS 229

  Fly   386 AAAANEEEAGGDVPD--------PDEPTAEESSSAGAGEPGSTPKIIISWIVGSVQKCKQCGDEK 442
            ...||:|..|.::.:        .:||..:|...|.|.:.|...||               .||
Human   230 YPFANKESIGSELGNSFASNIRIKEEPLDDEYDKAMAPQQGLLDKI---------------KDE- 278

  Fly   443 NCGFRYRSPEESEEMDKEKENDKAEENAEEGEEE-----EARQKPAAP---SGFEYICDTACVDA 499
                    |:.::|....:     ::..:|||.:     .....|.||   :||:....::.::.
Human   279 --------PDNAQEYSHGQ-----QQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASSGMNK 330

  Fly   500 LLEDQPGKYFVRRKKFLVEEVVREEGAAEAEASADGEGGDAEEEATPANTQDCLQCKDKTRCKYF 564
            :|...|                    |.....|..|                         ||..
Human   331 MLPSVP--------------------ATAVRVSCSG-------------------------CKKI 350

  Fly   565 IKQDQDCFYICNDDCFNLLNAEEPDKFKLKRHSIRVRNIGATTLQPPQNSPTKRTDGSVVARTVE 629
            :::.|..:                            :..|:|.|
Human   351 LQKGQTAY----------------------------QRKGSTQL--------------------- 366

  Fly   630 EAETARLDRIESFRRRCADCEADINTDEKQLMWETMDFCNEVCLGSYQRTIGSTCETCKQEVSSI 694
                                                 ||:.:||..|         |........
Human   367 -------------------------------------FCSTLCLTGY---------TVPPARPPP 385

  Fly   695 ALGKYCVRFGFDVRQFCCAGCLNTFKKGLKTCSCCQKDISGGQEGFLAPVGDKDQFKDFCSQSCL 759
            .|.|                         ||||.|.|||...::...|...:....|||||||||
Human   386 PLTK-------------------------KTCSSCSKDILNPKDVISAQFENTTTSKDFCSQSCL 425

  Fly   760 RRYESMCNPRRKLRTD----VCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAFKFVSNVNADPCA 820
            ..||....|...:.|:    .|.:|.....:|.|:..::..|..||:.|||.|:..:|:..:.|.
Human   426 STYELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCE 490

  Fly   821 MCSKYFERRSAESYTIYNEQQSPKVFCSRVCINVYIIVNRHIVSCQWCKVKKYNFDMIYQIGGPH 885
            .|..|....|.:.:.:..|.||.| |||..||..|...:..|..|..||..:.:.:||.......
Human   491 NCGGYCYSGSGQCHMLQIEGQSKK-FCSSSCITAYKQKSAKITPCALCKSLRSSAEMIENTNSLG 554

  Fly   886 DQETLTCSINCLTMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQNQF 950
            ..| |.||:|||:.:.|....||....:|::|.....|||||.|||.|:||||:|.||:.|||.|
Human   555 KTE-LFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLF 618

  Fly   951 ARAPLTLDSDLPPSSAGS-----SKSQQQSNRGNKNAAPFPTGLPKR------------------ 992
            .: |..::|.:.|.|.|.     ......|..|...:|..||.:...
Human   619 NK-PTGMNSSVVPLSQGQVIVSIPTGSTVSAGGGSTSAVSPTSISSSAAAGLQRLAAQSQHVGFA 682

  Fly   993 ---VKLKLSHTG------------KGGV------------------------------------- 1005
               ||||..|..            ||.:
Human   683 RSVVKLKCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCKIEKIVKETVRF 747

  Fly  1006 -GGKKS--GSGTML------------------------PVISTVQSLASGETE------------ 1031
             |..||  ..|..|                        |.:  ||:...|:.|
Human   748 SGADKSFCSEGCKLLYKHDLAKRWGNHCKMCSYCLQTSPKL--VQNNLGGKVEEFCCEECMSKYT 810

  Fly  1032 ------------ARIGNLTVRRK-RGRPR-------------ESGTSSPP-------LSMPGVHP 1063
                        .|.|.|:...| ||..:             :.....||       :||.   .
Human   811 VLFYQMAKCDACKRQGKLSESLKWRGEMKHFCNLLCILMFCNQQSVCDPPSQNNAANISMV---Q 872

  Fly  1064 PAQRGRP--RKHAVDY--------SARSPSPTMSGGSSHMG-IPVRRNTTTTMDFGPATVTETKI 1117
            .|..|.|  ||.:...        ||.:..||::..|...| :|    |.|....|.|: |:|..
Human   873 AASAGPPSLRKDSTPVIANVVSLASAPAAQPTVNSNSVLQGAVP----TVTAKIIGDAS-TQTDA 932

  Fly  1118 ITVPPY--PKAVRNVNISCKPLTVTQGEQCSPDV--RDCATQTEKDYSNKVLIPVPVPIFVPQPM 1178
            :.:||.  |:.::|..:.|||:|.|:...|.|..  ::|.|:........:::|||||:|||.|:
Human   933 LKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSQPQIIVVPVPVPVFVPIPL 997

  Fly  1179 YMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEKH 1243
            ::|:...|||..||:|:|||:.||::.::...:.:.|:.|::|:|..|.||:||.||||:||::.
Human   998 HLYTQYAPVPFGIPVPMPVPMLIPSSMDSEDKVTESIEDIKEKLPTHPFEADLLEMAEMIAEDEE 1062

  Fly  1244 E------SDSDSDNEI-------KPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNPYGDDM 1295
            :      ....|::|:       :.|.|..   |...|||.|....            :.:.:::
Human  1063 KKTLSQGESQTSEHELFLDTKIFEKDQGST---YSGDLESEAVSTP------------HSWEEEL 1112

  Fly  1296 LQIALKM-ATGDYDNH-HQTSTVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDATQR 1358
            ...|||. |..:.|:. .|.|..:.|..:.|:..|......:.|.|             :.|..|
Human  1113 NHYALKSNAVQEADSELKQFSKGETEQDLEADFPSDSFDPLNKGQG-------------IQARSR 1164

  Fly  1359 TARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTFGVNA 1423
            |.|..:.|.             |..|:||.:....|::.:|......|....:.|.|||.:||||
Human  1165 TRRRHRDGF-------------PQPRRRGRKKSIVAVEPRSLIQGAFQGCSVSGMTLKYMYGVNA 1216

  Fly  1424 WKQWVMTKNADIEK------------SSMRRRP------------------------FKTELLQM 1452
            ||.||..|||..|:            ||.|..|                        .|.::|..
Human  1217 WKNWVQWKNAKEEQGDLKCGGVEQASSSPRSDPLGSTQDHALSQESSEPGCRVRSIKLKEDILSC 1281

  Fly  1453 TADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEV 1517
            |..||:..||.|::|||:|||.:|.||:|.||.|||||||:.||||||||.:| |.||...|.::
Human  1282 TFAELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEP-YSRFMIELTKL 1345

  Fly  1518 ARKFSVLYNDSQYIVTRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHI 1582
            .:.:......:.|:.:|:|||||||||||||:||.|||:||:|||||:|.|..|.||::|||:|:
Human  1346 LKIWEPTILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFAHV 1410

  Fly  1583 MKHWKRSSQNSKVPGSRNVLLRFYPPQAGLDANPRKKKV--------------YEQQENEENPLR 1633
            |:..:....::|:     ..|||:||....::.|.|..|              .|..||.:||||
Human  1411 MRRTRTLKYSTKM-----TYLRFFPPLQKQESEPDKLTVGKRKRNEDDEVPVGVEMAENTDNPLR 1470

  Fly  1634 CPVRLYEFYLSKCPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEIN 1697
            |||||||||||||.||||.|||||||||||||||:||:||||..:....|..||.|:.||:|::
Human  1471 CPVRLYEFYLSKCSESVKQRNDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVH 1534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	MDN1	<7..>419	CDD:444083	58/300 (19%)
		TRASH	684..721	CDD:214799	3/36 (8%)
		zf-FCS	724..762	CDD:428958	18/37 (49%)
		DUF3504	1531..1692	CDD:463430	94/174 (54%)
ZMYM4	NP_001362582.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..192		3/26 (12%)
		zf-FCS	339..376	CDD:428958	12/147 (8%)
		TRASH	392..432	CDD:214799	18/39 (46%)
		zf-FCS	484..524	CDD:428958	13/40 (33%)
		TRASH	534..572	CDD:214799	13/38 (34%)
		zf-FCS	686..722	CDD:428958	7/35 (20%)
		zf-FCS	728..763	CDD:428958	5/34 (15%)
		zf-FCS	775..809	CDD:428958	5/35 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1127..1186		16/84 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1234..1263		4/28 (14%)
		DUF3504	1359..1529	CDD:463430	94/174 (54%)