Protein Alignment woc and ZMYM2

DIOPT Version :10

• Sequence 1: NP_001097946.1
• Gene: woc / 47249
• FlyBaseID: FBgn0010328
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: XP_047286540.1
• Gene: ZMYM2 / 7750
• HGNCID: 12989
• Length: 1499
• Species: Homo sapiens
• Alignment Length: 1666
• Identity: 408/1666 - (24%)
• Similarity: 642/1666 - (38%)
• Gaps: 432/1666 - (25%)

  Fly   265 VDENAEETGEAEHGDDTVENVL-------EPEESDVCLIPDDQE-----TEVTEAEKELARENAE 317
            |.:|.|......|....:.|:|       ...|:....:|..:|     :.:|.||.:....:|.
Human    19 VSDNREIEKSPIHLGGKITNILSCNPTKNRQGETKATSLPSLRESWKWFSTMTSAEDDQESPSAL 83

  Fly   318 KAAEEEEAEERQAKTPDNDRKSPADAAADPEDD----------SAAAVDATDVSPTTPTDAQAGA 372
            ..|...|:||.....|.......|.....|..|          |...::.||.:|..     .|:
Human    84 SGASLAESEEENTPIPYMCILLSAVVTWIPSLDLLVFFGMDTSSVGGLELTDQTPVL-----LGS 143

  Fly   373 KSAATGIAE--------ADGVAAAANE-----EEAGGDV--------PDP------DEPTAEESS 410
            .:.||.:..        |:.:.:.:|:     .|...||        |.|      |:.|...:|
Human   144 TAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTS 208

  Fly   411 SAGAGEPGSTPKIIISWIVGSVQKCKQCGDEKNCGFRYRSPEESEEMDKEKENDKAEENAEEGEE 475
            |......|:..||..|        .|:...:|.........::.|:|:..:..:|...|..|...
Human   209 SKNEELQGNDSKITPS--------SKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRP 265

  Fly   476 EEARQKPAAPSGFEYICDTACVDALLEDQPGKYFVRRKKFLVEEVVREEGAAEAEASADGEGGDA 540
            .|.:.:            |..||                |......|    ::..|.....|...
Human   266 PETKNR------------TNDVD----------------FSTSSFSR----SKVNAGMGNSGITT 298

  Fly   541 EEEATPANTQDCLQCKDKTRCKYFIKQDQDCFYICNDDCFNLLNAEEPDKFKLKRH--SIRVRNI 603
            |.::.       :|..:.|..:..:..       .||.  .|.|.:..|...:..|  |::..|:
Human   299 EPDSE-------IQIANVTTLETGVSS-------VNDG--QLENTDGRDMNLMITHVTSLQNTNL 347

  Fly   604 G--------------ATTLQPPQNSPTKRTDG-------SVVARTVEEAETAR-------LDRIE 640
            |              ..|..|...|.||...|       :|.....:..|:|.       :.:..
Human   348 GDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSA 412

  Fly   641 SFRRR----CADCEADINTDEKQLMWETMDFCNEVCLGSYQRT--IGSTCETCKQEVSSIALGKY 699
            ||.|.    ..|..:.:.:..||:...::         ..|.|  :..||..||:.:..   |:.
Human   413 SFPRNQKQPGVDSLSPVASLPKQIFQPSV---------QQQPTKPVKVTCANCKKPLQK---GQT 465

  Fly   700 CVRFGFDVRQFCCAGCLNTFK---KGLKTCSCCQKDISGGQEGFLAPVGDKDQFKDFCSQSCLRR 761
            ..:.......||...||::|.   ...|.|..|:|||:..:...:|.|...:.|::|||.|||..
Human   466 AYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSL 530

  Fly   762 YESMCNPRR-KLRTDVCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAFKFVSNVNADPCAMCSKY 825
            ||...||.: .|....|.:|.....:|.|:..::..|..||:.||:.::..:.:..:.|..|.:|
Human   531 YEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEY 595

  Fly   826 FERRSAESYTIYNEQQSPKVFCSRVCINVYIIVNRH------------------------IVSCQ 866
            ...:.|.:..:..:.|. |.||.:.|::.|..|..|                        :.:|.
Human   596 LPSKGAGNNVLVIDGQQ-KRFCCQSCVSEYKQVGSHPSFLKEVRDHMQDSFLMQPEKYGKLTTCT 659

  Fly   867 WCKVKKYNFDMIYQIGGPHDQETLTCSINCLTMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSD 931
            .|:.:...|||. |..||:......||..|:..|......|......|..|...:.|||..||.|
Human   660 GCRTQCRFFDMT-QCIGPNGYMEPYCSTACMNSHKTKYAKSQSLGIICHFCKRNSLPQYQATMPD 723

  Fly   932 ASMRNFCTYQCVMQFQNQFARAPLTLDSDLPPSSAGSSKSQQQSNRGNKNAAPFPTGLPKRVKLK 996
            ..:.|||...||.:||                     :.|.|.|..|...|       |..::||
Human   724 GKLYNFCNSSCVAKFQ---------------------ALSMQSSPNGQFVA-------PSDIQLK 760

  Fly   997 LSHTGKGGVGGKK--------------------------------------------SGSGTMLP 1017
            .::. |.....|.                                            :.||...|
Human   761 CNYC-KNSFCSKPEILEWENKVHQFCSKTCSDDYKKLHCIVTYCEYCQEEKTLHETVNFSGVKRP 824

  Fly  1018 VIST-VQSLASGETEARIGNLTVR-------RKRGRPRE-------------------------- 1048
            ..|. .:.|...:...|:|...|.       .|:|..:|
Human   825 FCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKFQDWYYKAAR 889

  Fly  1049 ------SGTSSPPLSMPGVHPPAQRGRPRKHAVDY--------SARSPSPTMSGGSSHMGIPVRR 1099
                  .||....:...|         ..||..|.        ....|:.|...|..::......
Human   890 CDCCKSQGTLKERVQWRG---------EMKHFCDQHCLLRFYCQQNEPNMTTQKGPENLHYDQGC 945

  Fly  1100 NTTTTMDFGPATVTETKIITVPPYP---KAVRNVNISCKPLTVTQGEQCSPDVRDCATQTEKDYS 1161
            .|:.|...|.|.         ||.|   |.::|..:.|||||:|:...|.|.::..:.||:..:.
Human   946 QTSRTKMTGSAP---------PPSPTPNKEMKNKAVLCKPLTMTKATYCKPHMQTKSCQTDDTWR 1001

  Fly  1162 NK-VLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMPED 1225
            .: |.:|:|||:::|.||:|||...|||..:|:|:|||:|:|...::::.|...|::::.|:..|
Human  1002 TEYVPVPIPVPVYIPVPMHMYSQNIPVPTTVPVPVPVPVFLPAPLDSSEKIPAAIEELKSKVSSD 1066

  Fly  1226 PLEAELLMMAEMVAEEKHESDSDSDNEIKPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNP 1290
            .|:.|||.|.:|::|::.::::.:.|.:..:..::.    :.|...:..:.|..:.||      |
Human  1067 ALDTELLTMTDMMSEDEGKTETTNINSVIIETDIIG----SDLLKNSDPETQSSMPDV------P 1121

  Fly  1291 YGDDM-LQIALKMATGDYDNHHQTSTVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLD 1354
            |..|: ::|....|..:         :|:|.......:             .|..:.:|
Human  1122 YEPDLDIEIDFPRAAEE---------LDMENEFLLPPV-------------FGEEYEEQ------ 1158

  Fly  1355 ATQRTARGRKRGVGVVMDPPNRNSRSPVKRQR-GGEMDHSALQQQSQQAQQPQEKPDAQMFLKYT 1418
                              |..|:.:...||:. .|...|          ....:..:.....|||
Human  1159 ------------------PRPRSKKKGAKRKAVSGYQSH----------DDSSDNSECSFPFKYT 1195

  Fly  1419 FGVNAWKQWVMTKNAD------IEKSSMRRRPFKTELLQMTADELNYSLCLFVKEVRKPNGTEYA 1477
            :||||||.||.|:..|      .|..|.:....|.:||..|..||||.|..||.|:|:|||..||
Human  1196 YGVNAWKHWVKTRQLDEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYA 1260

  Fly  1478 PDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVARKF--SVLYNDSQYIVTRVEEEHL 1540
            ||:||||.||||:||..:.|.||||.||.|:.|.:.|:::.|.:  |:|.:.|  |.:||||::|
Human  1261 PDSIYYLCLGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGS--IFSRVEEDYL 1323

  Fly  1541 WECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIMKHWKRSS-----------QNSK 1594
            |..||||:|||..||:||.:||||:|.|.|||:|::|||..:.:|||::.           |.|.
Human  1324 WRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACLRYQVSS 1388

  Fly  1595 VPGSRNVLLRFYPPQAGLDANPRK----KKVYEQQENEENPLRCPVRLYEFYLSKCPESVKTRND 1655
            :.|:.|        :..:....||    :.|:||.||..||.||||:::|.||||.|:::..|.|
Human  1389 LCGTDN--------EDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMD 1445

  Fly  1656 VFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEI 1696
            |||||||.|...||||||::.:|.::.|:.||.||.:||:|
Human  1446 VFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDI 1486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	MDN1	<7..>419	CDD:444083	39/202 (19%)
		TRASH	684..721	CDD:214799	9/39 (23%)
		zf-FCS	724..762	CDD:428958	15/37 (41%)
		DUF3504	1531..1692	CDD:463430	79/175 (45%)
ZMYM2	XP_047286540.1	zf-FCS	449..485	CDD:428958	9/38 (24%)
		zf-FCS	490..531	CDD:428958	15/40 (38%)
		zf-FCS	542..578	CDD:428958	10/35 (29%)
		zf-FCS	584..624	CDD:428958	9/40 (23%)
		zf-FCS	653..692	CDD:428958	11/39 (28%)
		zf-FCS	756..793	CDD:428958	4/37 (11%)
		zf-FCS	844..880	CDD:428958	4/35 (11%)
		zf-FCS	886..921	CDD:428958	6/43 (14%)
		DUF3504	1314..1482	CDD:463430	79/175 (45%)