DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment woc and Qrich1

DIOPT Version :9

Sequence 1:	NP_001097946.1	Gene:	woc / 47249	FlyBaseID:	FBgn0010328	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001107591.1	Gene:	Qrich1 / 69232	MGIID:	1916482	Length:	777	Species:	Mus musculus

Alignment Length:	898	Identity:	245/898 - (27%)
Similarity:	374/898 - (41%)	Gaps:	256/898 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 MIYQIGGPHDQETLTCSINCL---------TMHGVSCNI--SARAVTKCDNCSNFNTPQYHLTMS 930
            |:||.||           ||:         ::..::|.:  |.:..|:.:.......||......
Mouse    53 MVYQQGG-----------NCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQV 106

  Fly   931 DA--SMRNFCTYQCVMQFQ-NQFARAPL----TLDSDLPPSSAGSSKSQQQSNRGNKNAAPFPTG 988
            ..  |.:.....|...||. :|.|..|:    .:....|.|:|.|.::....       :|.|:.
Mouse   107 QVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQ-------SPSPSQ 164

  Fly   989 LPKRVKLKLSHTGKGGVGGKKSGSGTMLP-----------VISTVQSLASGETEARIGNLTVRRK 1042
            | :..::::.|     |...:......:|           .:...||||.|:   :|...||
Mouse   165 L-QAAQIQVQH-----VQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQ---QIQIQTV--- 217

  Fly  1043 RGRPRESGTSSPPLSMPGVHPPAQRGRPRKHAVDYSARSPSPTMSGGSSHMGI-----PVRRNTT 1102
                   |..||        ||:|:|.||:                |...:|.     ||::...
Mouse   218 -------GALSP--------PPSQQGSPRE----------------GERRVGTASVLQPVKKRKV 251

  Fly  1103 TTMDFGPATVTETKIITVPPYPKAVRNVNISCKP----LTVTQGEQCS-----PDVRDCATQTEK 1158
            ..    |.||:..                ||.:|    |.:.||:|.|     ||
Mouse   252 DM----PITVSYA----------------ISGQPVATVLAIPQGQQQSYVSLRPD---------- 286

  Fly  1159 DYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMP 1223
                         :......::|||...:..|......:|::....|.
Mouse   287 -------------LLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRG----------------- 321

  Fly  1224 EDPLEAELLMMAEMVAEEK----HESDSDSDNEIKPDPGLVALQYQNSLE------SVAQQQQQQ 1278
             ||.:..:..:|  :.:|.    |.|.|.:        .|.|::.::..|      ||.:...::
Mouse   322 -DPQQQSITHIA--IPQEAYNAVHVSGSPT--------ALAAVKLEDDKEKMVGTTSVVKNSHEE 375

  Fly  1279 QVVDVSGA---GHNPYGDDMLQIALKMATGDYDNHHQTSTVDLETSMTANTISSQSPMGHDGMGQ 1340
            .|..::.:   .....|:..:.:|::...|.|.|..||
Mouse   376 VVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQT--------------------------- 413

  Fly  1341 MGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQ-- 1403
              ||..|.|.   ...|:||:.:        .||      |.::|:..::..||...|..:.:
Mouse   414 --VHIWDPQQ---QPQQQTAQEQ--------TPP------PQQQQQQLQVTCSAQTVQVAEVEPQ 459

  Fly  1404 -QPQEKPDAQM--FLKYTFGVNAWKQWVMTKNADIEKSSMRRRP---------FKTELLQMTADE 1456
             |||..|:..:  .||...|:..||.|..||||::||.:..|..         |:.:|:.....|
Mouse   460 SQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAE 524

  Fly  1457 LNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVARKF 1521
            |||.|||..:|.|...|..|.||.:||:.|.||:||:.|||:|:||.|.||.||||.|.||.:..
Mouse   525 LNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDV 589

  Fly  1522 SVLYNDSQYIV-TRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIMKH 1585
            ........|:: :.|.||.||||||||||||..||:||||||||:|.|.||::||:|:||.:::.
Mouse   590 QPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQ 654

  Fly  1586 WKRSSQNSKVPGSRNVLLRFYPPQAGLDANPRK--KKVY-EQQENEENPLRCPVRLYEFYLSKCP 1647
            .|:|..|   |..::..:| |....|:....:|  ..:| ||.||.|||||||::||:|||.|||
Mouse   655 TKKSPSN---PKDKSTSIR-YLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCP 715

  Fly  1648 ESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEINIAL 1700
            :|||.|||.|||.||....|:||:|||.|.:.::.:.:||.|:.:::||..|:
Mouse   716 QSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAI 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	TRASH	684..721	CDD:214799
		zf-FCS	724..762	CDD:283998
		DUF3504	1531..1690	CDD:288835	82/162 (51%)
Qrich1	NP_001107591.1	CARD	<6..>45	CDD:260018
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164		6/30 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..240		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..440		7/36 (19%)
		DUF3504	606..759	CDD:371846	82/156 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7633
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266757at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.970