Protein Alignment woc and Zmym4

DIOPT Version :10

• Sequence 1: NP_001097946.1
• Gene: woc / 47249
• FlyBaseID: FBgn0010328
• Length: 1703
• Species: Drosophila melanogaster
• Sequence 2: NP_001107871.1
• Gene: Zmym4 / 67785
• MGIID: 1915035
• Length: 1549
• Species: Mus musculus
• Alignment Length: 1806
• Identity: 461/1806 - (25%)
• Similarity: 690/1806 - (38%)
• Gaps: 560/1806 - (31%)

  Fly   176 EGEVDAEGEAEQEAEDDAALDREATDDVDMQSVGADSHQAEDAEPPEGRDEVDTSLEEQENGQDP 240
            |.||:.......|.:.||..| |..::..:.    |:..:||.:     ..:..:|.....|...
Mouse     3 EREVETGPRKRFEQKSDAVFD-EIVENCGVM----DTEMSEDTD-----HNLTPTLASMSYGMPN 57

  Fly   241 DEREKDAAADEDD-----------PDAEGDAESEQ-------------VDENAEETGEAEHGDDT 281
            ....:::..||||           |....|.|.||             .|.:.|....|.|.:..
Mouse    58 QTGSENSLLDEDDYFLNSGDLAGIPVVSSDNEDEQDCSSKDNLVSSVHTDGSLEVERRAAHQESD 122

  Fly   282 VENVLE---------PEE-----------SDVCLIPDDQETEVTEAEKELARENAEKAAEEEEAE 326
            .||.::         |::           .|.||:.::.:...:..||     |.:....|.|..
Mouse   123 NENEIQIQNQLKKDFPKQFDQVSVFKSIRKDFCLVRENSKETFSGKEK-----NRDLTYHEREKR 182

  Fly   327 -ERQAKTPDNDRKSP-ADAAADPEDDSAAAVDATDVSPTTPTDAQAGAKSAATGIAEADGVAAAA 389
             ::..|..|:..||. .|.||:..:::        :....|.:.:...:.::...|..:.:.:..
Mouse   183 LDKPHKGLDSRLKSSFFDKAANQVEET--------LHTHLPQNPETNFRDSSYPFASKESIGSEL 239

  Fly   390 NEEEAGGDVPDPDEPTAEESSSAGAGEPGSTPKIIISWIVGSVQKCKQCGDEKNCGFRYRSPEES 454
            ....| .::...:||..:|...|.|.:.|...::               .||         |:.:
Mouse   240 GNSFA-SNIRIKEEPLDDEYDRAVAPQQGLLDRV---------------KDE---------PDNA 279

  Fly   455 EEMDKEKENDKAEENAEEGEEE-----EARQKPAAP---SGFEYICDTACVDALLEDQPGKYFVR 511
            :|....:     ::..:|||.:     .....|.||   :||:....:..::.:|...|
Mouse   280 QEYSHGQ-----QQKTQEGELKISAVFSVSGSPLAPQLTTGFQPSLASPGMNKMLPSVP------ 333

  Fly   512 RKKFLVEEVVREEGAAEAEASADGEGGDAEEEATPANTQDCLQCKDKTRCKYFIKQDQDCFYICN 576
                          |.....|..|                         ||..:::.|..:
Mouse   334 --------------ATAVRVSCSG-------------------------CKKILQKGQTAY---- 355

  Fly   577 DDCFNLLNAEEPDKFKLKRHSIRVRNIGATTLQPPQNSPTKRTDGSVVARTVEEAETARLDRIES 641
                                    :..|:|.|
Mouse   356 ------------------------QRKGSTQL--------------------------------- 363

  Fly   642 FRRRCADCEADINTDEKQLMWETMDFCNEVCLGSYQRTIGSTCETCKQEVSSIALGKYCVRFGFD 706
                                     ||:.:||..|         |.........|.|
Mouse   364 -------------------------FCSTLCLTGY---------TVPPARPPPPLTK-------- 386

  Fly   707 VRQFCCAGCLNTFKKGLKTCSCCQKDISGGQEGFLAPVGDKDQFKDFCSQSCLRRYESMCNPRRK 771
                             ||||.|.|||...::...|...:....|||||||||..||....|...
Mouse   387 -----------------KTCSSCSKDILNPKDVISAQFENSTTSKDFCSQSCLSTYELKKKPIVT 434

  Fly   772 LRTD----VCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAFKFVSNVNADPCAMCSKYFERRSAE 832
            :.|:    .|.:|.....:|.|:..::..|..||:.|||.|:..:|:..:.|..|..|....|.:
Mouse   435 INTNSISTKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENCGGYCYSGSGQ 499

  Fly   833 SYTIYNEQQSPKVFCSRVCINVYIIVNRHIVSCQWCKVKKYNFDMIYQIGGPHDQETLTCSINCL 897
            .:.:..|.||.| |||.:|:..|...:..|..|..||..:.:.:||.........| |.||:|||
Mouse   500 CHVLQIEGQSKK-FCSSMCVTSYKQKSAKITPCALCKSLRSSAEMIENTNSLGKTE-LFCSVNCL 562

  Fly   898 TMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQNQFARAPLTLDSDLP 962
            :.:.|....||....:|::|.....|||||.|||.|:||||:|.||:.|||.|.: |..::|.:.
Mouse   563 SAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVVAFQNLFNK-PTGMNSSVV 626

  Fly   963 PSSAGS-----SKSQQQSNRGNKNAAPFPT--------GLPKR-------------VKLKLSHTG 1001
            |.|.|.     ......|..|....|..||        ||.:.             |||:..|..
Mouse   627 PLSQGQVIVSIPTGSSASAGGGSTPAVSPTSINSSAAAGLQRLAAQSQHVGFARSVVKLRCQHCN 691

  Fly  1002 K----------------------------------------------------GGVG-------- 1006
            :                                                    .|..
Mouse   692 RLFATKPELLDYKGKMFQFCGKNCCDEYKKINNVMAMCEYCKIEKIIKETVRFSGADKSFCSEGC 756

  Fly  1007 --------GKKSGSGTML--------PVISTVQSLASGETE------------------------ 1031
                    ||:.||...:        |.:  :|:...|:.|
Mouse   757 KLLYKHDLGKRWGSHCKMCSYCLQTSPKL--IQNNLGGKVEDFCCEECMSKYTVLFYQMAKCDGC 819

  Fly  1032 ARIGNLTVRRK-RGRPR-------------ESGTSSPPLSMPGVH-----PPAQRGRP--RKHAV 1075
            .|.|.|:...| ||..:             :.....|||....|.     ..|..|.|  ||.:.
Mouse   820 KRQGKLSESLKWRGDIKHFCNLLCILMFCHQQTVCDPPLQNNAVASISMVQAASAGPPSLRKDST 884

  Fly  1076 DY--------SARSPSPTMSGGSSHMG-IPVRRNTTTTMDFGPATVTETKIITVPPY--PKAVRN 1129
            ..        ||.:..||.:..|...| :|    |.|....|.|: |:|..:.:||.  |:.::|
Mouse   885 PVIANVVSLASAPAAQPTANTNSVLQGAVP----TVTAKIIGDAS-TQTDALKLPPSQPPRLLKN 944

  Fly  1130 VNISCKPLTVTQGEQCSPDV--RDCATQTEKDYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIP 1192
            ..:.|||:|.|:...|.|..  ::|.|.|..: ...:::|||||:|||.|:::|:...|||..||
Mouse   945 KALLCKPITQTKATSCKPHTQNKECQTDTPSE-PQVMVVPVPVPVFVPIPLHLYTQYTPVPFGIP 1008

  Fly  1193 LPIPVPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEKHESDSDSDNE----- 1252
            :|:|||:|||::.:..:...:.|:.|::|:...|.||:||.||||:||::.:..:.|..|
Mouse  1009 VPMPVPMFIPSSMDNDEKATEGIEDIKEKLATHPFEADLLEMAEMIAEDEEKEKTLSQGESQTSE 1073

  Fly  1253 ---------IKPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNPYGDDMLQIALKM-ATGDY 1307
                     .:.|.|..   |...|||.|....            :.:.:::...|||. |..|.
Mouse  1074 QELFLDTKIFEKDQGST---YSGDLESEAVSTP------------HSWEEELNHYALKSNAVQDA 1123

  Fly  1308 DNHHQT-STVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDATQRTARGRKRGVGVVM 1371
            |:..:. |..:.|..:.|:..|......:.|.| :......::.|.....|...||||:.| |.:
Mouse  1124 DSELKPFSKGETEQDLEADFPSESFDPLNKGQG-IQARSRTRRRHRDGFPQPRRRGRKKSV-VPV 1186

  Fly  1372 DPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTFGVNAWKQWVMTKNADIE 1436
            :|     ||.::         .|||..|...          |.|||.:||||||.||..|||..|
Mouse  1187 EP-----RSLIQ---------GALQGCSVSG----------MTLKYMYGVNAWKNWVQWKNAKDE 1227

  Fly  1437 KSSM------------------------------------RRRPFKTELLQMTADELNYSLCLFV 1465
            :..:                                    |....|.::|..|..||:..||.|:
Mouse  1228 QGDLKCGGGELASASPCSDSLGSAQDHALSQESSEQGCKARSVKLKEDILSCTFSELSLGLCQFI 1292

  Fly  1466 KEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVARKFSVLYNDSQY 1530
            :|||:|||.:|.||:|.||.|||||||:.||||||||.:| |.||...|.::.:.:......:.|
Mouse  1293 QEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEP-YSRFMIELTKLLKIWEPTILPNGY 1356

  Fly  1531 IVTRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIMKHWKRSSQNSKV 1595
            :.:|:|||||||||||||:||.|||:||:|||||:|.|..|.||::|||:|:|:..:....::|:
Mouse  1357 MFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLRNVTEHLKLSFAHVMRRTRTLKYSTKM 1421

  Fly  1596 PGSRNVLLRFYPPQAGLDANPRKKKV--------------YEQQENEENPLRCPVRLYEFYLSKC 1646
                 ..|||:||....::.|.|..:              .|..||.:|||||||||||||||||
Mouse  1422 -----TYLRFFPPLQKPESEPDKVTIGKRKRNEDDEAPVGVEMAENTDNPLRCPVRLYEFYLSKC 1481

  Fly  1647 PESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEIN 1697
            .||||.|:|||||||||||||:||:||||..:....|..||.|:.||:|::
Mouse  1482 SESVKQRSDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVREVH 1532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	MDN1	<7..>419	CDD:444083	52/288 (18%)
		TRASH	684..721	CDD:214799	3/36 (8%)
		zf-FCS	724..762	CDD:428958	18/37 (49%)
		DUF3504	1531..1692	CDD:463430	92/174 (53%)
Zmym4	NP_001107871.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..108		4/24 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..291		5/52 (10%)
		zf-FCS	336..373	CDD:428958	12/147 (8%)
		TRASH	389..429	CDD:214799	18/39 (46%)
		zf-FCS	481..521	CDD:428958	12/40 (30%)
		TRASH	531..569	CDD:214799	13/38 (34%)
		zf-FCS	683..719	CDD:428958	4/35 (11%)
		zf-FCS	725..760	CDD:428958	1/34 (3%)
		zf-FCS	772..806	CDD:428958	4/35 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1124..1185		14/62 (23%)
		DUF3504	1357..1527	CDD:463430	92/174 (53%)