DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment woc and zmym2

DIOPT Version :9

Sequence 1:	NP_001097946.1	Gene:	woc / 47249	FlyBaseID:	FBgn0010328	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_001923572.4	Gene:	zmym2 / 570149	ZFINID:	ZDB-GENE-030131-2408	Length:	1357	Species:	Danio rerio

Alignment Length:	1589	Identity:	398/1589 - (25%)
Similarity:	635/1589 - (39%)	Gaps:	393/1589 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 EGDAESE-QVDENAEETGEAEHGDDTVENVLEP----EES----DVCLIPDDQETEVTEAEKELA 312
            :||.|:. .|:|....|||.|...:|...: ||    |||    |:....:|.:.:|...|
Zfish     2 DGDLEARADVEEACTVTGEEEGQMETTPEI-EPSPSAEESQTAPDLPTASEDNDDDVVLVE---- 61

  Fly   313 RENAEKAAEEEEAEERQAKTPDNDRKSPADAAADPEDDSAAAVDATDVSPTTPTDAQAGAKSAAT 377
                |..|..:...:....||.....:..|.|     :||....|...||:.|:.|.....:|:|
Zfish    62 ----EPPAHSQGKVQPPISTPAETLDAAKDCA-----ESATTATAPSKSPSPPSSAATSGTTAST 117

  Fly   378 GIAEADGVAAAANEEE-------AGGDVPDPDEPTAEESSSAGAGEPGSTPKIIISWIVGSVQKC 435
             .|::.......::||       |...||.|:...|..|:     ||.|..:|.....:|
Zfish   118 -TAKSQSEPIVIDDEEDSELKGTASSSVPPPEVEDALSST-----EPDSEIQIASVTTLG----- 171

  Fly   436 KQCGDEKNCGFRYRSPEESEEMDKEKENDKAEENAEEGEEEEARQKPAAPSGFEYICDTACVDAL 500
                          :...:..||....:..|                        :|....::.:
Zfish   172 --------------TDSSAVAMDTSTASPLA------------------------LCAQEDINLM 198

  Fly   501 LEDQPGKYFVRRKKFLVEEVVREEGAAEAEASADGEGGDAEEEATPANTQDCLQCKDKTRCKYFI 565
            :                         ....:..||:|..|.........::.||.
Zfish   199 I-------------------------TNVTSLKDGDGPAAAPLEELEGAENGLQI---------- 228

  Fly   566 KQDQDCFYICNDDCFNLLNAEEPDKFKLKRHSIRVRNIGATTLQPPQNSPTKRTDGSVVARTVEE 630
                       ...|: ||.|..            :|.|.|....|..:|.:.   |..::.|:.
Zfish   229 -----------SSAFS-LNPEAQ------------QNQGTTGRPSPTFNPGRI---SAASQPVQN 266

  Fly   631 AETARLDRIESFRRRCADCEADINTDEKQLMWETMDF-----------CNEVCLGSYQ--RTIGS 682
            .||....|.:|:..:    .|....::||   ..:|.           |..  .||.|  ||:..
Zfish   267 GETGTHQRSDSWISQ----SASFPRNQKQ---PGVDSPSPAAPLPKPPCQS--SGSQQPPRTMKV 322

  Fly   683 TCETCKQEVSSIALGKYCVRFGFDVRQFCCAGCLNTFK---KGLKTCSCCQKDISGGQEG-FLAP 743
            ||..||:.:..   |:...:.......||...||:.|.   ...|:|:.|:|||:..:.| .:|.
Zfish   323 TCANCKKPLKK---GQTAYQRKGSSHLFCSTTCLSAFSHKPAPKKSCTMCKKDITNMKGGTIVAQ 384

  Fly   744 VGDKDQFKDFCSQSCLRRYESMCNPRRKLRTDVCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAF 808
            |...:.|::|||..||..||:..||::......|.||.....:|.|:.:::..|..||:.||:.:
Zfish   385 VDSSESFQEFCSTGCLAAYENKQNPQKNQIKTKCTVCGKLTEIRHEVSIKNVTHKICSDACFNRY 449

  Fly   809 KFVSNVNADPCAMCSKYFERRSAESYTIYNEQQSPKVFCSRVCINVYIIVNRHIVSCQWCKVKKY 873
            :..:.:..:.|..|..|...|:..::.:..:.|. |.||.:.||..|...:..||.|..|||...
Zfish   450 RMANGLVMNCCEQCGNYLPSRATANHVLLIDGQQ-KRFCCQNCIRDYKQTHGKIVQCSGCKVMCR 513

  Fly   874 NFDMIYQIGGPHDQETLTCSINCLTMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFC 938
            :||....||.....|:. |:..|:|....:. .:..:...|..|.....|||..|:.:..:.:||
Zfish   514 SFDATQCIGANGAMESY-CTTACMTKSKFTA-AAQNSEPSCHFCKRNALPQYQATLPEGKVLSFC 576

  Fly   939 TYQCVMQFQNQFARAPLTLDSDLPPSSAGSSKSQQQSNRGNKNAAP------------------- 984
            :.|||.:|||  |....:.:..||.|::...:.:....|.:.:..|
Zfish   577 SSQCVTKFQN--ATIQTSTNGQLPASASEDIQLKCNYCRSSFSLKPEVLEWEDKVYQFCSKTCCE 639

  Fly   985 ------------------------------------------FPTGLPKRVKLKLSHTGKGGVGG 1007
                                                      |.....:|:.||...........
Zfish   640 DYKKLHCIVTFCEFCQEEKTLHETVKFSGVKRPFCSEGCKLLFKQDFIRRLGLKCVTCNHCTQMC 704

  Fly  1008 KKSGSGTMLPVISTVQSLASGETEAR-----------------IGNLTVR-RKRGRPRESGTSSP 1054
            |||    :...|..|......||.|:                 .||||.. :.|...::......
Zfish   705 KKS----VTKQIDGVSRDFCSETCAKKFHDWYYKAARCDCCKVQGNLTESVQWRAELKQFCDQQC 765

  Fly  1055 PLSMPGVHPPAQRGRPRKHAVDYSARSPSPTMSGGSSHMGIPVRRNTTTTMDFGPATVTETKIIT 1119
            .|..     ..|:..|..    .:.:.|..|..|    .|.|     |.|...||.:.....|:
Zfish   766 LLRF-----YCQQNEPNM----ATQKGPENTALG----FGGP-----TQTSKMGPVSYAGGGIL- 811

  Fly  1120 VPPYPKAVRNVNISCKPLTVTQGEQCSPDVRDCATQTE--------KDYSNKVLIPVPVPIFVPQ 1176
                 |.|:|..:.|||||:|:...|.|.::....||:        |:|   :.||:|||::||.
Zfish   812 -----KDVKNKAVLCKPLTMTKATYCKPHMQSKPLQTDEADLESSGKEY---IPIPIPVPVYVPV 868

  Fly  1177 PMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEE 1241
            ||.:||...|....||:|:|||:|:|||...|:.|:|.|::::.|:|.|||||:|:.|||::|:
Zfish   869 PMNLYSQATPTSFAIPVPVPVPVFLPTTLQNAEQIVKTIRELKAKVPSDPLEADLIAMAEVIAQ- 932

  Fly  1242 KHESDSDSDNEIKPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAG------HNPYGDDM-LQIA 1299
              |.:....:.||.:.|    ..:..:|.|.|:         :|:|      .:.|..|: |:..
Zfish   933 --EDEKPKCSNIKCEKG----SSEEKMEIVKQE---------NGSGSSEEEEEDKYEPDLDLEKD 982

  Fly  1300 LKMATGDYDNHHQTSTVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDATQRTARGRK 1364
            |.:|          |...|...:...|:.|..|:                  :.:..::|.|.|.
Zfish   983 LPLA----------SEPVLVERLDTETLFSLPPV------------------LAEEKEKTPRTRT 1019

  Fly  1365 RGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTFGVNAWKQWVM 1429
            |..|              :::|..|.:.|:....|..|:  ....|:...|...:|:|||::|..
Zfish  1020 RRRG--------------QKRRAVEEESSSSLSSSPAAE--SSAVDSSFPLSSRYGLNAWRRWAT 1068

  Fly  1430 TKNADIE-KSSMRRR-PFKTELLQMTADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYL 1492
            |:::..: |.|.::. ..|:.||.::.:|||.||..||||||:|||..|:||::.||.||||::|
Zfish  1069 TEDSPSKGKESQKQAVSLKSSLLSLSQEELNQSLSRFVKEVRRPNGEHYSPDSLLYLCLGIQKHL 1133

  Fly  1493 YVNGRIDNIFYDPYYERFTECLDEVARKF--SVLYNDSQYIVTRVEEEHLWECKQLGAHSPHVLL 1555
            ...||.|::|.|..||.|.|.|:::.:.:  |||.:.|::  :||||::||...|||..:|.|||
Zfish  1134 QDKGRTDDLFNDSQYEMFGEELNKLLKDWQPSVLPDGSRW--SRVEEQYLWSSGQLGEQAPSVLL 1196

  Fly  1556 STLMFFNTKHFNLTTVEEHMQLSFSHIMKHWKRSSQNSKVPGSRNVLLRFYPP--------QAGL 1612
            .::.:.|||:|.|.|.|:|::|||:::.      ..:|..|.|....:....|        |:|
Zfish  1197 RSVFYLNTKYFGLRTPEQHLRLSFANVY------GPSSSKPHSHETTVCIRIPSISQEQHEQSG- 1254

  Fly  1613 DANPRKKKVY-----EQQENEENPLRCPV-----RLYEFYLSKCPESVKTRNDVFYLQPERSCVP 1667
              :.|::|.|     :..........|||     ||||.|||||||||:.|.|.||::||.|...
Zfish  1255 --SKRRRKDYCDSNFDSDSGSGGSAHCPVKKHECRLYELYLSKCPESVRQRTDFFYMKPEVSASS 1317

  Fly  1668 DSPVWYSTQALGQDALQRMLHRVKMVKEI 1696
            |||:|:|:..|.:..|.|:|.|..:|:|:
Zfish  1318 DSPLWFSSTPLEKSVLSRLLTRALLVREV 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	TRASH	684..721	CDD:214799	9/39 (23%)
		zf-FCS	724..762	CDD:283998	15/38 (39%)
		DUF3504	1531..1690	CDD:288835	65/176 (37%)
zmym2	XP_001923572.4	zf-FCS	316..356	CDD:283998	11/42 (26%)
		zf-FCS	358..403	CDD:283998	15/44 (34%)
		zf-FCS	452..495	CDD:283998	10/43 (23%)
		zf-FCS	604..641	CDD:283998	2/36 (6%)
		zf-FCS	689..728	CDD:283998	11/42 (26%)
		DUF3504	1173..1341	CDD:288835	66/178 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMKN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266757at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103093
Panther	1	1.100	-	-	O	PTHR45736
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X789
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.910