DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment woc and qrich1

DIOPT Version :9

Sequence 1:	NP_001097946.1	Gene:	woc / 47249	FlyBaseID:	FBgn0010328	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	NP_001020633.1	Gene:	qrich1 / 336260	ZFINID:	ZDB-GENE-030131-8204	Length:	717	Species:	Danio rerio

Alignment Length:	722	Identity:	203/722 - (28%)
Similarity:	315/722 - (43%)	Gaps:	176/722 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1013 GTMLPVISTVQSLASGETEARI---GNLTVRRKRGRPRE-----SGTSSPPLSMPGVHPPAQRGR 1069
            |.:|.|.|..|....|.|..::   |.||..:::....:     :|.....:.......|.|:|.
Zfish   122 GQVLQVASPTQQQLQGVTTTQLVQQGELTEEQQQQIQAQLVAAVAGGQQIQIQTVEALSPQQQGS 186

  Fly  1070 PRKHAVDYSARSPSPTMSGGSSHMGIPVRRNTTTTMDFGPATVTETKIITVPPY--PKAVRNVNI 1132
            ||:  ||                     ||...:.....||...:..:.||..|  |:..:...:
Zfish   187 PRE--VD---------------------RRTGASPAVLQPAKKRKVDVPTVVSYSLPQGQQLATV 228

  Fly  1133 SCKPLTVTQGEQ-----CSPDVRDCATQTEKDYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIP 1192
                |.:.||:|     ..||                       :......::|||...:..|..
Zfish   229 ----LAIPQGQQQGYLSLRPD-----------------------LLTVDSTHLYSATGTITGPAG 266

  Fly  1193 LPIPVPIF-IPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEKHESDSDSDNEI--- 1253
            ....:|:: .|..:..|...:             |.||     ...|..:...:|.|.|..|
Zfish   267 ETWTIPVYSAPQQQGVAHIAI-------------PQEA-----YSTVQVQASPTDKDKDKMIIGA 313

  Fly  1254 KPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNPYGDDMLQIALKMATGDYDNHHQTSTVDL 1318
            ....|.||:...:|..:.     |::||..........|:..:.:|::...|.|
Zfish   314 SQAAGAVAVPVSSSGVTT-----QEEVVHSLFPAQFMNGNIHIPVAVQTVGGAY----------- 362

  Fly  1319 ETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVK 1383
              |.|...:....|.             .||.|:.|
Zfish   363 --SGTTQALHIWDPQ-------------QQQQHVQD----------------------------- 383

  Fly  1384 RQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTF----GVNAWKQWVMTKNADIEKSSM---- 1440
                ||:....|..|:|...:||.:|..::.|..|.    |:..|:.||..|||:::|:..
Zfish   384 ----GEVQEQQLHLQAQTEAEPQVEPPPELVLPNTLKPEDGLEVWRLWVQRKNAELDKNEQNKLA 444

  Fly  1441 ---RRRP--FKTELLQMTADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDN 1500
               ||:|  |:.:|:..:..|||.:|.|..:|.|...|..:.||::||:.|.||:|::.|||:|:
Zfish   445 PIGRRQPLRFQDDLVSSSVGELNLALSLMTQEARGLEGELFEPDSLYYVFLCIQKYMFENGRVDD 509

  Fly  1501 IFYDPYYERFTECLDEVARKFSVLYNDSQYIV-TRVEEEHLWECKQLGAHSPHVLLSTLMFFNTK 1564
            ||.|.||.||.:||.::..::....:...||: :.|.||.||||||||||||..||:|||:||||
Zfish   510 IFSDQYYSRFCQCLHKILEEWRPSIHPLGYIIPSHVTEEMLWECKQLGAHSPATLLTTLMYFNTK 574

  Fly  1565 HFNLTTVEEHMQLSFSHIMKHWKRSSQNSKVPGSRNVLLRFYPPQAGLDANPRKKKV-----YEQ 1624
            :|:|||||:||:::||.:::|.|::..|   |..::..:|:.   .|:..:...:||     .||
Zfish   575 YFHLTTVEQHMKVAFSKVLRHTKKNPTN---PKDKSTSIRYL---KGVGPHHVGQKVTDDMYAEQ 633

  Fly  1625 QENEENPLRCPVRLYEFYLSKCPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHR 1689
            .|:.|||||||::||:|||.|||::.|.|||.:||.||....|:||:|||||.:..:.|:.||.|
Zfish   634 AEDPENPLRCPIKLYDFYLFKCPQTAKGRNDTYYLTPEPVVAPNSPIWYSTQPITSEQLEHMLTR 698

  Fly  1690 VKMVKEI 1696
            :.||:||
Zfish   699 IMMVREI 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	TRASH	684..721	CDD:214799
		zf-FCS	724..762	CDD:283998
		DUF3504	1531..1690	CDD:288835	80/164 (49%)
qrich1	NP_001020633.1	DUF3504	541..699	CDD:314827	79/163 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266757at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45736
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020