DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment woc and Zmym4

DIOPT Version :9

Sequence 1:	NP_001097946.1	Gene:	woc / 47249	FlyBaseID:	FBgn0010328	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_017448891.1	Gene:	Zmym4 / 313598	RGDID:	1309545	Length:	1561	Species:	Rattus norvegicus

Alignment Length:	1822	Identity:	469/1822 - (25%)
Similarity:	688/1822 - (37%)	Gaps:	569/1822 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 VDG-GPASPEAMDVDEGEVDAEGEAEQ-EAEDDAALDREATDDVDMQSVGADSHQAEDAEPPEGR 224
            ||| ....|||         |.|...| |.:.||..| |..::..:.    |:..:||.:
  Rat     6 VDGLREGRPEA---------APGSTRQFEQKSDAVFD-EIVENCGVM----DTEMSEDTD----- 51

  Fly   225 DEVDTSLEEQENGQDPDEREKDAAADEDD-----------PDAEGDAESEQ-------------V 265
            ..:..:|.....|.......:::..||||           |....|.|.||             .
  Rat    52 HNLTPTLASMSYGMPSQTGSENSLLDEDDYFLNSGDLAGIPVVSSDNEDEQDFSSKDNLVSSAHT 116

  Fly   266 DENAEETGEAEHGDDTVENVLE---------PEE-----------SDVCLIPDDQETEVTEAEKE 310
            |.:.|....|.|.:...||.::         |::           .|.||:.::.:...:..||
  Rat   117 DGSLEIERRASHHESDNENEIQIQSQLKKDFPKQFDQVSVFKSIRKDFCLVRENSKETFSGKEK- 180

  Fly   311 LARENAEKAAEEEEAE-ERQAKTPDNDRKSP-ADAAADPEDDSAAAVDATDVSPTTPTDAQAGAK 373
                |.:....|.|.. ::..|..|:..||. .|.||:..:::        :....|.:.:...:
  Rat   181 ----NRDLTYHEREKRLDKPHKGLDSRLKSSFFDKAANQVEET--------LHTHLPQNPETNFR 233

  Fly   374 SAATGIAEADGVAAAANEEEAGGDVPDPDEPTAEESSSAGAGEPGSTPKIIISWIVGSVQKCKQC 438
            .::...|..:.:.:......| .::...:||..:|...|.|.:.|...::
  Rat   234 DSSYPFANKESIGSELGNSFA-SNIRIKEEPLDDEYDKAVAPQQGLLDRV--------------- 282

  Fly   439 GDEKNCGFRYRSPEESEEMDKEKENDKAEENAEEGEEEEARQKPAAPSGFEYICDTACVDALLED 503
                                 :.|.|.|:|.. .|::::.
  Rat   283 ---------------------KDEPDNAQEYG-HGQQQKT------------------------- 300

  Fly   504 QPGKYFVRRKKFLVEEVVREEGAAEAEASADGEGGDAEEEATPANTQDCLQCKDKTRCKYFIKQD 568
                               :||..:..|.....|.....:.|
  Rat   301 -------------------QEGELKISAVFSVSGSPLAPQLT----------------------- 323

  Fly   569 QDCFYICNDDCFNLLNAEEPDKFKLKRHSIRVRNIGATTLQPPQNSPTKRTDGSVVARTVEEAET 633
                                                 |..||...||........|..|
  Rat   324 -------------------------------------TGFQPSLASPGMNKMLPAVPAT------ 345

  Fly   634 ARLDRIESFRRRCADCEADINTDEK--QLMWETMDFCNEVCLGSYQRTIGSTCETCKQEVSSIAL 696
                   :.|..|:.|:..:...:.  |....|..||:.:||..|         |.........|
  Rat   346 -------AIRVSCSGCKKILQKGQTAYQRKGSTQLFCSTLCLTGY---------TVPPARPPPPL 394

  Fly   697 GKYCVRFGFDVRQFCCAGCLNTFKKGLKTCSCCQKDISGGQEGFLAPVGDKDQFKDFCSQSCLRR 761
            .|                         ||||.|.|||...::...|...:....|||||||||..
  Rat   395 TK-------------------------KTCSSCSKDILNPKDVISAQFENSTTSKDFCSQSCLST 434

  Fly   762 YESMCNPRRKLRTD----VCGVCNNQKPVRVEMLLEDREHYFCSNPCFSAFKFVSNVNADPCAMC 822
            ||....|...:.|:    .|.:|.....:|.|:..::..|..||:.|||.|:..:|:..:.|..|
  Rat   435 YELKKKPIVTINTNSISTKCSMCQKNAVIRHEVNYQNVVHKLCSDACFSKFRSANNLTMNCCENC 499

  Fly   823 SKYFERRSAESYTIYNEQQSPKVFCSRVCINVYIIVNRHIVSCQWCKVKKYNFDMIYQIGGPHDQ 887
            ..|....|.:.:.:..|.||.| |||.:|:..|...:..|..|..||..:.:.:||.........
  Rat   500 GGYCYSGSGQCHVLQIEGQSKK-FCSSMCVTSYKQKSAKITPCALCKSLRSSAEMIENTNSLGKT 563

  Fly   888 ETLTCSINCLTMHGVSCNISARAVTKCDNCSNFNTPQYHLTMSDASMRNFCTYQCVMQFQNQFAR 952
            | |.||:|||:.:.|....||....:|::|.....|||||.|||.|:||||:|.||:.|||.|.:
  Rat   564 E-LFCSVNCLSAYRVKMVTSAGVQVQCNSCKTSAIPQYHLAMSDGSIRNFCSYSCVLAFQNLFNK 627

  Fly   953 APLTLDSDLPPSSAGS-----SKSQQQSNRGNKNAAPFPT---------GLPKR----------- 992
             |..::|.:.|.|.|.     ......|..|....|..||         ||.:.
  Rat   628 -PTGMNSSVVPLSQGQVIVSIPTGSSASAGGGSTPAASPTSVHSSSAAAGLQRLAAQSQHVGFAR 691

  Fly   993 --VKLKLSHTGK----------------------------------------------------G 1003
              |||:..|..:                                                    .
  Rat   692 SVVKLRCQHCNRLFATKPELLDYKGKMFQFCGKNCSDEYKKINNVMAMCEYCKIEKIIKETVRFS 756

  Fly  1004 GVG----------------GKKSGSGTML--------PVISTVQSLASGETE------------- 1031
            |..                ||:.||...:        |.:  :|:...|:.|
  Rat   757 GADKSFCSEGCKLLYKHDLGKRWGSHCKMCSYCLQTSPKL--IQNNLGGKVEDFCCEECMSKYTV 819

  Fly  1032 -----------ARIGNLTVRRK-RG----------------------RPRESGTSSPPLSMPGVH 1062
                       .|.|.|:...| ||                      .|.::.|:|  :||.
  Rat   820 LFYQMAKCDGCKRQGKLSESLKWRGDIKHFCNLLCILMFCHQQTVCDPPLQNNTAS--ISMV--- 879

  Fly  1063 PPAQRGRP--RKHAVDY--------SARSPSPTMSGGSSHMG-IPVRRNTTTTMDFGPATVTETK 1116
            ..|..|.|  ||.:...        ||.:..||.:..|...| :|    |.|....|.|: |:|.
  Rat   880 QAASAGPPSLRKDSTPVIANVVSLASAPAAQPTANANSVLQGAVP----TVTAKIIGDAS-TQTD 939

  Fly  1117 IITVPPY--PKAVRNVNISCKPLTVTQGEQCSPDV--RDCATQTEKDYSNKVLIPVPVPIFVPQP 1177
            .:.:||.  |:.::|..:.|||:|.|:...|.|..  ::|.|:........:::|||||:|||.|
  Rat   940 ALKLPPSQPPRLLKNKALLCKPITQTKATSCKPHTQNKECQTEDTPSEPQVMVVPVPVPVFVPIP 1004

  Fly  1178 MYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMPEDPLEAELLMMAEMVAEEK 1242
            :::|:...|||..||:|:|||:|||::.|..:...:.|:.|::|:...|.||:||.||||:||::
  Rat  1005 LHLYTQYTPVPFGIPVPMPVPMFIPSSMNNEEKASEGIEDIKEKLATHPFEADLLEMAEMIAEDE 1069

  Fly  1243 HESDSDSDNE--------------IKPDPGLVALQYQNSLESVAQQQQQQQVVDVSGAGHNPYGD 1293
            .:..:.|..|              .:.|.|..   |...|||.|....            :.:.:
  Rat  1070 EKEKTLSQGESQTSEQELFLDTKIFEKDQGST---YSGDLESEAVSTP------------HSWEE 1119

  Fly  1294 DMLQIALKM-ATGDYDNH-HQTSTVDLETSMTANTISSQSPMGHDGMGQMGVHHLDQQHHMLDAT 1356
            ::...|||. |..|.|:. .|.|..:.|..:.|:..|......:.|.| :......::.|.....
  Rat  1120 ELNHYALKSNAVQDADSELKQFSKGETEQDLEADFPSESFDPLNKGQG-IQARSRTRRRHRDGFP 1183

  Fly  1357 QRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQQPQEKPDAQMFLKYTFGV 1421
            |...||||:.| |.::|     ||.::         .|||..|...          |.|||.:||
  Rat  1184 QPRRRGRKKSV-VPVEP-----RSLIQ---------GALQGCSVSG----------MTLKYMYGV 1223

  Fly  1422 NAWKQWVMTKNADIEKSSM------------------------------------RRRPFKTELL 1450
            ||||.||..|||..|:..:                                    |....|.::|
  Rat  1224 NAWKNWVQWKNAKDEQGDLKCGGGEHASASPCSDSLGSAQDQALSQESSEQGCKVRSMKLKEDIL 1288

  Fly  1451 QMTADELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLD 1515
            ..|..||:..||.|::|||:|||.:|.||:|.||.|||||||:.||||||||.:| |.||...|.
  Rat  1289 SCTFSELSLGLCQFIQEVRRPNGEKYDPDSILYLCLGIQQYLFENGRIDNIFTEP-YSRFMIELT 1352

  Fly  1516 EVARKFSVLYNDSQYIVTRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFS 1580
            ::.:.:......:.|:.:|:|||||||||||||:||.|||:||:|||||:|.|..|.||::|||:
  Rat  1353 KLLKIWEPTILPNGYMFSRIEEEHLWECKQLGAYSPIVLLNTLLFFNTKYFQLKNVTEHLKLSFA 1417

  Fly  1581 HIMKHWKRSSQNSKVPGSRNVLLRFYPPQA--------GLDANPRKKKV-------YEQQENEEN 1630
            |:|:..:....::|:     ..|||:||..        .|....||:..       .|..||.:|
  Rat  1418 HVMRRTRTLKYSTKM-----TYLRFFPPPPQKQESEPDKLTIGKRKRNEDEEAPVGVEMAENTDN 1477

  Fly  1631 PLRCPVRLYEFYLSKCPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKE 1695
            ||||||||||||||||.||||.|.|||||||||||||:||:||||..:....|..||.|:.||:|
  Rat  1478 PLRCPVRLYEFYLSKCSESVKQRTDVFYLQPERSCVPNSPMWYSTFPIDPGTLDTMLTRILMVRE 1542

  Fly  1696 IN 1697
            ::
  Rat  1543 VH 1544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	TRASH	684..721	CDD:214799	3/36 (8%)
		zf-FCS	724..762	CDD:283998	18/37 (49%)
		DUF3504	1531..1690	CDD:288835	92/173 (53%)
Zmym4	XP_017448891.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2360
eggNOG	1	0.900	-	-		E1_2CMKN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I1128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266757at33208
OrthoFinder	1	1.000	-	-		FOG0004219
OrthoInspector	1	1.000	-	-		otm45004
orthoMCL	1	0.900	-	-		OOG6_103093
Panther	1	1.100	-	-	LDO	PTHR45736
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X789
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870