DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment woc and Qrich1

DIOPT Version :9

Sequence 1:	NP_001097946.1	Gene:	woc / 47249	FlyBaseID:	FBgn0010328	Length:	1703	Species:	Drosophila melanogaster
Sequence 2:	XP_006243806.1	Gene:	Qrich1 / 301004	RGDID:	1311095	Length:	777	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	243/900 - (27%)
Similarity:	372/900 - (41%)	Gaps:	260/900 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 MIYQIGGPHDQETLTCSINCL---------TMHGVSCNI--SARAVTKCDNCSNFNTPQYHLTMS 930
            |:||.||           ||:         ::..::|.:  |.:..|:.:.......||......
  Rat    53 MVYQQGG-----------NCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQV 106

  Fly   931 DA--SMRNFCTYQCVMQFQ-NQFARAPL----TLDSDLPPSSAGSSKSQQQSNRGNKNAAPFPTG 988
            ..  |.:.....|...||. :|.|..|:    .:....|.|:|.|.::....       :|.|:.
  Rat   107 QVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQ-------SPSPSQ 164

  Fly   989 LPKRVKLKLSHTGKGGVGGKKSGSGTMLP-----------VISTVQSLASGETEARIGNLTVRRK 1042
            | :..::::.|     |...:......:|           .:...||||.|:   :|...||
  Rat   165 L-QAAQIQVQH-----VQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQ---QIQIQTV--- 217

  Fly  1043 RGRPRESGTSSPPLSMPGVHPPAQRGRPRKHAVDYSARSPSPTMSGGSSHMGI-----PVRRNTT 1102
                   |..||        ||:|:|.||:                |...:|.     ||::...
  Rat   218 -------GALSP--------PPSQQGSPRE----------------GERRVGTASVLQPVKKRKV 251

  Fly  1103 TTMDFGPATVTETKIITVPPYPKAVRNVNISCKP----LTVTQGEQCS-----PDVRDCATQTEK 1158
            ..    |.||:..                ||.:|    |.:.||:|.|     ||
  Rat   252 DM----PITVSYA----------------ISGQPVATVLAIPQGQQQSYVSLRPD---------- 286

  Fly  1159 DYSNKVLIPVPVPIFVPQPMYMYSAPFPVPVPIPLPIPVPIFIPTTRNTAQGILKEIKKIQDKMP 1223
                         :......::|||...:..|......:|::....|.
  Rat   287 -------------LLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRG----------------- 321

  Fly  1224 EDPLEAELLMMAEMVAEEK----HESDSDSDNEIKPDPGLVALQYQNSLE------SVAQQQQQQ 1278
             ||.:..:..:|  :.:|.    |.|.|.:        .|.|::.::..|      ||.:...::
  Rat   322 -DPQQQSITHIA--IPQEAYNAVHVSGSPT--------ALAAVKLEDDKEKMVGTTSVVKNSHEE 375

  Fly  1279 QVVDVSGA---GHNPYGDDMLQIALKMATGDYDNHHQTSTVDLETSMTANTISSQSPMGHDGMGQ 1340
            .|..::.:   .....|:..:.:|::...|.|.|..||
  Rat   376 VVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQT--------------------------- 413

  Fly  1341 MGVHHLDQQHHMLDATQRTARGRKRGVGVVMDPPNRNSRSPVKRQRGGEMDHSALQQQSQQAQ-- 1403
              ||..|.|.   ...|:||:                .::|.:.|:..::..:...|..|.|:
  Rat   414 --VHIWDPQQ---QPQQQTAQ----------------EQTPPQPQQQQQLQVTCSAQTVQVAEVE 457

  Fly  1404 ---QPQEKPDAQM--FLKYTFGVNAWKQWVMTKNADIEKSSMRRRP---------FKTELLQMTA 1454
               |||..|:..:  .||...|:..||.|..||||::||.:..|..         |:.:|:....
  Rat   458 PQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAV 522

  Fly  1455 DELNYSLCLFVKEVRKPNGTEYAPDTIYYLVLGIQQYLYVNGRIDNIFYDPYYERFTECLDEVAR 1519
            .||||.|||..:|.|...|..|.||.:||:.|.||:||:.|||:|:||.|.||.||||.|.||.:
  Rat   523 AELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLK 587

  Fly  1520 KFSVLYNDSQYIV-TRVEEEHLWECKQLGAHSPHVLLSTLMFFNTKHFNLTTVEEHMQLSFSHIM 1583
            ..........|:: :.|.||.||||||||||||..||:||||||||:|.|.||::||:|:||.::
  Rat   588 DVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVL 652

  Fly  1584 KHWKRSSQNSKVPGSRNVLLRFYPPQAGLDANPRK--KKVY-EQQENEENPLRCPVRLYEFYLSK 1645
            :..|:|..|   |..::..:| |....|:....:|  ..:| ||.||.|||||||::||:|||.|
  Rat   653 RQTKKSPSN---PKDKSTSIR-YLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFK 713

  Fly  1646 CPESVKTRNDVFYLQPERSCVPDSPVWYSTQALGQDALQRMLHRVKMVKEINIAL 1700
            ||:|||.|||.|||.||....|:||:|||.|.:.::.:.:||.|:.:::||..|:
  Rat   714 CPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAI 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
woc	NP_001097946.1	TRASH	684..721	CDD:214799
		zf-FCS	724..762	CDD:283998
		DUF3504	1531..1690	CDD:288835	82/162 (51%)
Qrich1	XP_006243806.1	CARD	<6..48	CDD:260018
Qrich1	XP_006243806.1	DUF3504	600..760	CDD:403286	83/163 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266757at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45736
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020