DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and PCSK7

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_004707.2	Gene:	PCSK7 / 9159	HGNCID:	8748	Length:	785	Species:	Homo sapiens

Alignment Length:	708	Identity:	272/708 - (38%)
Similarity:	378/708 - (53%)	Gaps:	108/708 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 PSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPN 241
            |....|| |:..:|:..|..|..|..|...|.|  ...|.:|:.|.:.....|   .:||||:.:
Human     2 PKGRQKV-PHLDAPLGLPTCLWLELAGLFLLVP--WVMGLAGTGGPDGQGTGG---PSWAVHLES 60

  Fly   242 --GD------NGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHH----------- 285
              ||      ...|||:|:..|.||.|:|  ...||.|         :.||.|.
Human    61 LEGDGEEETLEQQADALAQAAGLVNAGRIGELQGHYLF---------VQPAGHRPALEVEAIRQQ 116

  Fly   286 -QTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLN--RGG 347
             :..|...:.|.|..:||...|:||                   ::.|||.|:||.|:||  |..
Human   117 VEAVLAGHEAVRWHSEQRLLRRAKR-------------------SVHFNDPKYPQQWHLNNRRSP 162

  Fly   348 GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNR 412
            |.|:||...|:..:||:||.|.::|||:|....||..||.|:.|||:||:|.|||||.|:.:.|.
Human   163 GRDINVTGVWERNVTGRGVTVVVVDDGVEHTIQDIAPNYSPEGSYDLNSNDPDPMPHPDVENGNH 227

  Fly   413 HGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDD 477
            ||||||||:||..||||||||:|||:.:.|:|:|||.:||::||.:.:.:.|..||||.||||||
Human   228 HGTRCAGEIAAVPNNSFCAVGVAYGSRIAGIRVLDGPLTDSMEAVAFNKHYQINDIYSCSWGPDD 292

  Fly   478 DGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEE 542
            ||||||||.:|...|...|...||.|.||||:.||||||:..||||.|||.|||:|::|.:..||
Human   293 DGKTVDGPHQLGKAALQHGVIAGRQGFGSIFVVASGNGGQHNDNCNYDGYANSIYTVTIGAVDEE 357

  Fly   543 GHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLH----HSCTVSHTGTSASAPLAAGIAALVLQS 603
            |.:|:|:|:|:|.||.|:|.|.:..:.:||||..    ..||..||||||:||||||:.||:||.
Human   358 GRMPFYAEECASMLAVTFSGGDKMLRSIVTTDWDLQKGTGCTEGHTGTSAAAPLAAGMIALMLQV 422

  Fly   604 NQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQR 668
            ...|||||:|||:|.||.....:...|..|..|...||..|:||::|..:|..|:.|.:||
Human   423 RPCLTWRDVQHIIVFTATRYEDRRAEWVTNEAGFSHSHQHGFGLLNAWRLVNAAKIWTSVP---- 483

  Fly   669 CEINAPHVDKVIP-----PRTHITLQLTVNHCR------SVNYLEHVQAKITLTSQRRGDIQLFL 722
              ..|.:|..|:.     |::..:|::..|..|      .:..||||...:::|..|||.::|.|
Human   484 --YLASYVSPVLKENKAIPQSPRSLEVLWNVSRMDLEMSGLKTLEHVAVTVSITHPRRGSLELKL 546

  Fly   723 RSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQL---EIHNEGRYMGHALLREWS 784
            ..|:.....:..||..|:..:|||.|.|.:|..|||..:|.::|   ::.:|...:|  :||:|.
Human   547 FCPSGMMSLIGAPRSMDSDPNGFNDWTFSTVRCWGERARGTYRLVIRDVGDESFQVG--ILRQWQ 609

  Fly   785 LIFYGTTQSIGP-----------------NDPISVPKPSGSE-------ATTPNSSST 818
            |..||:..|...                 :|..::|.|.|.:       ..|||:..|
Human   610 LTLYGSVWSAVDIRDRQRLLESAMSGKYLHDDFALPCPPGLKIPEEDGYTITPNTLKT 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	27/96 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	164/294 (56%)
		Peptidase_S8	363..646	CDD:278510	155/286 (54%)
		P_proprotein	701..787	CDD:279782	31/88 (35%)
		FU	1320..>1350	CDD:214589
PCSK7	NP_004707.2	S8_pro-domain	53..141	CDD:293079	27/96 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	145..440	CDD:173789	164/294 (56%)
		Peptidase_S8	196..441	CDD:278510	141/244 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..219		13/21 (62%)
		P_proprotein	525..612	CDD:279782	31/88 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750