DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and KEX2

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_014161.1	Gene:	KEX2 / 855483	SGDID:	S000005182	Length:	814	Species:	Saccharomyces cerevisiae

Alignment Length:	820	Identity:	249/820 - (30%)
Similarity:	398/820 - (48%)	Gaps:	116/820 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 DHYHFAHH--KVSKRSLSPATHHQTRLDDDDR---VHWAKQQRAKSRSKRDFIRMRPSRTSSRAM 324
            :||.|:..  |:.|||    :..:.:.|::|.   ||       ....:.|..:..|........
Yeast    66 NHYVFSKELLKLGKRS----SLEELQGDNNDHILSVH-------DLFPRNDLFKRLPVPAPPMDS 119

  Fly   325 SMV------DAMSFNDSKWPQMWYLNRGG--GLDMNVIPAWKMGITGKGVVVTILDDGLESDHPD 381
            |::      |.:|.||..:.:.|:|....  |.|:||:..|...|||.|||..|:||||:.::.|
Yeast   120 SLLPVKEAEDKLSINDPLFERQWHLVNPSFPGSDINVLDLWYNNITGAGVVAAIVDDGLDYENED 184

  Fly   382 IQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRML 446
            ::||:..:.|:|.|.:.:.|.|.  ::| :.||||||||:||...|:||.||:.|.|.:.|:|:|
Yeast   185 LKDNFCAEGSWDFNDNTNLPKPR--LSD-DYHGTRCAGEIAAKKGNNFCGVGVGYNAKISGIRIL 246

  Fly   447 DGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWA 511
            .||:|...||.||.......||||.||||.|||:.:.||.:|..:|.::|.|:||..||:|:::|
Yeast   247 SGDITTEDEAASLIYGLDVNDIYSCSWGPADDGRHLQGPSDLVKKALVKGVTEGRDSKGAIYVFA 311

  Fly   512 SGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLH 576
            |||||...||||.|||||||::::|.:...:...|.|||.||:.:|.|||| |.|| .:.::|::
Yeast   312 SGNGGTRGDNCNYDGYTNSIYSITIGAIDHKDLHPPYSEGCSAVMAVTYSS-GSGE-YIHSSDIN 374

  Fly   577 HSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTA----KPANLKDPSWSRNGVGR 637
            ..|:.||.||||:||||||:..|:|::|.||||||:|::.:.:|    |.|   |..|..:.:|:
Yeast   375 GRCSNSHGGTSAAAPLAAGVYTLLLEANPNLTWRDVQYLSILSAVGLEKNA---DGDWRDSAMGK 436

  Fly   638 RVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQ--LTVNH--CRSV 698
            :.||.:|:|.:||.:::.:::.|:.|..|....:...:|.: ....|..||:  :|::.  .:..
Yeast   437 KYSHRYGFGKIDAHKLIEMSKTWENVNAQTWFYLPTLYVSQ-STNSTEETLESVITISEKSLQDA 500

  Fly   699 NY--LEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQ 761
            |:  :|||...:.:.::.||...:.|.|||.....|...|..|.|..||..|.||||..|||:..
Yeast   501 NFKRIEHVTVTVDIDTEIRGTTTVDLISPAGIISNLGVVRPRDVSSEGFKDWTFMSVAHWGENGV 565

  Fly   762 GNWQLEIHNEGRYMGHAL-LREWSLIFYG-------TTQSIGPNDPISVPKPSGSEAT------- 811
            |:|::::.....  ||.: ...|.|..:|       |...:..||...| :|:.:|:|
Yeast   566 GDWKIKVKTTEN--GHRIDFHSWRLKLFGESIDSSKTETFVFGNDKEEV-EPAATESTVSQYSAS 627

  Fly   812 -TPNSSSTTSNLHQAYSPQYPRIPPNNFGSS-PSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPK 874
             |..|.|.||....:...:...||.....|: |......| .|:..|.::.:......|
Yeast   628 STSISISATSTSSISIGVETSAIPQTTTASTDPDSDPNTP-KKLSSPRQAMHYFLTIFL------ 685

  Fly   875 QGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQT-- 937
                 |.||:.|:......||....:..                       :.:|.:..||.|
Yeast   686 -----IGATFLVLYFMFFMKSRRRIRRS-----------------------RAETYEFDIIDTDS 722

  Fly   938 ---STSKNKYYRISQQQQQKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVVGEITTNSGNGSIKA 999
               ||..|....|::.::.::...|.:. :......:|.|....|.:   :..:.||....|
Yeast   723 EYDSTLDNGTSGITEPEEVEDFDFDLSD-EDHLASLSSSENGDAEHT---IDSVLTNENPFS--- 780

  Fly  1000 AKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSS 1039
             ..:|:.....:|:.     ....|:|.:.|::.|....|
Yeast   781 -DPIKQKFPNDANAE-----SASNKLQELQPDVPPSSGRS 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	11/48 (23%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	135/294 (46%)
		Peptidase_S8	363..646	CDD:278510	132/286 (46%)
		P_proprotein	701..787	CDD:279782	29/86 (34%)
		FU	1320..>1350	CDD:214589
KEX2	NP_014161.1	Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	133..419	CDD:173789	134/290 (46%)
KEX2	NP_014161.1	COG4935	463..653	CDD:227271	51/193 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I284
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		otm46475
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.840