DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and Tpp2

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	XP_006244914.2	Gene:	Tpp2 / 81815	RGDID:	621584	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	141/741 - (19%)
Similarity:	253/741 - (34%)	Gaps:	198/741 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PPSSALKVDPNGQSPVLPPYVLD-YETGGK------AKLTPNNGKFGQSGSSG------SNNNHI 227
            |.:..::|..:|:     |.::| .:|.|.      .::.|.:|:.  :|.||      :|..:.
  Rat    49 PGAPGMQVTTDGK-----PKIIDIIDTTGSGDVNTATEVEPKDGEI--TGLSGRVLKIPANWTNP 106

  Fly   228 VGHYTHTWAVHIPNG----DNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTR 288
            .|.| |   :.|.||    ...:.:.:.|:    ...||:|     ..|:|   :|:.|...|..
  Rat   107 SGKY-H---IGIKNGYDFYPKALKERIQKE----RKEKIWD-----PIHRV---ALAEACRKQEE 155

  Fly   289 LD--DDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSK-WPQMWYLNRGGGLD 350
            .|  ::......|..:.:.:|:.:.:.....:.|... .:.|.:.::|.: |......|..|.|.
  Rat   156 FDIANNGSSQANKLIKEELQSQVELLNSFEKKYSDPG-PVYDCLVWHDGETWRACVDSNENGDLG 219

  Fly   351 MNVI-----PAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS 410
            .:.:     .|.:.|..|...::                      :|.||.:||..:... :|..
  Rat   220 KSTVLRNYKEAQEYGSFGTAEML----------------------NYSVNIYDDGNLLSI-VTSG 261

  Fly   411 NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV--------TDAVEARSLSLNPQHID 467
            ..|||..|...|..........|:|.||.:..:::  ||.        |..:.|....:| ...|
  Rat   262 GAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKI--GDTRLSTMETGTGLIRAMIEVIN-HKCD 323

  Fly   468 IYSASWGP----DDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYT 528
            :.:.|:|.    .:.|:..    |:.:.|..:..|        |::.::||.|.......|.|.|
  Rat   324 LVNYSYGEATHWPNSGRIC----EVINEAVWKHNT--------IYVSSAGNNGPCLSTVGCPGGT 376

  Fly   529 NS--------------IWTLSISSATEEGHVPWYSE--KCSSTLATTYSSGGQGEKQVVTTDLHH 577
            .|              :...|:..........|.|.  .....|..:.|:.|.....|....|..
  Rat   377 TSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVPNWTLRG 441

  Fly   578 SCTVSHTGTSASAPLAAGIAALVLQ----SNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRR 638
              |....|||.|:|.|.|..||||.    :|.:.|...::..:..||..|:..:.....:|: .:
  Rat   442 --TQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQGHGI-IQ 503

  Fly   639 VSHSFGYGLMDAAEMVRV-----ARNWKAVPEQQRCEINAPH-----VDKVIPPRT--------H 685
            |..::.|.:.:.:...|:     ..|.:.:..:...::.||.     ::.|.|..|        .
  Rat   504 VDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENSEKISFQ 568

  Fly   686 ITLQLTVN--------HCRSVNYLEHVQAKITLTSQRRG---------DI------QLFLRSPAN 727
            :.|.||.|        |...:|...|:..::.....|.|         ||      .|| |.|.
  Rat   569 LHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLF-RVPI- 631

  Fly   728 TSVTLLTPRIHDNSRSGFNQWPFMSVH-----------------TWGE------SPQGNWQLEIH 769
              ..::..:::::|....   .|..||                 ||.|      |.:.:.:..:|
  Rat   632 --TAVIAAKVNESSHYDL---AFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVSAKFVLH 691

  Fly   770 -----NEGRYMGHALLREWSLIFYGT 790
                 .:..|..|...:..||...||
  Rat   692 AVQLVKQRAYRSHEFYKFCSLPEKGT 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	15/80 (19%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	66/326 (20%)
		Peptidase_S8	363..646	CDD:278510	63/314 (20%)
		P_proprotein	701..787	CDD:279782	22/128 (17%)
		FU	1320..>1350	CDD:214589
Tpp2	XP_006244914.2	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	100/503 (20%)
Tpp2	XP_006244914.2	TPPII	777..963	CDD:403695
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900