DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and pcsk4

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	XP_017949894.1	Gene:	pcsk4 / 779814	XenbaseID:	XB-GENE-969614	Length:	758	Species:	Xenopus tropicalis

Alignment Length:	623	Identity:	303/623 - (48%)
Similarity:	391/623 - (62%)	Gaps:	40/623 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIF--DDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            ||::|||.:|.|...: :.:||..||::||::.  .|.||..|..|.||||........||..:.
Frog    32 YTNSWAVQVPTGPKEV-ERIAKKLGFISLGQVLHGGDLYHLQHRSVQKRSLGQHRGKNIRLKKEP 95

  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWK 358
            .|||.:||....|.||.|                .|:..:...|.| ||||.....::.|:.||.
Frog    96 MVHWFEQQTINQRYKRQF----------------KAVPTDPCFWKQ-WYLNNDVKPNLGVLTAWS 143

  Fly   359 MGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAA 423
            .|.||.|||||:||||:|.||||:..||||.||||.||:|.||.|.|:.:|.|||||||||||||
Frog   144 QGYTGAGVVVTVLDDGIEKDHPDLSANYDPMASYDFNSNDPDPQPRYNPSDENRHGTRCAGEVAA 208

  Fly   424 TANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGEL 488
            .|.|:.|..|||:.:.:||:|||||.:||.:||:|||||||||.||||||||:||||.|||||.|
Frog   209 AAYNNICGAGIAFNSKIGGIRMLDGLITDVIEAQSLSLNPQHIHIYSASWGPEDDGKRVDGPGPL 273

  Fly   489 ASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCS 553
            |..||..|...||||.||||:|||||||.:.||||||||||||:|||:.|.||.|:||||||.|:
Frog   274 AEEAFFWGAVNGRGGLGSIFVWASGNGGLQYDNCNCDGYTNSIYTLSVGSTTEHGNVPWYSEACA 338

  Fly   554 STLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVR 618
            |||.||:|||...|::::|||:...||..|:||||||||||||.||.|::|..||||||||||||
Frog   339 STLTTTFSSGISTERKILTTDIRLRCTDQHSGTSASAPLAAGIIALALEANPALTWRDLQHIVVR 403

  Fly   619 TAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPR 683
            .:.|:||....|:.|||||:|||.:||||:||..:|.:|:.|:....|:.|.:......:|: ..
Frog   404 ASNPSNLSAEDWAVNGVGRKVSHYYGYGLLDAGRIVDLAQKWQTAGVQRICVVKVLTTPQVL-TS 467

  Fly   684 THITLQLTVNHCRS----VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSG 744
            .||..| .|:.|..    :..||||||||:|:..||||:::.|.||..|...|:..|.:|.|..|
Frog   468 NHIVRQ-HVDGCTGTSSYIQSLEHVQAKISLSYSRRGDLEISLISPMGTRSVLVALRPYDTSTKG 531

  Fly   745 FNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGP--------NDPIS 801
            :..|.|||.|||.|.|||.|.|::.|:|.:.....|.:::|:.|||.:.:..        :|.::
Frog   532 YKNWTFMSTHTWDEKPQGTWTLKLVNKGDFTNTGFLHDFTLVLYGTDEDMMGRRLEHAVLSDCVT 596

  Fly   802 VPKPSGSEATTPNSSSTTSNLHQAYSP-----QYPRIP 834
            ..| ||......:|.....||..:|.|     .:.:||
Frog   597 RDK-SGKCHECKSSFYAFGNLCLSYCPPKFFKTFKKIP 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	28/76 (37%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	187/288 (65%)
		Peptidase_S8	363..646	CDD:278510	189/282 (67%)
		P_proprotein	701..787	CDD:279782	39/85 (46%)
		FU	1320..>1350	CDD:214589
pcsk4	XP_017949894.1	S8_pro-domain	35..111	CDD:374560	28/76 (37%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	117..405	CDD:173789	187/288 (65%)
		P_proprotein	488..574	CDD:366670	39/85 (46%)
		FU	647..>677	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I499
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42884
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110