DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur1 and pcsk5a

DIOPT Version :9

Sequence 1:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster
Sequence 2:XP_003198725.3 Gene:pcsk5a / 571235 ZFINID:ZDB-GENE-060531-130 Length:1867 Species:Danio rerio


Alignment Length:1321 Identity:423/1321 - (32%)
Similarity:561/1321 - (42%) Gaps:341/1321 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            ||:.|||.|..|... ||.:|:.:||||:|:|  ..|||.|.|..:.|||...:..:.:.:..:.
Zfish    25 YTNRWAVKITGGPEA-ADLIAEKYGFVNMGQIGGLVDHYQFQHSGIIKRSTIKSKGNHSLITMET 88

  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGG--LDMNVIPA 356
            :|.|.:||..:.|.||           :..|......||||.||..|||::....  .|||:..|
Zfish    89 KVEWIQQQMVQKRVKR-----------TETMDQTHDGSFNDPKWDSMWYIHCDHNCLTDMNIQAA 142

  Fly   357 WKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEV 421
            |:.|.|||||||:|||||:|..|||::.|||.:||||||.:|.||.|.||:|:.|:|||||||.|
Zfish   143 WRRGYTGKGVVVSILDDGIERQHPDLKQNYDARASYDVNGNDPDPTPRYDVTNENKHGTRCAGVV 207

  Fly   422 AATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPG 486
            ||:||||.|.|||||.|.:|||||||||:||.|||:||:|..|:|||||:||||||||:||||||
Zfish   208 AASANNSLCIVGIAYNAKIGGVRMLDGDMTDMVEAQSLNLRQQYIDIYSSSWGPDDDGRTVDGPG 272

  Fly   487 ELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEK 551
            .||..|...|..|||.|:||||:|||||||:.||:|:||||||||:|:|:.|.|:.|..|||.|:
Zfish   273 PLARLALENGIRKGRKGRGSIFVWASGNGGQSQDHCSCDGYTNSIYTISVGSTTQSGRKPWYLEE 337

  Fly   552 CSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIV 616
            ||||||||||||......||||||...||..|:|||||||:||||.||.|::|..|||||:|||:
Zfish   338 CSSTLATTYSSGDSHSPGVVTTDLRQRCTDEHSGTSASAPMAAGIIALTLEANPALTWRDIQHII 402

  Fly   617 VRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIP 681
            |:|:...:|....|..||.|..|||.:|:||::|..||:.|..||.||.|..||.|.....::|.
Zfish   403 VKTSSRGHLSASDWQSNGAGYDVSHLYGFGLLNAEAMVKNAETWKQVPSQHICEENIGQNARIIS 467

  Fly   682 PRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNS 741
            |...:...|..:.|     :.|.|||||..::|:|...|||:.:.|.||:.|:..||..|.:|:|
Zfish   468 PERVLRSVLKSSGCSAQRLQRVVYLEHVIVRVTITHPHRGDLSITLTSPSGTTSQLLANRPNDHS 532

  Fly   742 RSGFNQWPFMSVHTWGESPQGNWQLEIHN------EGRYMGHALLREWSLIFYGTTQS--IGPND 798
            ..||.:|.||:.|.|||...|:|.|:|.:      ..|..|.  |.||||:.|||:..  |....
Zfish   533 SEGFIKWEFMTTHCWGERSAGDWILDIRDTPSPQRNTRLQGK--LVEWSLVLYGTSTHPYIRHEQ 595

  Fly   799 PISVPKPS-------------------GSEATTPNSSSTTSNLHQAYSPQYPRIPPNN----FGS 840
            |.|...||                   |.|...|:...:..||...:.        ||    ...
Zfish   596 PRSAQLPSEDEITEEYNGSCDPECSEDGCEGPGPHQCVSCLNLFLKFK--------NNTRTCVSE 652

  Fly   841 SPSG--GSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNN--NSKE 901
            .|||  |.|....|.....||...:.:....:.  |.||.            .|.:.||  .|.|
Zfish   653 CPSGYWGDKKRCKKCYSSCKSCLGSRSDQCTTC--KSGYH------------LNEEKNNCVTSCE 703

  Fly   902 ------KTNNKGNKSNNGNKGK----------SGGSS--GNRKEQTTQSTIIQTSTSKNKYYRIS 948
                  ...|...|.|..|..|          |.|:|  |||         .|.|.....||   
Zfish   704 DGYFLYHEENMCRKCNIENCMKCTSASICTECSEGTSLVGNR---------CQKSCEVGSYY--- 756

  Fly   949 QQQQQKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNS 1013
                                       |..|.|.:.............:::..:..|.       
Zfish   757 ---------------------------SEPEDSCEACHPACATCAAAGLESCNRCAEG------- 787

  Fly  1014 RIPKLFERYEKI----QAIFPELEPYENSS---------------PKGKPKQAKQGKQFE--VDL 1057
               .|.|.:..:    |..:.|.:..:|.|               .|....:...|...:  |.:
Zfish   788 ---YLMENWRCVSSCSQGFYAEQQNSDNQSTCKRCDASCLACVGPTKTNCSECVDGHSLQDGVCV 849

  Fly  1058 FKPTNGGNSRQGNTKKSPSV--------PPPSQTMATLSILPIL--------------PAGGSSF 1100
            .....|....|..:.:..|.        .|.|:...:.....:|              |:||...
Zfish   850 LSHNCGDGEYQDESGECQSCHVSCQKCKGPQSEDCLSCFSTHLLDYGQCVISCSNGKYPSGGQCH 914

  Fly  1101 LPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEARKDQRKEVNGPNAQITQWD------ 1159
            |.|...                ||. |:                    :|| :..|..|      
Zfish   915 LCDHTC----------------AQC-VD--------------------DGP-SNCTSCDTDKFGV 941

  Fly  1160 --MIFYGTETPAQPD-------DVANPSQSN-------------QFNLYGNDMAHN--------- 1193
              .:::|....|.|.       ....|..|.             :.:.|.|:...|         
Zfish   942 DRYLYHGECVDACPKAHFHTVLKACEPCPSYCKLCSSATHCIKCEDSFYVNNGVCNKLECGEGEV 1006

  Fly  1194 -DVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCYDVCPVHTYPL 1257
             |.|||..       ...|.|..:       |:.::.:.||.|.:..|.||:.||..||..|||:
Zfish  1007 EDPEYDDC-------MPCEEGCHK-------CVLYNPKHCLSCINGYYRFEESCYKNCPSKTYPV 1057

  Fly  1258 -----------DKFQAEEDE------------------------------------QDDEVTRGP 1275
                       |....:|||                                    .|.....||
Zfish  1058 EETMSCVSCEHDCVNCDEDECSWCEADFFISNGKCVRECPDGFYNDNESQECEECHSDCRTCSGP 1122

  Fly  1276 VNPYSSSPMDHSLLMSNSLDDKQDPLQAEDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQ 1340
            .:....|..:...|.:.:...:||...|          |:.......|.||...|..|:|.:.:|
Zfish  1123 EDSDCESCSEGLTLDNGACVSEQDVCPA----------QMYLTDDGECEACHPLCESCWGKMKNQ 1177

  Fly  1341 CSTCSPGSQLRKILNETFCYA 1361
            |:||..|    :.||...|.|
Zfish  1178 CNTCVKG----RYLNADQCVA 1194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:293079 27/76 (36%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 332..621 CDD:173789 190/290 (66%)
Peptidase_S8 363..646 CDD:278510 184/282 (65%)
P_proprotein 701..787 CDD:279782 38/91 (42%)
FU 1320..>1350 CDD:214589 11/29 (38%)
pcsk5aXP_003198725.3 S8_pro-domain 29..104 CDD:318632 27/75 (36%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-lik 116..406 CDD:173789 189/289 (65%)
P_proprotein 492..582 CDD:307572 38/91 (42%)
FU 615..726 CDD:320742 27/132 (20%)
VSP 682..1073 CDD:333463 83/505 (16%)
VSP 1019..>1277 CDD:333463 43/197 (22%)
Furin-like_2 1274..1341 CDD:318185
FU 1402..1448 CDD:238021
FU 1453..1565 CDD:320742
FU 1550..1599 CDD:238021
FU 1596..1639 CDD:214589
FU 1649..1686 CDD:214589
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311719at33208
OrthoFinder 1 1.000 - - FOG0000204
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100362
Panther 1 1.100 - - O PTHR42884
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.820

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