DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and Mbtps1

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001161382.1	Gene:	Mbtps1 / 56453	MGIID:	1927235	Length:	1052	Species:	Mus musculus

Alignment Length:	657	Identity:	123/657 - (18%)
Similarity:	208/657 - (31%)	Gaps:	233/657 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 RMRPSRTSSRAMSMVDA---MSFNDSKWPQMWYLNR---------GGGL-----------DMNVI 354
            |:.|.|...|::...::   :..|:::|.|.|..:|         |.|.           .:..|
Mouse   125 RVTPQRKVFRSLKFAESNPIVPCNETRWSQKWQSSRPLKRASLSLGSGFWHATGRHSSRRLLRAI 189

  Fly   355 P-----------AWKMGITGKGVVVTILDDGLESDHPDIQD-----NYDPKASYDVNSHDDDPMP 403
            |           .|:||.||..|.|.:.|.||...||..::     |:..:.:.|
Mouse   190 PRQVAQTLQADVLWQMGYTGANVRVAVFDTGLSEKHPHFKNVKERTNWTNERTLD---------- 244

  Fly   404 HYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGD-------VTDAVEARSLSL 461
                 |...|||..||.:|:...   |. |.|..|.:...|:...:       ..||.....|
Mouse   245 -----DGLGHGTFVAGVIASMRE---CQ-GFAPDAELHIFRVFTNNQVSYTSWFLDAFNYAIL-- 298

  Fly   462 NPQHIDIYSASWGPDD--DGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNC 524
              :.:|:.:.|.|..|  |...||...||.:             ...|.:.|.||.|......|
Mouse   299 --KKMDVLNLSIGGPDFMDHPFVDKVWELTA-------------NNVIMVSAIGNDGPLYGTLN- 347

  Fly   525 DGYTNSIWTLSISSATEEGHVPWYSEKCSSTL------------ATTYSSGGQGEKQVVTTDLHH 577
             ...:.:..:.:.....|.::..:|.:..:|.            ..||.:|.:|      :.:..
Mouse   348 -NPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRVKPDIVTYGAGVRG------SGVKG 405

  Fly   578 SCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDP--SWSRNGVGRRVS 640
            .|. :.:|||.::|:.||...|::.:.|.   |:|       ..||::|..  :.:|...|..:.
Mouse   406 GCR-ALSGTSVASPVVAGAVTLLVSTVQK---REL-------VNPASVKQALIASARRLPGVNMF 459

  Fly   641 HSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQ 705
            .. |:|.:|.....::..::|     .:..::..::|....|       ....:|....|
Mouse   460 EQ-GHGKLDLLRAYQILSSYK-----PQASLSPSYIDLTECP-------YMWPYCSQPIY----- 506

  Fly   706 AKITLTSQRRGDIQLFLRSPANTSVTLLT------------------PRIHDNSRSGFNQ----W 748
                           :...|...:||:|.                  |:..||....|:.    |
Mouse   507 ---------------YGGMPTIVNVTILNGMGVTGRIVDKPEWRPYLPQNGDNIEVAFSYSSVLW 556

  Fly   749 P---FMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEA 810
            |   ::::.........:|      ||...||.::         |..|     |......||:|.
Mouse   557 PWSGYLAISISVTKKAASW------EGIAQGHIMI---------TVAS-----PAETELHSGAEH 601

  Fly   811 T-------------TPNSSSTTSNLHQAYSPQYP--RIPPNNFGSSPSGGSKLPLGKVPPPNKSS 860
            |             ||..|.      :....||.  |.||..|                 |..:.
Mouse   602 TSTVKLPIKVKIIPTPPRSK------RVLWDQYHNLRYPPGYF-----------------PRDNL 643

  Fly   861 YVTNNPL 867
            .:.|:||
Mouse   644 RMKNDPL 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	71/345 (21%)
		Peptidase_S8	363..646	CDD:278510	64/310 (21%)
		P_proprotein	701..787	CDD:279782	15/110 (14%)
		FU	1320..>1350	CDD:214589
Mbtps1	NP_001161382.1	Peptidases_S8_SKI-1_like	203..455	CDD:173805	66/306 (22%)
		DUF4350	651..724	CDD:379527	123/657 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..900
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1026..1052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900