DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and fras1

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	XP_005165392.1	Gene:	fras1 / 563428	ZFINID:	ZDB-GENE-060526-68	Length:	4003	Species:	Danio rerio

Alignment Length:	665	Identity:	128/665 - (19%)
Similarity:	206/665 - (30%)	Gaps:	209/665 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   827 SPQ--YP-----RIPPNN-----FGSSPS---------------GGSKLPL-----GKV------ 853
            :||  :|     |||||.     |..||.               ..||..:     |||
Zfish    63 NPQCDFPRGERLRIPPNKCCPECFAPSPGICHHEGLVYGHDSQWSNSKCSVCTCAHGKVTCGPRA 127

  Fly   854 -PP----PNKSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNG 913
             ||    .::|.::.:    .:..|...:..:|.::       .|:...:..|.|::...|....
Zfish   128 CPPLSCGKDQSPFIPD----GNCCPVCAHNGVSCSW-------EGREYRDGLEWTSSPCTKCRCR 181

  Fly   914 NKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQ--QQQQKN-----NKQDRNGVQTQRPKAN 971
            |        |:.:....:...:....::|......|  .|.:.|     ..:.::|.|.||....
Zfish   182 N--------GHTECLVAECQPVTCKVNENLVVHPGQCCPQCEPNPCMEAGNEYKHGEQWQRSSCT 238

  Fly   972 S--GEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERY------------ 1022
            :  .::.:.....:....:..:.|...:|.|.|..|...||..|.:.:...||
Zfish   239 TCVCDRGHSRCQTEKCPPLHCDKGQTKVKRADQCCEDCATSKGSCLYEGIVRYHGDMWNGTGCEF 303

  Fly  1023 ---EKIQAIFPELEPYENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPSVPPPSQTM 1084
               |:.|.:...:|...:..|:|:......||... :....|:.....|.:.|...::    ::.
Zfish   304 CMCERGQVLCQRVECSRSECPRGEKLVHLPGKCCP-ECKTTTSSCTYSQPDQKGQKAI----KSF 363

  Fly  1085 ATLSILPILPAG------------------------GSSFLPDQKILKKQQLLMAAAGVMAPAQV 1125
            ..||.|.|:..|                        |:..:|.::            ........
Zfish   364 RRLSNLEIVREGLCRECQCQEGHVTCYQHSCPTCPLGTLTIPHRE------------QCCPDCNP 416

  Fly  1126 EVEMEE----VHATPDY--EARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFN 1184
            ||:..|    ...|||:  ..|......:||...|.........|....|     ..||.:.
Zfish   417 EVKCHEDCLTCSGTPDHCASCRDPSALLMNGRCLQACPQGFFAQGKVCAA-----CQPSCAT--- 473

  Fly  1185 LYGNDMAHNDVEYDSTG-----QWRNMQQVGEVGMTRDHSNTAACLKWSD----------RKCLE 1234
                  ..||.|..:.|     ..|......|.|:.:.|::   ||...|          :.||.
Zfish   474 ------CENDFECTACGGSFLLSGRQCVATCERGLFQAHTH---CLSCHDLCSSCQGAGPQDCLT 529

  Fly  1235 CNDSAYMFED-QCYDVC-------PVHTYPLDKFQAEEDEQDDEVTRGPVNP-YSSSPMDHSLLM 1290
            |:||:::.:| .|...|       ..:.|..|...|         |..|.:| ..|.|.:|:|..
Zfish   530 CSDSSHLLKDGYCVSDCGPGFYTSQGNCYACDPSCA---------TCQPDSPSCMSCPAEHALHQ 585

  Fly  1291 SNSLDDKQDPLQ--AEDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKI 1353
            ....  .|.|.|  .:|..|              |.||..||..|.|...|.|::||..    .|
Zfish   586 GKCA--PQCPAQYYKDDHGR--------------CQACHSSCASCSGPAVSHCTSCSKA----LI 630

  Fly  1354 LNETFCYAYVVRSTG 1368
            ||:..|    |.|.|
Zfish   631 LNQGQC----VESCG 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789
		Peptidase_S8	363..646	CDD:278510
		P_proprotein	701..787	CDD:279782
		FU	1320..>1350	CDD:214589	11/29 (38%)
fras1	XP_005165392.1	VWC	26..85	CDD:278520	8/21 (38%)
		VWC	93..150	CDD:278520	9/60 (15%)
		VWC	157..214	CDD:278520	8/71 (11%)
		VWC	219..276	CDD:278520	9/56 (16%)
		VWC	283..340	CDD:278520	9/57 (16%)
		VWC	364..414	CDD:302663	7/61 (11%)
		FU	419..465	CDD:238021	9/45 (20%)
		Furin-like_2	424..512	CDD:292535	21/104 (20%)
		FU	461..503	CDD:214589	11/55 (20%)
		FU	507..551	CDD:214589	11/46 (24%)
		GF_recep_IV	512..669	CDD:291509	42/163 (26%)
		FU	555..597	CDD:214589	13/52 (25%)
		Furin-like	588..762	CDD:279142	23/78 (29%)
		FU	602..645	CDD:214589	19/62 (31%)
		FU	648..700	CDD:214589
		FU	704..748	CDD:214589
		Furin-like	737..911	CDD:279142
		FU	754..796	CDD:214589
		FU	855..897	CDD:214589
		Furin-like	888..1054	CDD:279142
		FU	950..994	CDD:214589
		FU	1044..1086	CDD:214589
		Cadherin_3	<1097..1196	CDD:292802
		Cadherin_3	1166..1306	CDD:292802
		Cadherin_3	1406..1538	CDD:292802
		Cadherin_3	1526..1689	CDD:292802
		Cadherin_3	1658..1811	CDD:292802
		Cadherin_3	1777..1934	CDD:292802
		Cadherin_3	1901..2056	CDD:292802
		Cadherin_3	2025..2175	CDD:292802
		Cadherin_3	2144..2290	CDD:292802
		Cadherin_3	2258..2403	CDD:292802
		Cadherin_3	2372..2534	CDD:292802
		Calx-beta	2550..2647	CDD:295344
		Calx-beta	2672..2771	CDD:295344
		Calx-beta	2795..2891	CDD:295344
		Calx-beta	2917..3008	CDD:295344
		Calx-beta	3036..3130	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810