DRSC/TRiP Functional Genomics Resources

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Protein Alignment Fur1 and PCSK4

DIOPT Version :9

Sequence 1:NP_001262954.1 Gene:Fur1 / 47220 FlyBaseID:FBgn0004509 Length:1478 Species:Drosophila melanogaster
Sequence 2:XP_011526387.1 Gene:PCSK4 / 54760 HGNCID:8746 Length:782 Species:Homo sapiens


Alignment Length:682 Identity:312/682 - (45%)
Similarity:404/682 - (59%) Gaps:84/682 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDD--HYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            |..:|||.:..| |...:.:|:..||||||.||.|  ::|..|..|.::||:|...|:..|..:.
Human    34 YVSSWAVQVSQG-NREVERLARKFGFVNLGPIFPDGQYFHLRHRGVVQQSLTPHWGHRLHLKKNP 97

  Fly   294 R---------------------------VHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMS 331
            :                           |.|.:||..:.|.||..:  .|:              
Human    98 KTRPGPKSIQQEEAGRPRYGNHGACQGLVQWFQQQTLQRRVKRSVV--VPT-------------- 146

  Fly   332 FNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNS 396
              |..:.:.||:|.....|::::.||..|::|:|:||::||||:|.||||:..||||.||||.|.
Human   147 --DPWFSKQWYMNSEAQPDLSILQAWSQGLSGQGIVVSVLDDGIEKDHPDLWANYDPLASYDFND 209

  Fly   397 HDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSL 461
            :|.||.|.|..:..|||||||||||||.|||.||.||:|:.|.:||||||||.:||.:||:||||
Human   210 YDPDPQPRYTPSKENRHGTRCAGEVAAMANNGFCGVGVAFNARIGGVRMLDGTITDVIEAQSLSL 274

  Fly   462 NPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDG 526
            .||||.||||||||:|||:||||||.|...||..|.||||||.|::|||||||||...|||||||
Human   275 QPQHIHIYSASWGPEDDGRTVDGPGILTREAFRRGVTKGRGGLGTLFIWASGNGGLHYDNCNCDG 339

  Fly   527 YTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAP 591
            |||||.|||:.|.|::|.||||||.|:|||.||||||...:.|:|||||||.||..|||||||||
Human   340 YTNSIHTLSVGSTTQQGRVPWYSEACASTLTTTYSSGVATDPQIVTTDLHHGCTDQHTGTSASAP 404

  Fly   592 LAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRV 656
            ||||:.||.|::|..|||||:||:|||.:|||:|:...|..|||||:|||.:||||:||..:|..
Human   405 LAAGMIALALEANPFLTWRDMQHLVVRASKPAHLQAEDWRTNGVGRQVSHHYGYGLLDAGLLVDT 469

  Fly   657 ARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHC----RSVNYLEHVQAKITLTSQRRGD 717
            ||.|.....|::|.:........|.|..:|  :..|:.|    .|:..||||||::||:..||||
Human   470 ARTWLPTQPQRKCAVRVQSRPTPILPLIYI--RENVSACAGLHNSIRSLEHVQAQLTLSYSRRGD 532

  Fly   718 IQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLRE 782
            :::.|.||..|..||:..|..|.|..|:|.|.|||.|.|.|:|||.|.|.:.|:|.|.....|..
Human   533 LEISLTSPMGTRSTLVAIRPLDVSTEGYNNWVFMSTHFWDENPQGVWTLGLENKGYYFNTGTLYR 597

  Fly   783 WSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSS----TTSNLHQAY-SPQYPRIPPNNFGSSP 842
            ::|:.|||.:.:       ..:|:|.:.|   ||:    .|..|.||. .|.|..          
Human   598 YTLLLYGTAEDM-------TARPTGPQVT---SSACVQRDTEGLCQACDGPAYIL---------- 642

  Fly   843 SGGSKLPLGKVPPP--NKSSYVTNNPLLNSAP 872
               .:|.|...||.  |.:..||..|...:||
Human   643 ---GQLCLAYCPPRFFNHTRLVTAGPGHTAAP 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fur1NP_001262954.1 S8_pro-domain 234..309 CDD:293079 28/103 (27%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 332..621 CDD:173789 185/288 (64%)
Peptidase_S8 363..646 CDD:278510 191/282 (68%)
P_proprotein 701..787 CDD:279782 40/85 (47%)
FU 1320..>1350 CDD:214589
PCSK4XP_011526387.1 S8_pro-domain 37..140 CDD:293079 28/103 (27%)
Peptidases_S8_Protein_convertases_Kexins_Fur in-like 145..434 CDD:173789 186/304 (61%)
Peptidase_S8 176..459 CDD:278510 191/282 (68%)
P_proprotein 516..602 CDD:279782 40/85 (47%)
FU 674..711 CDD:214589
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 449 1.000 Domainoid score I515
eggNOG 1 0.900 - - E1_COG1404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D311719at33208
OrthoFinder 1 1.000 - - FOG0000204
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100362
Panther 1 1.100 - - O PTHR42884
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2431
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.780

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