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Protein Alignment Fur1 and Furin

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_062204.2	Gene:	Furin / 54281	RGDID:	3274	Length:	793	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	347/644 - (53%)
Similarity:	425/644 - (65%)	Gaps:	51/644 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRV 295
            :|:|||||| :|...:||:||:.|||.|||:||.|:|||.|..|:||||||.....:||..:.:|
  Rat    30 FTNTWAVHI-SGGPAVADSVARKHGFHNLGQIFGDYYHFWHRAVTKRSLSPHRPRHSRLQREPQV 93

  Fly   296 HWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMG 360
            .|.:||.||.|:||| :...|:                |.|:||.|||:.....|:||..||..|
  Rat    94 KWLEQQVAKQRAKRD-VYQEPT----------------DPKFPQQWYLSGVTQRDLNVKEAWAQG 141

  Fly   361 ITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATA 425
            .||:|:||:|||||:|.:|||:..||||.||:|||..|.||.|.|...:.|||||||||||||.|
  Rat   142 FTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVA 206

  Fly   426 NNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELAS 490
            ||..|.||:||.|.:||||||||:||||||||||.|||.||.||||||||:|||||||||..||.
  Rat   207 NNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAE 271

  Fly   491 RAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSST 555
            .||..|.::||||.||||:|||||||||.|:||||||||||:||||||||:.|:||||||.||||
  Rat   272 EAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSST 336

  Fly   556 LATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTA 620
            ||||||||.|.|||:|||||...||.|||||||||||||||.||.|::|:||||||:||:||:|:
  Rat   337 LATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTS 401

  Fly   621 KPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTH 685
            |||:|....|:.|||||:||||:||||:||..||.:|:||..|..|::|.|......|.|..|..
  Rat   402 KPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIEILAEPKDIGKRLE 466

  Fly   686 ITLQLTV-----NHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGF 745
            :...:|.     ||   ::.||||||::||:..||||:.:.|.||..|..|||..|.||.|..||
  Rat   467 VRKTVTACLGEPNH---ISRLEHVQARLTLSYNRRGDLAIHLISPMGTRSTLLAARPHDYSADGF 528

  Fly   746 NQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEA 810
            |.|.||:.|:|.|.|.|.|.|||.|......:..|.:::|:.|||. |.|.:.|   |:.||.:.
  Rat   529 NDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA-SEGLSAP---PESSGCKT 589

  Fly   811 TTPNSSSTTS----NLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNN 865
            .|.:.:....    :|||....|  |.||               |..|....:.|.|.|
  Rat   590 LTSSQACVVCEEGFSLHQKSCVQ--RCPP---------------GFTPQVLDTHYSTEN 631

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.