DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and PCSK2

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_002585.2	Gene:	PCSK2 / 5126	HGNCID:	8744	Length:	638	Species:	Homo sapiens

Alignment Length:	580	Identity:	271/580 - (46%)
Similarity:	369/580 - (63%)	Gaps:	35/580 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGF-VNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDR 294
            :|:.:.|.:..|....|..||.:||| |......:..|||.|:.::|.....:.||:.:|:.|.|
Human    30 FTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPR 94

  Fly   295 VHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGG------GLDMNV 353
            |..|.||....|.||.:          |.::.:| ::.||..:.:.|||...|      |||:||
Human    95 VKMALQQEGFDRKKRGY----------RDINEID-INMNDPLFTKQWYLINTGQADGTPGLDLNV 148

  Fly   354 IPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS--NRHGTR 416
            ..||::|.|||||.:.|:|||::..|||:..||:.:||||.:|:|..|.|.|  ||.  |.||||
Human   149 AEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRY--TDDWFNSHGTR 211

  Fly   417 CAGEVAATANNSFCAVGIAYGASVGGVRMLDGD-VTDAVEARSLSLNPQHIDIYSASWGPDDDGK 480
            |||||:|.|||:.|.||:||.:.|.|:||||.. :||.:||.|:|..||.||||||||||.|:||
Human   212 CAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGK 276

  Fly   481 TVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHV 545
            |||||.||..:|..:|..|||||||||::||||:|| ..|:||||||.:|:||:||:||..:|..
Human   277 TVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNCDGYASSMWTISINSAINDGRT 340

  Fly   546 PWYSEKCSSTLATTYSSGGQ--GEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLT 608
            ..|.|.||||||:|:|:|.:  .|..|.||||:.:||:.|:||||:||.|||:.||.|::|..||
Human   341 ALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLT 405

  Fly   609 WRDLQHIVVRTAKPANLKDP--SWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEI 671
            |||:||:.|.|:|...|.|.  .|.|||||...:|.||||::||..||::|::||.|||:..|..
Human   406 WRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVG 470

  Fly   672 NAPHVDKVIPPRTHITLQLTVNHCRS----VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTL 732
            .:....:.||....:.|.||.:.|..    |.|||||||.||:.:.||||:.:.:.||..|...|
Human   471 GSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 535

  Fly   733 LT--PRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGT 790
            |:  || .|:|:.||::||||:.|||||..:|.|.||:...|......:|:||:|:.:||
Human   536 LSRRPR-DDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGT 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	24/75 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	166/299 (56%)
		Peptidase_S8	363..646	CDD:278510	163/289 (56%)
		P_proprotein	701..787	CDD:279782	41/87 (47%)
		FU	1320..>1350	CDD:214589
PCSK2	NP_002585.2	S8_pro-domain	33..109	CDD:293079	24/75 (32%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	122..418	CDD:173789	166/298 (56%)
		Peptidase_S8	158..435	CDD:278510	158/279 (57%)
		P_proprotein	504..591	CDD:279782	41/87 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850