DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and PCSK5

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001358972.1	Gene:	PCSK5 / 5125	HGNCID:	8747	Length:	1887	Species:	Homo sapiens

Alignment Length:	1282	Identity:	412/1282 - (32%)
Similarity:	558/1282 - (43%)	Gaps:	323/1282 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSL--SPATHHQTRLDD 291
            ||:.|||.|..| ...|:.:|..:||:|:|:|  ..|:|||.|.:..|||:  |..||  :.:..
Human    35 YTNHWAVKIAGG-FPEANRIASKYGFINIGQIGALKDYYHFYHSRTIKRSVISSRGTH--SFISM 96

  Fly   292 DDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGL-----DM 351
            :.:|.|.:||..|.|:|||:       ..|||.|..    |||.|||.|||::.....     ||
Human    97 EPKVEWIQQQVVKKRTKRDY-------DFSRAQSTY----FNDPKWPSMWYMHCSDNTHPCQSDM 150

  Fly   352 NVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTR 416
            |:..|||.|.|||.:||||||||:|..|||:..|||..||.|||.:|.||||.||.::.|:||||
Human   151 NIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTR 215

  Fly   417 CAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKT 481
            |||||||.||||.|.||||:.|.:||||||||||||.|||:|:|.||||:.||||||||||||||
Human   216 CAGEVAAAANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSFNPQHVHIYSASWGPDDDGKT 280

  Fly   482 VDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVP 546
            ||||..|..:||..|...||.|.||:|:||||||||.:|:|:||||||||:|:||||..|.|..|
Human   281 VDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKP 345

  Fly   547 WYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRD 611
            ||.|:||||||||||||...:|:::||||...||.:|||||||||:||||.||.|::|..|||||
Human   346 WYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRD 410

  Fly   612 LQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHV 676
            :||::|||::..:|....|..|..|.:|||.:|:|||||..||..|..|..||.|..|..:....
Human   411 VQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPRQHVCVESTDRQ 475

  Fly   677 DKVIPPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPR 736
            .|.|.|.:.:......:.|     |.|||||||..:||:|..||||:.::|.||:.|...||..|
Human   476 IKTIRPNSAVRSIYKASGCSDNPNRHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 540

  Fly   737 IHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGH----ALLREWSLIFYGTTQSIGPN 797
            :.|:|..||..|.||::|.|||...|:|.||:::....:.:    ..|:||||:.|||  |:.|.
Human   541 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGT--SVQPY 603

  Fly   798 DPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRI--PPNNFGSSPSGGSKLP-LGKV----PP 855
            .|                   |:...:....:|.|:  |.:::|:....|...| ..:|    |.
Human   604 SP-------------------TNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPG 649

  Fly   856 PNKSS-------YVTNNP--LLNSAPP----------------------KQGYQQISATYGVILG 889
            |:..:       .:.||.  .::|.||                      ..|.|.:|..||..|
Human   650 PDHCNDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFL- 713

  Fly   890 KANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQ---- 950
                      .|:||:......:|:                     ...|.||...:.|:.
Human   714 ----------NEETNSCVTHCPDGS---------------------YQDTKKNLCRKCSENCKTC 747

  Fly   951 QQQKNNKQDRNGVQTQRPKA----------------------------------NSGEKSYDEKS 981
            .:..|..:.|:|:..|..:.                                  |..|..:.|..
Human   748 TEFHNCTECRDGLSLQGSRCSVSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDG 812

  Fly   982 RKV----VGEITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYEN--SSP 1040
            |.|    :.....:|.....|:.|:...|..|.:.                    ..::|  |.|
Human   813 RCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNG--------------------PGFKNCTSCP 857

  Fly  1041 KGKPKQAKQGKQFEVDLFKPTNGGNSRQG------------NTKKSPSVPPPSQTMATLSILPIL 1093
            .|          :.:||.....|...:.|            ....:....|..:...|..:..|.
Human   858 SG----------YLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIF 912

  Fly  1094 PAGGS-SFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEARKDQRKEVNGPNAQITQ 1157
            ..|.. |..|..|.                 :.|.:....|.|       .||.:.:|| ...|.
Human   913 DDGRCVSNCPSWKF-----------------EFENQCHPCHHT-------CQRCQGSGP-THCTS 952

  Fly  1158 WDMIFYGTETPAQPDDVANPSQSNQFNLYGN---------DMAHN-------------------- 1193
            .....||.|......:..:......:...||         ::.|:
Human   953 CGADNYGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTC 1017

  Fly  1194 -----------DVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCY 1247
                       |.:|:.....    :.|.:|.:.|...|          |..|....|.|:..||
Human  1018 QKLECGQGEVQDPDYEECVPC----EEGCLGCSLDDPGT----------CTSCAMGYYRFDHHCY 1068

  Fly  1248 DVCPVHTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHS---------LLMSNSLDDKQDPLQA 1303
            ..||..||            .:||.....:....| .|.:         .|:..|...|..|...
Human  1069 KTCPEKTY------------SEEVECKACDSNCGS-CDQNGCYWCEEGFFLLGGSCVRKCGPGFY 1120

  Fly  1304 EDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQL 1350
            .|:....            |.:|.|:|..|.|....:||:|..|.||
Human  1121 GDQEMGE------------CESCHRACETCTGPGHDECSSCQEGLQL 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	29/78 (37%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	192/293 (66%)
		Peptidase_S8	363..646	CDD:278510	183/282 (65%)
		P_proprotein	701..787	CDD:279782	38/89 (43%)
		FU	1320..>1350	CDD:214589	10/29 (34%)
PCSK5	NP_001358972.1	S8_pro-domain	38..114	CDD:374560	29/78 (37%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	126..420	CDD:173789	192/293 (66%)
		P_proprotein	505..595	CDD:366670	38/89 (43%)
		Cell attachment site. /evidence=ECO:0000255	519..521		1/1 (100%)
		FU 1	630..680		10/49 (20%)
		GF_recep_IV	635..744	CDD:373332	23/140 (16%)
		VSP	724..1100	CDD:146106	68/478 (14%)
		FU	1084..1129	CDD:238021	7/57 (12%)
		FU	1126..1162	CDD:214589	12/42 (29%)
		FU	1209..1256	CDD:238021
		VSP	1291..>1576	CDD:146106
		GF_recep_IV	1596..1713	CDD:373332
		FU	1695..1736	CDD:214589
		AC 1. /evidence=ECO:0000250	1834..1853
		AC 2. /evidence=ECO:0000250	1865..1887
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820