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Protein Alignment Fur1 and FURIN

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001276752.1	Gene:	FURIN / 5045	HGNCID:	8568	Length:	794	Species:	Homo sapiens

Alignment Length:	647	Identity:	343/647 - (53%)
Similarity:	421/647 - (65%)	Gaps:	57/647 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRV 295
            :|:||||.||.|. .:|::||:.|||:|||:||.|:|||.|..|:||||||.....:||..:.:|
Human    30 FTNTWAVRIPGGP-AVANSVARKHGFLNLGQIFGDYYHFWHRGVTKRSLSPHRPRHSRLQREPQV 93

  Fly   296 HWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMG 360
            .|.:||.||.|:||| :...|:                |.|:||.|||:.....|:||..||..|
Human    94 QWLEQQVAKRRTKRD-VYQEPT----------------DPKFPQQWYLSGVTQRDLNVKAAWAQG 141

  Fly   361 ITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATA 425
            .||.|:||:|||||:|.:|||:..||||.||:|||..|.||.|.|...:.|||||||||||||.|
Human   142 YTGHGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVA 206

  Fly   426 NNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELAS 490
            ||..|.||:||.|.:||||||||:||||||||||.|||.||.||||||||:|||||||||..||.
Human   207 NNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARLAE 271

  Fly   491 RAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSST 555
            .||..|.::||||.||||:|||||||||.|:||||||||||:||||||||:.|:||||||.||||
Human   272 EAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSST 336

  Fly   556 LATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTA 620
            ||||||||.|.|||:|||||...||.|||||||||||||||.||.|::|:||||||:||:||:|:
Human   337 LATTYSSGNQNEKQIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTS 401

  Fly   621 KPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTH 685
            |||:|....|:.|||||:||||:||||:||..||.:|:||..|..|::|.|:.....|.|..|..
Human   402 KPAHLNANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLE 466

  Fly   686 ITLQLTV-----NHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGF 745
            :...:|.     ||   :..|||.||::||:..||||:.:.|.||..|..|||..|.||.|..||
Human   467 VRKTVTACLGEPNH---ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGF 528

  Fly   746 NQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKP---SG 807
            |.|.||:.|:|.|.|.|.|.|||.|......:..|.:::|:.|||.       |..:|.|   ||
Human   529 NDWAFMTTHSWDEDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTA-------PEGLPVPPESSG 586

  Fly   808 SEATTPNSSSTTS----NLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNN 865
            .:..|.:.:....    :|||....|:  .||               |..|....:.|.|.|
Human   587 CKTLTSSQACVVCEEGFSLHQKSCVQH--CPP---------------GFAPQVLDTHYSTEN 631

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.