DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and TppII

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_725252.1	Gene:	TppII / 36444	FlyBaseID:	FBgn0020370	Length:	1441	Species:	Drosophila melanogaster

Alignment Length:	1638	Identity:	308/1638 - (18%)
Similarity:	525/1638 - (32%)	Gaps:	539/1638 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 FLTQHKQ----KRSGKSSSKSKSNRSRPLAKTKAVFL--LALQFSAVVFLCNINVGFVAGSVATA 147
            |...|||    |..|....|:....:.|:......::  :..:.|.|:........|...|..:.
  Fly     5 FRLVHKQLRLYKNFGLLGQKASVGLTLPIISLSRPYMAYMGTERSVVMITAPATKEFAESSERSN 69

  Fly   148 ASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVL------PPY--------VLD 198
            :|....:...:..||.|...|..:....|..:.:   |..::.||      |.|        :.|
  Fly    70 SSKKTTNKEQSDKSAESRMATSGIVESFPTGALV---PKAETGVLNFLQKYPEYDGRDVTIAIFD 131

  Fly   199 ------------------------YETGG------KAKLTPN-NGKF-GQSGSSGSNNNHIVGHY 231
                                    |:..|      |.|:||: ||.. |.||:|...:..::.
  Fly   132 SGVDPRATGLETLCDGKTVKVIERYDCSGCGDVDMKKKVTPDENGNIKGLSGNSLKLSPELMA-- 194

  Fly   232 THTWAVHIPNGDNGMADAVAKDHGFVNLG-KIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRV 295
                    .|.|...|         |.:| |.|.|             |.|:......:......
  Fly   195 --------LNTDPEKA---------VRVGLKSFSD-------------LLPSKVRNNIVAQAKLK 229

  Fly   296 HWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFND---SKWPQMW---YLNRGGGLDMNVI 354
            ||.|..:              :.|::.:..:|:..|.|.   ||.|  |   .|......::.::
  Fly   230 HWDKPHK--------------TATANASRKIVEFESQNPGEASKLP--WDKKILKENLDFELEML 278

  Fly   355 PAWK-------------MGITGKGVVVTI-------LDDGL---ESDHPDIQDNYDPKASYDVNS 396
            .:::             :..|..|.:..:       ||..|   |........|.|...|..||.
  Fly   279 NSYEKVYGDIKTSYDCILFPTADGWLTIVDTTEQGDLDQALRIGEYSRTHETRNVDDFLSISVNV 343

  Fly   397 HDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAV-GIAYGASVGGVRMLDGDV------TDAV 454
            ||:..:... :..|:.|||..:.  .|:.|:|...| |:|..|.:..:.:.||.:      |..|
  Fly   344 HDEGNVLEV-VGMSSPHGTHVSS--IASGNHSSRDVDGVAPNAKIVSMTIGDGRLGSMETGTALV 405

  Fly   455 EARS----LSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNG 515
            .|.:    |..:.:.||:.:.|:|...:.......|||.:    |...|    .|.:::.::||.
  Fly   406 RAMTKVMELCRDGRRIDVINMSYGEHANWSNSGRIGELMN----EVVNK----YGVVWVASAGNH 462

  Fly   516 GREQDNCNCDGYTNSIWTL----SISSATEEGHVPWYS-----------EKCSSTLATTYS---- 561
            |            .::.|:    .||..:..|...:.|           ||....:.|..|
  Fly   463 G------------PALCTVGTPPDISQPSLIGVGAYVSPQMMEAEYAMREKLPGNVYTWTSRDPC 515

  Fly   562 -SGGQGEKQVVTTDLHHSC------------TVSHT----GTSASAPLAAGIAALVLQ--SNQNL 607
             .||||    ||.     |            |:|.:    |||.:||..||..||::.  ..||:
  Fly   516 IDGGQG----VTV-----CAPGGAIASVPQFTMSKSQLMNGTSMAAPHVAGAVALLISGLKQQNI 571

  Fly   608 TWR--DLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAE------------------ 652
            .:.  .::..:..||......||            .:.|:||::..:
  Fly   572 EYSPYSIKRAISVTATKLGYVDP------------FAQGHGLLNVEKAFEHLTEHRQSKDNMLRF 624

  Fly   653 MVRVARNW-KAVPEQQRCEINA--------P--HVDKVIPPRTHITLQLTVNHCRSVNYLEHVQA 706
            .|||..|. |.:..:|..:.|:        |  :.||...|:......:.:|...|..:   ||.
  Fly   625 SVRVGNNADKGIHLRQGVQRNSIDYNVYIEPIFYNDKEADPKDKFNFNVRLNLIASQPW---VQC 686

  Fly   707 KITLTSQRRGDIQLFLRSPA-NTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHN 770
            ...|      |:....||.| ....|.|.|.:|.
  Fly   687 GAFL------DLSYGTRSIAVRVDPTGLQPGVHS------------------------------- 714

  Fly   771 EGRYMGHALLREW--SLIFYGTTQSIGPNDPISVPKPS--GSEATTPNSSSTTSNLHQAYSPQYP 831
                   |::|.:  ..:..|:...|    |::|.:|.  .|:..||.....:|....:...| |
  Fly   715 -------AVIRAYDTDCVQKGSLFEI----PVTVVQPHVLESDQNTPVFEPASSKGDNSVEFQ-P 767

  Fly   832 RIPPNNFGSSPSGGSKLPLG-KVPPPNKSS-----YVTNNPLLNSAPPKQGYQQISATYGVILGK 890
            .....:|...|...:...|. ::..||:..     :|..|.||    |||..:::.....|.:|.
  Fly   768 NTIQRDFILVPERATWAELRMRITDPNRGEDIGKFFVHTNQLL----PKQSCRKLETMKIVSVGS 828

  Fly   891 ANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQQKN 955
            .                |:|....|.|||             .|::...:  ||:....|...|.
  Fly   829 E----------------NESIMAFKVKSG-------------RILELCIA--KYWSNYGQSHLKY 862

  Fly   956 NKQDRNGVQTQRPKA---NSGEKSYDEKSRKVVGE-----ITTNSGNGSIKAAKQVKESTTTSSN 1012
            :.:.| ||:...|.|   ::|...:..:...:|.|     :...:....:|.. :.|.|..:::.
  Fly   863 SLRFR-GVEAHNPNAYVMHAGRGIHKLEIEALVAEDVQPQLQLKNAEVVLKPT-EAKISPLSATR 925

  Fly  1013 SRIPKLFERYEKIQA----------------IFPEL------------------------EPYEN 1037
            ..||...:.|:.:.|                ||.:|                        :.:.:
  Fly   926 DVIPDGRQVYQNLLAFNLNVAKAADVSIYAPIFNDLLYEAEFESQMWMLFDANKALVATGDAHSH 990

  Fly  1038 SS----PKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPSV-------------------PP 1079
            :|    .||:.....|.:..:.||.:..:..|........||..                   .|
  Fly   991 TSFTKLDKGEYTIRLQVRHEKRDLLEKISEANLVASFKLTSPLTLDFYENYNQCIVGGRKYVSSP 1055

  Fly  1080 PSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAA---GVMAPAQVEVEMEEVHATPDYEAR 1141
            ...:...|.|.||          .|:.|.|..|....|   |.:...|.||..........|...
  Fly  1056 LRLSTRVLYIAPI----------TQERLTKANLPAQCAWLSGNLVFPQDEVGRRVAQHPFTYILN 1110

  Fly  1142 KDQRK-EVNGPN------------AQITQWDMIFYGTE-----TPAQPDDVANPSQSNQFNLYGN 1188
            ..::| ..||.:            |.:|..:    |.:     ||.....|.||:..:..::
  Fly  1111 PAEKKSHTNGSSNGSSAAGSTATAAAVTTAN----GAKPKAPATPQAATSVTNPAAGDGISV--- 1168

  Fly  1189 DMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLECNDSAYMFEDQCY-DVCPV 1252
               .||...||:|...:.:: |:.. ..|::.:     :.|.:|.:.........::.| ||...
  Fly  1169 ---QNDPPVDSSGSPASPKK-GKAN-ADDYAES-----FRDFQCSQIVKCELEMAEKIYNDVVAA 1223

  Fly  1253 HTYPLDKFQA--------EEDEQDDEVTRGPVNPYSSSPMDHSLLMSNSLDDKQDPLQAEDRRR- 1308
            |...|   ||        |.::...::....||...:||.:     :....||    |.||:::
  Fly  1224 HPKHL---QANLLLIQNIESNQLKSQLPLTFVNAQKTSPPE-----AGESADK----QKEDQKKV 1276

  Fly  1309 RSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQLRKILNETFCYAYVVRSTGMASVV 1373
            ||:|.::|::..:|....|...|..|..|.                |:|              ..
  Fly  1277 RSALERIVKLADKVIQETDSEALLSYYGLK----------------NDT--------------RA 1311

  Fly  1374 DISKMDDRDTQQYMTGTTVLLLVSVIFTLMGVAVAGGIVYH---RRAMARSNELYSR-VSLVPGD 1434
            |.:|:.....:|..|      |:..: :..|:|||...|..   :.::|..||||:. :..|..:
  Fly  1312 DAAKIKTNMDKQKNT------LIEAL-SKKGIAVAKLAVLDDCIKDSLAEINELYTEIIKFVDAN 1369

  Fly  1435 ESDSDEDELFTAH 1447
            :|.:.:..|:.|:
  Fly  1370 DSKAIQFALWHAY 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	13/75 (17%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	79/368 (21%)
		Peptidase_S8	363..646	CDD:278510	76/343 (22%)
		P_proprotein	701..787	CDD:279782	13/88 (15%)
		FU	1320..>1350	CDD:214589	5/29 (17%)
TppII	NP_725252.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	101..589	CDD:173796	114/570 (20%)
		Peptidase_S8	331..600	CDD:278510	71/312 (23%)
		TPPII	892..1073	CDD:289357	27/191 (14%)
		TPPII_N	1144..1257	CDD:289360	24/128 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900