DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and mbtps1

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_954683.2	Gene:	mbtps1 / 326710	ZFINID:	ZDB-GENE-030131-4909	Length:	1074	Species:	Danio rerio

Alignment Length:	1005	Identity:	188/1005 - (18%)
Similarity:	291/1005 - (28%)	Gaps:	431/1005 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 VVFLCNINVGFVAGSVATAASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLP 193
            :|.|| :.|.|:           |...|...:...|.|.....|||.|.::...:.||.....|.
Zfish     2 IVRLC-LLVAFL-----------GAKLPLVGTEEDSGPFLTPFPPPLPLNADAHLSPNCSQLTLK 54

  Fly   194 PYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDHGFVN 258
               ||:.|                        .:|   .|.:.|..    ||...|.|:. .|::
Zfish    55 ---LDFST------------------------QVV---KHEYIVAF----NGYFTAKARS-DFIS 84

  Fly   259 LGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRS-----------KRD-- 310
                                        :.|.|.|.|.|...:|....|           |:|
Zfish    85 ----------------------------SALRDVDAVKWRIVRRDNPASDYPSDFEVVEIKQDTR 121

  Fly   311 ----------FI-RMRPSRTSSRAMSMVD-----AMSFNDSKWPQMWY------------LNRGG 347
                      :| |:.|.|...|::...|     |...||::|.|.|.            |:...
Zfish   122 NSLLTLQDHPYIKRVTPQRMVLRSLKFTDSGTDGASPCNDTRWVQKWQSWQSSRPLRRTSLSLSS 186

  Fly   348 GL-----------DMNVIP-----------AWKMGITGKGVVVTILDDGLESDHPDIQD-----N 385
            |.           .:..||           .|:||.||.||.|.:.|.||...||..::     |
Zfish   187 GFWHATGRHSSRRLLRAIPRHVAQILQADVLWQMGHTGSGVKVAVFDTGLSEKHPHFKNVKERTN 251

  Fly   386 YDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV 450
            :..:.:.|               |...|||..||.:|:...   |. |.|..:.:...|:.   .
Zfish   252 WTNEKTLD---------------DGLGHGTFVAGVIASMRE---CQ-GFAPDSELHIFRVF---T 294

  Fly   451 TDAVEARSLSLNP------QHIDIYSASWGPDD--DGKTVDGPGELASRAFIEGTTKGRGGKGSI 507
            .:.|...|..|:.      :.||:.:.|.|..|  |...||...||.:...             |
Zfish   295 NNQVSYTSWFLDAFNYAILKKIDVLNLSIGGPDFMDHPFVDKVWELTANKV-------------I 346

  Fly   508 FIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTL------------ATTY 560
            .:.|.||.|......|  ...:.:..:.:.....|.::..:|.:..:|.            ..||
Zfish   347 MVSAIGNDGPLYGTLN--NPADQMDVIGVGGIDFEDNIARFSSRGMTTWELPGGYGRVKPDIVTY 409

  Fly   561 SSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDL------------- 612
            .||.:|      :.|...|. |.:|||.::|:.||...|:..:..|   |:|
Zfish   410 GSGVRG------SGLKEGCR-SLSGTSVASPVVAGAVTLLASTVLN---RELVNPASMKQALIAS 464

  Fly   613 ---------------------QHIVVRTAKP-ANL------------------------------ 625
                                 .:.::.:.|| |:|
Zfish   465 ARRLPGVNMFEQGHGKLDLLRAYQILNSYKPQASLSPSYIDLTECPYMWPYCSQPIYYGGMPTIV 529

  Fly   626 ---------------KDPSWS----RNG--VGRRVSHS------FGY---------------GLM 648
                           :.|.|.    :||  |...||:|      .||               |:.
Zfish   530 NVTILNGMGVTGRIVEKPIWQPYLPQNGDYVDVAVSYSPVLWPWAGYLAVSISVAKKAASWEGIA 594

  Fly   649 DAAEMVRV---ARNWKAVPEQQRCEINAPHVDKVI--PPRT------------------------ 684
            ....||.|   |.|..|:..:....:..|...|::  |||:
Zfish   595 QGHVMVTVASPAENDSAIGGEMTSTVKLPVKVKIVPTPPRSKRILWDQYHNLRYPPGYFPRDNLR 659

  Fly   685 -------------HITLQLTVNHCRSVNY-LEHVQAKIT-----------------------LTS 712
                         |...:....|.||:.| :|.:.|.||                       :|.
Zfish   660 MKNDPLDWNGDHIHTNFRDMYQHLRSMGYFVEVLGAPITCFDASQYGTLLMVDSEEEYFPEEITK 724

  Fly   713 QRR---GDIQLFLRSP-ANTSVTLLTPRIHDNSRSGFNQW----------PFMS--VHTWGESPQ 761
            .||   ..:.|.:.|. .||||........:|:|    ||          |.::  :..||.:
Zfish   725 LRRDIDNGLSLIVFSDWYNTSVMRKVKFYDENTR----QWWMPDTGGANVPALNDLISVWGMA-- 783

  Fly   762 GNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIG--PNDPISVP---KPSGSEATTPNSSSTTSN 821
                   .::|.|.|...|.:..: :|.:..||.  |.|.|.:.   |..|.|.....::...:
Zfish   784 -------FSDGLYEGDFTLADHDM-YYASGCSIARFPEDGIVIAQTLKDQGLEVLKQETAVVEN- 839

  Fly   822 LHQAYSPQYPRIPPNNFGSSPS-GGSKLPL 850
                       :|......:|| ||.::.|
Zfish   840 -----------VPVLGLYQTPSDGGGRIAL 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	13/85 (15%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	75/381 (20%)
		Peptidase_S8	363..646	CDD:278510	76/414 (18%)
		P_proprotein	701..787	CDD:279782	24/124 (19%)
		FU	1320..>1350	CDD:214589
mbtps1	NP_954683.2	Peptidases_S8_SKI-1_like	218..470	CDD:173805	66/298 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900