DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and Pcsk9

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_954862.2	Gene:	Pcsk9 / 298296	RGDID:	728909	Length:	691	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	139/718 - (19%)
Similarity:	235/718 - (32%)	Gaps:	251/718 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 IFDDHYHFA---HHKVSKRSLS-PATHHQTRLDDDDRVH----------WAKQQRAKSRSKRDFI 312
            :.|:..|.|   ..:.||.:.. |.|:....:::..|:.          ||.::....:....|.
  Rat    51 LVDEASHVATATFRRCSKEAWRLPGTYVVVLMEETQRLQVEQTAHRLQTWAARRGYVIKVLHVFY 115

  Fly   313 RMRPS---RTSSRAMSMV-----------DAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITG 363
            .:.|.   :.||..:.:.           |::.|..|   ..|.|.|       :||||:.....
  Rat   116 DLFPGFLVKMSSDLLGLALKLPHVEYIEEDSLVFAQS---IPWNLER-------IIPAWQQTEED 170

  Fly   364 KG------VVVTILDDGLESDHPDIQDNYDPKASYDVNS--HDDDPMPHYDMTDSNRHGTRCAGE 420
            ..      |.|.:||..::|.|.:|:...   ...|.||  .:|....|...:..:.|||..||.
  Rat   171 SSPDGSSQVEVYLLDTSIQSGHREIEGRV---TITDFNSVPEEDGTRFHRQASKCDSHGTHLAGV 232

  Fly   421 VAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGP 485
            |:..      ..|:|.|.|:..:|:|:......|....:.|     :....|       :.:...
  Rat   233 VSGR------DAGVAKGTSLHSLRVLNCQGKGTVSGTLIGL-----EFIRKS-------QLIQPS 279

  Fly   486 GELA---------SRAFIEGTTKGRGGK-GSIFIWASGNGGREQDNC-NCDGYTNSIWTLSISSA 539
            |.|.         ||  |..|...|..: |.:.:.|:||  ...|.| ........:.|:..::|
  Rat   280 GPLVVLLPLAGGYSR--ILNTACQRLARTGVVLVAAAGN--FRDDACLYSPASAPEVITVGATNA 340

  Fly   540 TEEGHVPWYSEKCSSTLATTYSSGGQ-------GEKQVVTTDLHHSCTVSHTGTSASAPLAAGIA 597
            .::          ..||.|..::.|:       |:..:..:....:|.:|.:|||.:|...|||.
  Rat   341 QDQ----------PVTLGTLGTNFGRCVDLFAPGKDIIGASSDCSTCYMSQSGTSQAAAHVAGIV 395

  Fly   598 ALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKA 662
            |::|..:..||..:|:..::                             |....:::.:|  |
  Rat   396 AMMLNRDPALTLAELRQRLI-----------------------------LFSTKDVINMA--W-- 427

  Fly   663 VPEQQRCEINAPHVDKVIPPRTHIT-LQLTVNHCRSVNYLEHVQAKITLTS-------------- 712
            .||.||  :..|:....:||.|..| .||.   ||:| :..|.....|.|:
  Rat   428 FPEDQR--VLTPNRVATLPPSTQETGGQLL---CRTV-WSAHSGPTRTATATARCAPEEELLSCS 486

  Fly   713 ------QRRGD---------IQLFLRSPANTSV-----TLLTPR----IHDN--SRSGFNQWPFM 751
                  :||||         :...|.:.....|     ..|.||    ||:.  :|:|    |..
  Rat   487 SFSRSGRRRGDRIEAIGGQQVCKALNAFGGEGVYAVARCCLLPRVNCSIHNTPAARAG----PQT 547

  Fly   752 SVHTWGESP-----QGNWQLE------------IHNEGRYMGH----------------ALLREW 783
            .||...:..     ..:|::|            .|..|:.:||                ..::|.
  Rat   548 PVHCHQKDHVLTGCSFHWEVENLRAQQQPLLRSRHQPGQCVGHQEASVHASCCHAPGLECKIKEH 612

  Fly   784 SLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKL 848
            .:        .||.:.::|...:|...|                           |.:...|:.|
  Rat   613 GI--------AGPAEQVTVACEAGWTLT---------------------------GCNVLPGASL 642

  Fly   849 PLG 851
            |||
  Rat   643 PLG 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	10/60 (17%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	70/314 (22%)
		Peptidase_S8	363..646	CDD:278510	61/308 (20%)
		P_proprotein	701..787	CDD:279782	26/158 (16%)
		FU	1320..>1350	CDD:214589
Pcsk9	NP_954862.2	Inhibitor_I9	76..148	CDD:283552	9/71 (13%)
		Peptidases_S8_PCSK9_ProteinaseK_like	155..420	CDD:173790	69/335 (21%)
		Peptidase_S8	179..415	CDD:278510	61/270 (23%)
		C-terminal domain. /evidence=ECO:0000250	449..691		43/240 (18%)
		Cell attachment site. /evidence=ECO:0000255	495..497		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900