DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and PCSK9

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_777596.2	Gene:	PCSK9 / 255738	HGNCID:	20001	Length:	692	Species:	Homo sapiens

Alignment Length:	661	Identity:	138/661 - (20%)
Similarity:	234/661 - (35%)	Gaps:	212/661 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 DNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLS-PATH-----HQTRLDDDDRVHWAKQQ 301
            ::|:|:  |.:||..           ...|:.:|.... |.|:     .:|.|...:|.  |::.
Human    49 EDGLAE--APEHGTT-----------ATFHRCAKDPWRLPGTYVVVLKEETHLSQSERT--ARRL 98

  Fly   302 RAKSRSKRDFIR--------MRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWK 358
            :|:: ::|.::.        :.|......:..:::..    .|.|.:.|:.....:....|| |.
Human    99 QAQA-ARRGYLTKILHVFHGLLPGFLVKMSGDLLELA----LKLPHVDYIEEDSSVFAQSIP-WN 157

  Fly   359 M-GIT--------------GKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMT 408
            : .||              |..|.|.:||..::|||.:|:..        |...|.:.:|..|.|
Human   158 LERITPPRYRADEYQPPDGGSLVEVYLLDTSIQSDHREIEGR--------VMVTDFENVPEEDGT 214

  Fly   409 DSNR-------HGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHI 466
            ..:|       |||..||.|:..      ..|:|.|||:..:|:|:......|....:.|
Human   215 RFHRQASKCDSHGTHLAGVVSGR------DAGVAKGASMRSLRVLNCQGKGTVSGTLIGL----- 268

  Fly   467 DIYSASWGPDDDGKTVDGPGELA---------SRAFIEGTTKGRGGKGSIFIWASGNGGREQDNC 522
            :....|       :.|...|.|.         ||. :....:.....|.:.:.|:||  ...|.|
Human   269 EFIRKS-------QLVQPVGPLVVLLPLAGGYSRV-LNAACQRLARAGVVLVTAAGN--FRDDAC 323

  Fly   523 -NCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQ-------GEKQVVTTDLHHSC 579
             ........:.|:..::|.::          ..||.|..::.|:       ||..:..:....:|
Human   324 LYSPASAPEVITVGATNAQDQ----------PVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTC 378

  Fly   580 TVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFG 644
            .||.:|||.:|...|||||::|.:...||..:|:                       :|:.|
Human   379 FVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELR-----------------------QRLIH--- 417

  Fly   645 YGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTH-ITLQLTVNHCRSVNYLEHVQ--- 705
               ..|.:::..|  |  .||.||  :..|::...:||.|| ...||   .||:| :..|..
Human   418 ---FSAKDVINEA--W--FPEDQR--VLTPNLVAALPPSTHGAGWQL---FCRTV-WSAHSGPTR 469

  Fly   706 -----------------AKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPF--- 750
                             :..:.:.:|||:     |..|...  .|..|.| |:..|...:..
Human   470 MATAVARCAPDEELLSCSSFSRSGKRRGE-----RMEAQGG--KLVCRAH-NAFGGEGVYAIARC 526

  Fly   751 -------MSVHTW--GESPQGNWQLEIHNEGRYMGHALL---REWSLIFYGTTQSIGPNDPISVP 803
                   .||||.  .|:..|. ::..|.:    ||.|.   ..|.:      :.:|.:.| .|.
Human   527 CLLPQANCSVHTAPPAEASMGT-RVHCHQQ----GHVLTGCSSHWEV------EDLGTHKP-PVL 579

  Fly   804 KPSGSEATTPN 814
            :|.|.    ||
Human   580 RPRGQ----PN 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	14/71 (20%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	74/327 (23%)
		Peptidase_S8	363..646	CDD:278510	68/306 (22%)
		P_proprotein	701..787	CDD:279782	22/120 (18%)
		FU	1320..>1350	CDD:214589
PCSK9	NP_777596.2	Inhibitor_I9	77..149	CDD:283552	11/78 (14%)
		Peptidases_S8_PCSK9_ProteinaseK_like	156..421	CDD:173790	71/332 (21%)
		Peptidase_S8	180..422	CDD:278510	68/309 (22%)
		C-terminal domain	450..692		34/165 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900