DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and tpp2

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_594951.1	Gene:	tpp2 / 2543179	PomBaseID:	SPAP8A3.12c	Length:	1274	Species:	Schizosaccharomyces pombe

Alignment Length:	1095	Identity:	193/1095 - (17%)
Similarity:	342/1095 - (31%)	Gaps:	342/1095 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 HKVSKRSLSPATHHQTRLD--------DDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVD 328
            :|.:::.|..||....:..        |.|.:...|:..|:....:..     :........:.|
pombe   199 NKSNRKLLQDATDEYAKFKDKFPEAPLDKDNLQTQKELEARIECLKQL-----AEKFDNPGPLYD 258

  Fly   329 AMSFNDSK-WPQMWYLNRGGGL-------DMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDN 385
            .:.|:|.: |..:...::.|.:       |.||...|.        ....||
pombe   259 VVVFHDGEHWRVVIDSDQTGDIYLHKPLADFNVAQEWS--------TFGSLD------------- 302

  Fly   386 YDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV 450
               ..||.|:.:|:..:... :..|..|||..||.:.|....:....|.|.|..:..:.:.||.:
pombe   303 ---LLSYGVHVYDNGNITSI-VAVSGTHGTHVAGIIGANHPETPELNGAAPGCQLVSLMIGDGRL 363

  Fly   451 TDAVE-----ARSLS-LNPQHIDIYSASWGPD----DDGKTVD-GPGELASRAFIEGTTKGRGGK 504
             |::|     :|:.| :....:||.:.|:|.|    :.|:.:: ...|||.:..:. .....|..
pombe   364 -DSLETSHAFSRACSEIIKNEVDIINISFGEDAGIPNKGRVIELLRDELAGKRNVV-IVSSAGNN 426

  Fly   505 GSIFIWASGNGGREQDNCNCDGYTNSIW---TLSISSATEEGHVPWYSEKCS-------STLATT 559
            |..:......||...|..:...|..|..   ..::.|...:....|    ||       .|..:.
pombe   427 GPAYTTVGAPGGTTFDVISVGAYVTSGMMQAQYNLLSTVHDTPYTW----CSRGPTLDGDTGVSI 487

  Fly   560 YSSGGQGEKQVVTTDLHHSCTVSH--TGTSASAPLAAGIAALVLQS----NQNLTWRDLQHIVVR 618
            |:.||     .:|:...:|...|.  .|||.|:|.|.|..:|:|.:    .:..|...::..|:.
pombe   488 YAPGG-----AITSVPPYSLQNSQLMNGTSMSSPSACGGISLILSALKAQKKPYTAAAIKKAVMY 547

  Fly   619 TAKPANLKDPSWSRNGVGRRVSHSFGY---------GLMDAAEMVRVARNWKAVPEQQRCEINAP 674
            |:|  :|:|   ..|....:|.:::.|         |.........:..:.:.|..:...|:.:|
pombe   548 TSK--DLRD---DFNTGMLQVDNAYEYLAQSDFQYTGARSFTINGNIGNSKRGVYLRNPTEVCSP 607

  Fly   675 --HVDKVIP--------PRTHITLQLTVNHCRSVNYLEHVQAK--ITLTSQRRGDIQLFLRSPAN 727
              |:..|.|        .::|..:||::     ......:||.  :.:....||       .|..
pombe   608 SRHMFNVAPKFEDGEEYEKSHFEVQLSL-----ATTQPWIQAPEYVMMAGTGRG-------IPVR 660

  Fly   728 TSVTLLTPRIH----------DNSRSGFNQWPFMSVHTWGES----------------------- 759
            ...|.|.|..|          :.||....:.|...:.....|
pombe   661 VDPTALAPGHHFGKVLAYDASNESRRCVFEIPVTVMKPSSISNTCFSLRDVSFEPTLIKRHFLVP 725

  Fly   760 PQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSN--- 821
            |:|...:||    |....:.|...::::....|:|        |:...:||:|......|.|
pombe   726 PKGATYVEI----RVKATSELESTNMLWISVNQTI--------PQTKLNEASTELIMPVTQNEVT 778

  Fly   822 -----LHQAYS-------------PQYPRIPPNNFGSSPSGGSKLPL-----------GKVPPPN 857
                 :..:|:             |....|..|..|.....|.::.|           ..:...|
pombe   779 TKLVSIDDSYTLELCMAQWWSSLEPMVLDIDVNFHGIKVVNGKEINLISSQGLKRVDCASIRREN 843

  Fly   858 KSSYVTNNPLLNSAPP--------------KQGYQ--QISATYGVILGKANGKSNNNSKEKTNNK 906
            ....:|....::|..|              ..|.|  ::.|||.|.:           .|||..|
pombe   844 FKPDITLKDYVDSFKPTNTVIKPLGDRDIMPDGQQLFELMATYSVEI-----------SEKTELK 897

  Fly   907 G------NKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQT 965
            .      |..:||..|                          .::.:...|:|:.:..|   :.|
pombe   898 ADFAVPHNMYDNGFNG--------------------------LFFMVFDSQKQRVHYGD---MYT 933

  Fly   966 QRPKANSGEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNSRIP-----------KLF 1019
            .......||..|..:...|.........|.:::..|::|:..|      :|           |.:
pombe   934 SSHTLEKGEYLYKFQLLSVDPSTLERFRNVTLRLTKKLKKPIT------LPLYADHIDFCDNKTY 992

  Fly  1020 ERYEKIQAIFPEL---------EPY-----ENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGN 1070
            || |.|.|...|.         |.|     |||...|:.|                 .|:..:|.
pombe   993 ER-ENIDAGVVESFVVGTNIEGEQYASELKENSLLTGELK-----------------FGDCEKGT 1039

  Fly  1071 TKKSPSVPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHAT 1135
            ...:..:||...|.                 .|.|:.:|      .|.:     |:::::.:...
pombe  1040 VPVTLVLPPKISTK-----------------EDTKLGEK------CANI-----VQLQVDLLSKL 1076

  Fly  1136 PDYEARKD----QRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLY 1186
            .|.|..|.    |....|....|:.:.|::....|..:..|.:.:...:...:.|
pombe  1077 ADQEKEKHLKYLQSSYKNSLEVQLAKLDIVKETNERLSTADSILSLIDTEALSRY 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	8/44 (18%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	69/323 (21%)
		Peptidase_S8	363..646	CDD:278510	67/318 (21%)
		P_proprotein	701..787	CDD:279782	19/120 (16%)
		FU	1320..>1350	CDD:214589
tpp2	NP_594951.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	71..552	CDD:173796	79/395 (20%)
		Peptidase_S8	271..552	CDD:278510	67/318 (21%)
		TPPII	837..1008	CDD:289357	38/217 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42884
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000