DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and Tpp2

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_033444.1	Gene:	Tpp2 / 22019	MGIID:	102724	Length:	1262	Species:	Mus musculus

Alignment Length:	747	Identity:	145/747 - (19%)
Similarity:	252/747 - (33%)	Gaps:	210/747 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 PPSSALKVDPNGQSPVLPPYVLD-YETGGK------AKLTPNNGK-FGQSG---SSGSNNNHIVG 229
            |.:..::|..:|:     |.::| .:|.|.      .::.|.:|: .|.||   ...:|..:.:|
Mouse    49 PGAPGMQVTTDGK-----PKIIDIIDTTGSGDVNTATEVEPKDGEIIGLSGRVLKIPANWTNPLG 108

  Fly   230 HYTHTWAVHIPNG----DNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLD 290
            .| |   :.|.||    ...:.:.:.|:    ...||:|     ..|:|   :|:.|...|...|
Mouse   109 KY-H---IGIKNGYDFYPKALKERIQKE----RKEKIWD-----PIHRV---ALAEACRKQEEFD 157

  Fly   291 DDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIP 355
            ..:.    ...:|....|.:.            .|.|:.::..:.|     |.:.|...|..|
Mouse   158 IANN----GSSQANKLIKEEL------------QSQVELLNSFEKK-----YSDPGPVYDCLV-- 199

  Fly   356 AWKMGITGKGVVVTILDDGLESDHPDIQD-----NYD-----------PKASYDVNSHDDDPMPH 404
             |..|.|.:..|.:       :::.|:..     ||.           ...:|.||.:||..:..
Mouse   200 -WHDGETWRACVDS-------NENGDLSKCAVLRNYKEAQEYSSFGTAEMLNYSVNIYDDGNLLS 256

  Fly   405 YDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDV--------TDAVEARSLSL 461
            . :|....|||..|...|..........|:|.||.:..:::  ||.        |..:.|....:
Mouse   257 I-VTSGGAHGTHVASIAAGHFPEEPERNGVAPGAQILSIKI--GDTRLSTMETGTGLIRAMIEVI 318

  Fly   462 NPQHIDIYSASWGP----DDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNC 522
            | ...|:.:.|:|.    .:.|:..    |:.:.|..:..|        |::.::||.|......
Mouse   319 N-HKCDLVNYSYGEATHWPNSGRIC----EVINEAVWKHNT--------IYVSSAGNNGPCLSTV 370

  Fly   523 NCDGYTNS--------------IWTLSISSATEEGHVPWYSE--KCSSTLATTYSSGGQGEKQVV 571
            .|.|.|.|              :...|:..........|.|.  .....|..:.|:.|.....|.
Mouse   371 GCPGGTTSSVIGVGAYVSPDMMVAEYSLREKLPANQYTWSSRGPSADGALGVSISAPGGAIASVP 435

  Fly   572 TTDLHHSCTVSHTGTSASAPLAAGIAALVLQ----SNQNLTWRDLQHIVVRTAKPANLKDPSWSR 632
            ...|..  |....|||.|:|.|.|..||||.    :|.:.|...::..:..||..|:..:.....
Mouse   436 NWTLRG--TQLMNGTSMSSPNACGGIALVLSGLKANNVDYTVHSVRRALENTAIKADNIEVFAQG 498

  Fly   633 NGVGRRVSHSFGYGLMDAAEMVRV-----ARNWKAVPEQQRCEINAPH-----VDKVIPPRT--- 684
            :|: .:|..::.|.:.:.:...|:     ..|.:.:..:...::.||.     ::.|.|..|
Mouse   499 HGI-IQVDKAYDYLIQNTSFANRLGFTVTVGNNRGIYLRDPVQVAAPSDHGVGIEPVFPENTENS 562

  Fly   685 -----HITLQLTVN--------HCRSVNYLEHVQAKITLTSQRRG---------DI------QLF 721
                 .:.|.||.|        |...:|...|:..::.....|.|         ||      .||
Mouse   563 EKISFQLHLALTSNSSWVQCPSHLELMNQCRHINIRVDPRGLREGLHYTEVCGYDIASPNAGPLF 627

  Fly   722 LRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVH-----------------TWGE------SPQGN 763
             |.|.   ..::..:::::|....   .|..||                 ||.|      |.:.:
Mouse   628 -RVPI---TAVIAAKVNESSHYDL---AFTDVHFKPGQIRRHFVEVPEGATWAEVTVCSCSSEVS 685

  Fly   764 WQLEIH-----NEGRYMGHALLREWSLIFYGT 790
            .:..:|     .:..|..|...:..||...||
Mouse   686 AKFVLHAVQLVKQRAYRSHEFYKFCSLPEKGT 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	14/78 (18%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	70/336 (21%)
		Peptidase_S8	363..646	CDD:278510	66/330 (20%)
		P_proprotein	701..787	CDD:279782	22/128 (17%)
		FU	1320..>1350	CDD:214589
Tpp2	NP_033444.1	Peptidases_S8_Tripeptidyl_Aminopeptidase_II	14..489	CDD:173796	104/509 (20%)
		Peptidase_S8	236..500	CDD:278510	60/281 (21%)
		TPPII	777..960	CDD:289357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1010..1030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900