DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and Pcsk5

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001177412.1	Gene:	Pcsk5 / 18552	MGIID:	97515	Length:	1877	Species:	Mus musculus

Alignment Length:	1292	Identity:	417/1292 - (32%)
Similarity:	563/1292 - (43%)	Gaps:	343/1292 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSL--SPATHHQTRLDD 291
            ||:.|||.|..| ...||.:|..:||:|:|:|  ..|:|||.|.:..|||:  |..||  :.:..
Mouse    37 YTNHWAVKIAGG-FAEADRIASKYGFINVGQIGALKDYYHFYHSRTIKRSVLSSRGTH--SFISM 98

  Fly   292 DDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGL-----DM 351
            :.:|.|.:||..|.|:|||:           .:|...:..|||.|||.|||::.....     ||
Mouse    99 EPKVEWIQQQVVKKRTKRDY-----------DLSHAQSTYFNDPKWPSMWYMHCSDNTHPCQSDM 152

  Fly   352 NVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTR 416
            |:..|||.|.|||.:||||||||:|..|||:..|||..||.|||.:|.||||.||.::.|:||||
Mouse   153 NIEGAWKRGYTGKNIVVTILDDGIERTHPDLMQNYDALASCDVNGNDLDPMPRYDASNENKHGTR 217

  Fly   417 CAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKT 481
            ||||||||||||.|.||||:.|.:||||||||||||.|||:|:|.||||:.||||||||||||||
Mouse   218 CAGEVAATANNSHCTVGIAFNAKIGGVRMLDGDVTDMVEAKSVSYNPQHVHIYSASWGPDDDGKT 282

  Fly   482 VDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVP 546
            ||||..|..:||..|...||.|.||:|:||||||||.:|:|:||||||||:|:||||..|.|..|
Mouse   283 VDGPAPLTRQAFENGVRMGRRGLGSVFVWASGNGGRSKDHCSCDGYTNSIYTISISSTAESGKKP 347

  Fly   547 WYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRD 611
            ||.|:||||||||||||...:|:::||||...||.:|||||||||:||||.||.|::|..|||||
Mouse   348 WYLEECSSTLATTYSSGESYDKKIITTDLRQRCTDNHTGTSASAPMAAGIIALALEANPFLTWRD 412

  Fly   612 LQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHV 676
            :||::|||::..:|....|..|..|.:|||.:|:|||||..||..|..|..||:|..|..:....
Mouse   413 VQHVIVRTSRAGHLNANDWKTNAAGFKVSHLYGFGLMDAEAMVMEAEKWTTVPQQHVCVESTDRQ 477

  Fly   677 DKVIPPRTHITLQLTVNHC-----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPR 736
            .|.|.|.:.:......:.|     ..|||||||..:||:|..||||:.::|.||:.|...||..|
Mouse   478 IKTIRPNSAVRSIYKASGCSDNPNHHVNYLEHVVVRITITHPRRGDLAIYLTSPSGTRSQLLANR 542

  Fly   737 IHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGH----ALLREWSLIFYGTTQSIGPN 797
            :.|:|..||..|.||::|.|||...|:|.||:::....:.:    ..|:||||:.|||  |:.|.
Mouse   543 LFDHSMEGFKNWEFMTIHCWGERAAGDWVLEVYDTPSQLRNFKTPGKLKEWSLVLYGT--SVQPY 605

  Fly   798 DPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRI--PPNNFGSSPSGGSKLP-LGKV----PP 855
            .|                   |:...:....:|.|:  |.:::|:....|...| ..:|    |.
Mouse   606 SP-------------------TNEFPKVERFRYSRVEDPTDDYGAEDYAGPCDPECSEVGCDGPG 651

  Fly   856 PNKSS-------YVTNNP--LLNSAPP----------------------KQGYQQISATYGVILG 889
            |:..|       .:.||.  .::|.||                      ..|.|.:|..||..|.
Mouse   652 PDHCSDCLHYYYKLKNNTRICVSSCPPGHYHADKKRCRKCAPNCESCFGSHGNQCLSCKYGYFLN 716

  Fly   890 ------------------KAN--GKSNNNSK------EKTNNKGNKSNNGNKGKSGGSSGNRKEQ 928
                              |.|  ||.:.|.|      ..|..||..|..|::
Mouse   717 EETSSCVTQCPDGSYEDIKKNVCGKCSENCKACIGFHNCTECKGGLSLQGSR------------- 768

  Fly   929 TTQSTIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQTQRPK--------------ANSGEKSYDE 979
                  ...:....:::               ||...|...              .|..|....|
Mouse   769 ------CSVTCEDGQFF---------------NGHDCQPCHRFCATCSGAGADGCINCTEGYVME 812

  Fly   980 KSRKV----VGEITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSSP 1040
            :.|.|    |.....:|..|..|:.|:...|..|.:.......                  :|.|
Mouse   813 EGRCVQSCSVSYYLDHSSEGGYKSCKRCDNSCLTCNGPGFKNC------------------SSCP 859

  Fly  1041 KGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPSVPPPSQTMATLSILPILPAGGSSFLPDQK 1105
            .|          :.:||      |..:.|...|.                       ..::.||.
Mouse   860 SG----------YLLDL------GTCQMGAICKD-----------------------GEYIDDQG 885

  Fly  1106 ILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEARKDQRKEVNGPNAQITQWDMIF-------- 1162
              ..|....:.|....|.|     |:..:.|......|.|..:|.|:     |...|
Mouse   886 --HCQTCEASCAKCWGPTQ-----EDCISCPVTRVLDDGRCVMNCPS-----WKFEFKKQCHPCH 938

  Fly  1163 ---------------------YGTET----------------PAQ-------PDD---------- 1173
                                 :|.|.                ||:       ||:
Mouse   939 YTCQGCQGSGPSNCTSCRADKHGQERFLYHGECLENCPVGHYPAKGHACLPCPDNCELCYNPHVC 1003

  Fly  1174 --------VANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDR 1230
                    :..|:.:.| .|........|.||:.....    :.|.:|.|.|....
Mouse  1004 SRCMSGYVIIPPNHTCQ-KLECRQGEFQDSEYEECMPC----EEGCLGCTEDDPGA--------- 1054

  Fly  1231 KCLECNDSAYMFEDQCYDVCPVHTYPLDKFQAEEDEQDDEVTRGPVNPYSSSPMDHSLLMS--NS 1293
             |..|....||||..||..||..|:.: |::.    :......|..:.:.....:....:|  :.
Mouse  1055 -CTSCATGYYMFERHCYKACPEKTFGV-KWEC----RACGTNCGSCDQHECYWCEEGFFLSGGSC 1113

  Fly  1294 LDDKQDPLQAEDRRRRSSLTQLVEVPSRVCAACDRSCLECYGALASQCSTCSPGSQL 1350
            :.|.......:.        :|.|     |..|.|:|..|.|:..:|||:|..|.||
Mouse  1114 VQDCGPGFHGDQ--------ELGE-----CKPCHRACENCTGSGYNQCSSCQEGLQL 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	30/78 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	193/293 (66%)
		Peptidase_S8	363..646	CDD:278510	184/282 (65%)
		P_proprotein	701..787	CDD:279782	38/89 (43%)
		FU	1320..>1350	CDD:214589	11/29 (38%)
Pcsk5	NP_001177412.1	S8_pro-domain	40..116	CDD:293079	30/78 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	128..422	CDD:173789	193/293 (66%)
		Peptidase_S8	164..447	CDD:278510	184/282 (65%)
		P_proprotein	507..597	CDD:279782	38/89 (43%)
		Cell attachment site. /evidence=ECO:0000255	521..523		1/1 (100%)
		FU 1	632..682		11/49 (22%)
		FU	637..687	CDD:238021	10/49 (20%)
		CRM (Cys-rich motif)	638..1753		110/656 (17%)
		FU	690..739	CDD:238021	8/48 (17%)
		Furin-like_2	695..786	CDD:292535	19/124 (15%)
		FU	781..825	CDD:214589	8/43 (19%)
		GF_recep_IV	786..906	CDD:291509	27/183 (15%)
		FU	835..880	CDD:214589	12/101 (12%)
		FU	885..928	CDD:214589	11/54 (20%)
		FU	931..980	CDD:214589	2/48 (4%)
		FU	1036..1078	CDD:214589	14/55 (25%)
		Furin-like_2	1043..1130	CDD:292535	21/114 (18%)
		FU	1128..1165	CDD:214589	14/35 (40%)
		FU	1211..1256	CDD:238021
		Furin-like_2	1214..1305	CDD:292535
		FU	1301..1343	CDD:214589
		Furin-like_2	1357..1445	CDD:292535
		FU	1397..1446	CDD:238021
		FU	1491..1535	CDD:214589
		GF_recep_IV	1496..1611	CDD:291509
		FU	1546..1593	CDD:238021
		FU	1594..1644	CDD:238021
		GF_recep_IV	1595..1712	CDD:291509
		FU	1642..1684	CDD:214589
		FU	1694..1736	CDD:214589
		AC 1	1825..1844
		AC 2	1856..1877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820