DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and Pcsk2

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_032818.1	Gene:	Pcsk2 / 18549	MGIID:	97512	Length:	637	Species:	Mus musculus

Alignment Length:	580	Identity:	270/580 - (46%)
Similarity:	368/580 - (63%)	Gaps:	35/580 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGF-VNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDR 294
            :|:.:.|.:.......|..||.:||| |......:..|||.|:.::|.....:.||:.:|:.|.|
Mouse    29 FTNHFLVELHKDGEEEARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKRQLERDPR 93

  Fly   295 VHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGG------GLDMNV 353
            :..|.||....|.||.:          |.::.:| ::.||..:.:.|||...|      |||:||
Mouse    94 IKMALQQEGFDRKKRGY----------RDINEID-INMNDPLFTKQWYLFNTGQADGTPGLDLNV 147

  Fly   354 IPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDS--NRHGTR 416
            ..||::|.|||||.:.|:|||::..|||:..||:..||||.:|:|..|.|.|  ||.  |.||||
Mouse   148 AEAWELGYTGKGVTIGIMDDGIDYLHPDLAYNYNADASYDFSSNDPYPYPRY--TDDWFNSHGTR 210

  Fly   417 CAGEVAATANNSFCAVGIAYGASVGGVRMLDGD-VTDAVEARSLSLNPQHIDIYSASWGPDDDGK 480
            |||||:|.|:|:.|.||:||.:.|.|:||||.. :||.:||.|:|..||.||||||||||.|:||
Mouse   211 CAGEVSAAASNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGK 275

  Fly   481 TVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHV 545
            |||||.||..:|..:|..|||||||||::||||:|| ..|:||||||.:|:||:||:||..:|..
Mouse   276 TVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGG-SYDDCNCDGYASSMWTISINSAINDGRT 339

  Fly   546 PWYSEKCSSTLATTYSSGGQ--GEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLT 608
            ..|.|.||||||:|:|:|.:  .|..|.||||:.:||:.|:||||:||.|||:.||.|::|.:||
Mouse   340 ALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLDLT 404

  Fly   609 WRDLQHIVVRTAKPANLKDP--SWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEI 671
            |||:||:.|.|:|...|.|.  .|.|||||...:|.||||::||..||::|::||.|||:..|..
Mouse   405 WRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVG 469

  Fly   672 NAPHVDKVIPPRTHITLQLTVNHCRS----VNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTL 732
            .:....:.|||...:.|.|..|.|..    |.|||||||.||:.:.||||:.:.:.||..|...|
Mouse   470 GSVQNPEKIPPTGKLVLTLKTNACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSIL 534

  Fly   733 LT--PRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGT 790
            |:  || .|:|:.||::||||:.|||||..:|.|.||:...|......||:||:|:.:||
Mouse   535 LSRRPR-DDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGLLKEWTLMLHGT 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	22/75 (29%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	165/299 (55%)
		Peptidase_S8	363..646	CDD:278510	162/289 (56%)
		P_proprotein	701..787	CDD:279782	42/87 (48%)
		FU	1320..>1350	CDD:214589
Pcsk2	NP_032818.1	S8_pro-domain	32..108	CDD:293079	22/75 (29%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	121..417	CDD:173789	165/298 (55%)
		Peptidase_S8	157..434	CDD:278510	157/279 (56%)
		P_proprotein	503..590	CDD:279782	42/87 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840