DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and Pcsk1

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_038656.1	Gene:	Pcsk1 / 18548	MGIID:	97511	Length:	753	Species:	Mus musculus

Alignment Length:	763	Identity:	327/763 - (42%)
Similarity:	436/763 - (57%)	Gaps:	143/763 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKI--FDDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            :.:.||..||.|... |.|:|::.|:..||:|  .::||.|.|....:||...|.|...||.|||
Mouse    31 FVNEWAAEIPGGQEA-ASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITKRLSDDD 94

  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRG------GGLDMN 352
            ||.||:||..|.||||          |.:..|.:|.  |||..|.|.|||...      ..||::
Mouse    95 RVTWAEQQYEKERSKR----------SVQKDSALDL--FNDPMWNQQWYLQDTRMTAALPKLDLH 147

  Fly   353 VIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRC 417
            |||.|:.||||||||:|:||||||.:|.||..||||:||||.|.:|.||.|.||:|:.|:|||||
Mouse   148 VIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRC 212

  Fly   418 AGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTV 482
            |||:|..|||..|.||:||.:.|||:|||||.||||:||.|:..||.|:|||||||||:||||||
Mouse   213 AGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTV 277

  Fly   483 DGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPW 547
            :|||.||.:||..|..:||.||||||:||||||||:.|||:|||||:||:|:|||||:::|..||
Mouse   278 EGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPW 342

  Fly   548 YSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDL 612
            |:|||||||||:||||...::::.:.|||:.||.:||||||||||||||.||.|::|.||||||:
Mouse   343 YAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDM 407

  Fly   613 QHIVVRTAKPANL-KDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVA--RNWKAVPEQQRCEINAP 674
            ||:||.|::...| .:|.|.:||.|..|:..||:||::|..:|.:|  |.|:.|||::.|.:.
Mouse   408 QHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVK-- 470

  Fly   675 HVDKVIPPRT-----HITLQLTVNHC----RSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSV 730
              |....||.     .:.:::....|    .::..|||||.:.|:...||||:.:.|.|...||.
Mouse   471 --DNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTST 533

  Fly   731 TLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEI-------HNEGRYMGHALLREWSLIFY 788
            .||..|..|.|.:||..|.|||||||||:|.|.|.|:|       .||||.:      .|.||.:
Mouse   534 VLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITDMSGRMQNEGRIV------NWKLILH 592

  Fly   789 GTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKV 853
            ||                         ||...::.|      ||:
Mouse   593 GT-------------------------SSQPEHMKQ------PRV-------------------- 606

  Fly   854 PPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNGN---- 914
                   |.:.|.:.|.   ::|.:::.                |..||...:  ||.|||
Mouse   607 -------YTSYNTVQND---RRGVEKMV----------------NVVEKRPTQ--KSLNGNLLVP 643

  Fly   915 KGKSGGSSGNRKEQTTQST-------IIQTSTSKNKYYRISQQQQQKN 955
            |..|..:...|:::..|.|       ::|::.|||   .:|:|..:|:
Mouse   644 KNSSSSNVEGRRDEQVQGTPSKAMLRLLQSAFSKN---ALSKQSPKKS 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	34/76 (45%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	190/294 (65%)
		Peptidase_S8	363..646	CDD:278510	182/283 (64%)
		P_proprotein	701..787	CDD:279782	42/92 (46%)
		FU	1320..>1350	CDD:214589
Pcsk1	NP_038656.1	S8_pro-domain	34..110	CDD:374560	34/76 (45%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	121..415	CDD:173789	189/293 (65%)
		P_proprotein	504..591	CDD:366670	42/92 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..663		9/31 (29%)
		Proho_convert	715..751	CDD:371942
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750