DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and egl-3

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001023732.1	Gene:	egl-3 / 179412	WormBaseID:	WBGene00001172	Length:	652	Species:	Caenorhabditis elegans

Alignment Length:	647	Identity:	280/647 - (43%)
Similarity:	376/647 - (58%)	Gaps:	76/647 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADA--VAKDHGFVNLGKI--FDDHYHFAH----HKVSKRSLSPATHHQT 287
            ||:.:.||:..| .|:.||  :||.|||:|.|::  .|:.|||..    |..::||   |.|| .
Worm    26 YTNHFHVHLKEG-GGLEDAHRIAKRHGFINRGQVAASDNEYHFVQPALVHARTRRS---AGHH-A 85

  Fly   288 RLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVD---AMSFNDSKWPQMWYL-NRG-- 346
            :|.:||.|...:|.:..:|:||.:   ||  ...|..|..|   .||.:|..:...||| |.|
Worm    86 KLHNDDEVLHVEQLKGYTRTKRGY---RP--LEQRLESQFDFSAVMSPSDPLYGYQWYLKNTGQA 145

  Fly   347 GG---LDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMT 408
            ||   ||:||..||.||.|||.:...|:|||::..||||::|::.:||||.:|:|..|.|.|  |
Worm   146 GGKARLDLNVERAWAMGFTGKNITTAIMDDGVDYMHPDIKNNFNAEASYDFSSNDPFPYPRY--T 208

  Fly   409 DS--NRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGD-VTDAVEARSLSLNPQHIDIYS 470
            |.  |.||||||||:.|..:|..|.||:||...|.|:||||.. :||.:||.|:...|..|.|||
Worm   209 DDWFNSHGTRCAGEIVAARDNGVCGVGVAYDGKVAGIRMLDQPYMTDLIEANSMGHEPSKIHIYS 273

  Fly   471 ASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLS 535
            |||||.|||||||||.....||.:.|..:||.|.||||:||||:|| |.|:||||||..|:||:|
Worm   274 ASWGPTDDGKTVDGPRNATMRAIVRGVNEGRNGLGSIFVWASGDGG-EDDDCNCDGYAASMWTIS 337

  Fly   536 ISSATEEGHVPWYSEKCSSTLATTYSSGGQG-EKQVVTTDLHHSCTVSHTGTSASAPLAAGIAAL 599
            |:||...|....|.|.||||||:|:|:||:. |..|.||||:..||.||:||||:||.|||:.||
Worm   338 INSAINNGENAHYDESCSSTLASTFSNGGRNPETGVATTDLYGRCTRSHSGTSAAAPEAAGVFAL 402

  Fly   600 VLQSNQNLTWRDLQHIVVRTAKPANLKD------PS------------------WSRNGVGRRVS 640
            .|::|.:||||||||:.|.|:...:|.|      ||                  |..||||...:
Worm   403 ALEANPSLTWRDLQHLTVLTSSRNSLFDGRCRDFPSLGINDNHRDSHGNCSHFEWQMNGVGLEYN 467

  Fly   641 HSFGYGLMDAAEMVRVARNWKAVPEQQRCE---INAPHVDKVIPPRTHITLQLTVNHCR----SV 698
            |.||:|::||||||.:|..||..|.:..|.   |:.||   .||...::.|::..:.|.    .|
Worm   468 HLFGFGVLDAAEMVMLAMAWKTSPPRYHCTAGLIDTPH---EIPADGNLILEINTDGCAGSQFEV 529

  Fly   699 NYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPR-IHDNSRSGFNQWPFMSVHTWGESPQG 762
            .|||||||.::..|.||||..|:|.||..|...:|:.| ..|:|:.||..||||:.|||||:|.|
Worm   530 RYLEHVQAVVSFNSTRRGDTTLYLISPMGTRTMILSRRPKDDDSKDGFTNWPFMTTHTWGENPTG 594

  Fly   763 NWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQ 824
            .|:|....:|.......|:::.|:.:||.::     |.::.:|...:  |.....|....|:
Worm   595 KWRLVARFQGPGAHAGTLKKFELMLHGTREA-----PYNLIEPIVGQ--TNKKLDTVQKAHK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	29/82 (35%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	162/298 (54%)
		Peptidase_S8	363..646	CDD:278510	157/310 (51%)
		P_proprotein	701..787	CDD:279782	38/86 (44%)
		FU	1320..>1350	CDD:214589
egl-3	NP_001023732.1	S8_pro-domain	29..107	CDD:318632	29/82 (35%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	128..423	CDD:173789	161/297 (54%)
		P_proprotein	532..619	CDD:307572	38/86 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920