DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and kpc-1

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_492974.2	Gene:	kpc-1 / 173051	WormBaseID:	WBGene00002232	Length:	692	Species:	Caenorhabditis elegans

Alignment Length:	624	Identity:	344/624 - (55%)
Similarity:	411/624 - (65%)	Gaps:	45/624 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIF--DDHYHFA-HHKVSKRSLSPATHHQTRLDDD 292
            ||:.|||.|..|....|:.:|..:|:.|||.|.  |::|.|. ..|.|:.|....:....:|..:
Worm    58 YTNEWAVRIAGGKVEEANRLANKYGYTNLGPIIPGDEYYLFRDDRKKSRSSRKTRSLSANQLQHE 122

  Fly   293 DRVHWAKQQRAKSRSKRDFIRMR---------------PSRTSSRAMSMVDAMSFNDSKWPQMWY 342
            :.|.|.:||.||.|.||.:.|:|               ...:.||.....|.   ||..|..|||
Worm   123 EDVMWMEQQVAKRRVKRGYRRIRRHTDDNDIFEEDDDGTQISKSRNRKHPDP---NDPLWTDMWY 184

  Fly   343 LNRG-------GGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDD 400
            ||||       ..:|.||..||.:|.|||||||||||||||..||||..|||.:||||||..|:|
Worm   185 LNRGEHHSDSTTRMDHNVKEAWDLGYTGKGVVVTILDDGLERTHPDISPNYDERASYDVNDRDND 249

  Fly   401 PMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQH 465
            |||.|:.:|.|||||||||||||..|||.|.|||||.|::||:|||||||||||||.|:..|..:
Worm   250 PMPRYEFSDENRHGTRCAGEVAAIFNNSLCIVGIAYNANIGGIRMLDGDVTDAVEAASVGHNADY 314

  Fly   466 IDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNS 530
            ||||||||||||||:|||||.:|...||.:|.|.||.||||||:|||||||::.|:|||||||||
Worm   315 IDIYSASWGPDDDGRTVDGPAKLTRSAFEKGITMGRKGKGSIFVWASGNGGKDADSCNCDGYTNS 379

  Fly   531 IWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAG 595
            |:|||||||||.|::|||||.||||||||||||..|||.::||||||:||..|||||||||||||
Worm   380 IYTLSISSATENGNIPWYSEACSSTLATTYSSGATGEKMILTTDLHHACTNMHTGTSASAPLAAG 444

  Fly   596 IAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNW 660
            |.||.|::|.|||||||||||:|||||.||:...|:.|||||.||||||||||||..||::|:.|
Worm   445 IVALALEANPNLTWRDLQHIVIRTAKPINLRAGDWTTNGVGRNVSHSFGYGLMDAGAMVKLAKIW 509

  Fly   661 KAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHC------RSVNYLEHVQAKITLTSQRRGDIQ 719
            |.|.||.||....|...|.||....:.|||..:.|      ..|:|:|||||.:||.:.:|||:|
Worm   510 KKVDEQHRCRQFYPSRYKNIPNGNRLQLQLYSDGCYGGADENKVSYVEHVQAIVTLKAPKRGDLQ 574

  Fly   720 LFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWS 784
            ::|.||:.|..||||.|..|.|||||..|.||:.|.|||...|.|.|||.|:|  ...|.|.:|.
Worm   575 IYLTSPSGTKSTLLTKRARDTSRSGFTDWAFMTTHNWGEQAAGLWILEIDNDG--WDDAELVKWE 637

  Fly   785 LIFYGTTQSIGP-----NDPISVPKPSGSEATTPNSSST 818
            |:.|||.:..|.     ..|::| :....|||   ||.|
Worm   638 LVLYGTDRETGDFGGQHASPLAV-RSVQMEAT---SSGT 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	26/77 (34%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	210/295 (71%)
		Peptidase_S8	363..646	CDD:278510	210/282 (74%)
		P_proprotein	701..787	CDD:279782	44/85 (52%)
		FU	1320..>1350	CDD:214589
kpc-1	NP_492974.2	S8_pro-domain	61..139	CDD:318632	26/77 (34%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	174..470	CDD:173789	210/298 (70%)
		P_proprotein	556..640	CDD:307572	44/85 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	455	1.000	Domainoid score	I251
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	1	1.000	-	-		oto17188
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	LDO	PTHR42884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R643
SonicParanoid	1	1.000	-	-		X2431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.950