DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fur1 and bli-4

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_001021543.1	Gene:	bli-4 / 172333	WormBaseID:	WBGene00000254	Length:	942	Species:	Caenorhabditis elegans

Alignment Length:	657	Identity:	301/657 - (45%)
Similarity:	386/657 - (58%)	Gaps:	58/657 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 GHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            |...|| .:.:...|:.:|..:|.||.....|..|.|.::|.:|..:.|:.........|||...
Worm    37 GEPIHT-VIRLAKRDDELARRIAADHDMHVKGDPFLDTHYFLYHSETTRTRRHKRAIVERLDSHP 100

  Fly   294 RVHWAKQQRAKSRSKRDFIRM---------------------RPSRTSSRAMSMVDAMSFNDSKW 337
            .|.|.::||.|.|.|||:|.:                     |..|...::...:.::.|.|..:
Worm   101 AVEWVEEQRPKKRVKRDYILLDNDVHHSNPFRRSVLNRDGTRRAQRQQPQSPREIPSLPFPDPLY 165

  Fly   338 PQMWYLNRG--GGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDD 400
            ...|||:.|  ||.||||..||..|..|:.|.|:|||||::.||||:..||||.||.|:|.||||
Worm   166 KDQWYLHGGAVGGYDMNVRQAWLQGYAGRNVSVSILDDGIQRDHPDLAANYDPLASTDINDHDDD 230

  Fly   401 PMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQH 465
            |.|..:  ..|:|||||||||||.|.|:.|.||:|:.|.:||||||||.|:|:|||.|||||..|
Worm   231 PTPQNN--GDNKHGTRCAGEVAALAGNNQCGVGVAFKAKIGGVRMLDGAVSDSVEAASLSLNQDH 293

  Fly   466 IDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNS 530
            ||||||||||:|||||.||||.||..||..|...||||||:||:|||||||..||:|:.||||.|
Worm   294 IDIYSASWGPEDDGKTFDGPGPLAREAFYRGIKNGRGGKGNIFVWASGNGGSRQDSCSADGYTTS 358

  Fly   531 IWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAG 595
            ::||||||||.:.|.|||.|:|.|::||||||....:..:||.|:...||..|||||||||||||
Worm   359 VYTLSISSATYDNHRPWYLEECPSSIATTYSSADFRQPAIVTVDVPGGCTDKHTGTSASAPLAAG 423

  Fly   596 IAALVLQSNQNLTWRDLQHIVVRTA--KPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVAR 658
            |.||.|::|..|||||:||:|:|||  ||.. .:|.||||||||.||:.|||||:|...:|.:|:
Worm   424 IIALALEANPELTWRDMQHLVLRTANWKPLE-NNPGWSRNGVGRMVSNKFGYGLIDGGALVNMAK 487

  Fly   659 NWKAVPEQQRC----EINAPHVDKVIPPRTHITLQLTVNHCRS---VNYLEHVQAKITLTSQRRG 716
            .||.||||..|    .:..|: .:.|..|..:...|.||.|.|   |.||||||...|:...:||
Worm   488 TWKTVPEQHICTYEYRLANPN-PRPIVGRFQLNFTLDVNGCESGTPVLYLEHVQVHATVRYLKRG 551

  Fly   717 DIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHN-------EGRY 774
            |::|.|.||:.|...||.||..|.:.:||::|||:||..|||.|:|.|.|.:.:       .|.:
Worm   552 DLKLTLFSPSGTRSVLLPPRPQDFNANGFHKWPFLSVQQWGEDPRGTWLLMVESVTTNPAATGTF 616

  Fly   775 MGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFG 839
                  .:|:|:.|||.......||:       ..||...|....|.:||..| |.....|.:|.
Worm   617 ------HDWTLLLYGTADPAQSGDPV-------YSATPATSQGVLSRVHQLTS-QVEESAPISFP 667

  Fly   840 SSPSGGS 846
            ...|.|:
Worm   668 DLTSAGN 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	21/74 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	181/292 (62%)
		Peptidase_S8	363..646	CDD:278510	181/284 (64%)
		P_proprotein	701..787	CDD:279782	36/92 (39%)
		FU	1320..>1350	CDD:214589
bli-4	NP_001021543.1	S8_pro-domain	43..116	CDD:318632	20/72 (28%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-lik	160..448	CDD:173789	179/289 (62%)
		P_proprotein	536..623	CDD:307572	36/92 (39%)
		FU	675..728	CDD:238021	301/657 (46%)
		VSP	716..>856	CDD:333463
		FU	804..847	CDD:214589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920