DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fur1 and Pcsk4

DIOPT Version :9

Sequence 1:	NP_001262954.1	Gene:	Fur1 / 47220	FlyBaseID:	FBgn0004509	Length:	1478	Species:	Drosophila melanogaster
Sequence 2:	NP_598243.1	Gene:	Pcsk4 / 171085	RGDID:	620325	Length:	654	Species:	Rattus norvegicus

Alignment Length:	663	Identity:	313/663 - (47%)
Similarity:	404/663 - (60%)	Gaps:	54/663 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 YTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIF--DDHYHFAHHKVSKRSLSPATHHQTRLDDDD 293
            |..:|||.:..|.. .|:.:|:..||||||:||  |.::|..|..|:::||:|...|:.||..:.
  Rat    31 YVSSWAVRVTKGYQ-EAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEP 94

  Fly   294 RVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWK 358
            :|.|.:||..:.|.||..:  .|:                |..:.:.||:|:....|:|::..|.
  Rat    95 KVRWFEQQTLRRRVKRSLV--VPT----------------DPWFSKQWYMNKEIEQDLNILKVWN 141

  Fly   359 MGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAA 423
            .|:||:||||:|||||:|.||||:..||||.||||.|.:|.||.|.|...|.|||||||||||:|
  Rat   142 QGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSA 206

  Fly   424 TANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGEL 488
            ||||.||..|:|:.|.:||||||||.:||.|||:||||.||||.||||||||:|||:||||||.|
  Rat   207 TANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLL 271

  Fly   489 ASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCS 553
            ...||..|.||||.|.|::|||||||||...||||||||||||.|||:.|.|.:|.||||||.|:
  Rat   272 TQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACA 336

  Fly   554 STLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVR 618
            ||..||:|||...:.|:|||||||.||..|||||||||||||:.||.|::|..||||||||:|||
  Rat   337 STFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVR 401

  Fly   619 TAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPR 683
            .::||.|:...|..|||||:|||.:||||:||..:|.:||.|.....|::|.|...|....|.||
  Rat   402 ASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPR 466

  Fly   684 THITLQLTV----NHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSG 744
            ..:...:||    :..|.:..|||||.:::|:..||||:::||.||..|..||:..|..|.|..|
  Rat   467 MLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQG 531

  Fly   745 FNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSE 809
            :|.|.|||.|.|.|.|||.|.|.:.|:|.|.....|...:|:.|||.:.:
  Rat   532 YNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDM--------------- 581

  Fly   810 ATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKLPL--GK-VPPPNKSSYVTNNPLLNSA 871
            ...|.:...||..|.........:|         |.|..||  |: :|...::..|...|  ::|
  Rat   582 TARPQTPQVTSCAHACAEGHRGAVP---------GKSLSPLHCGRTLPHLQQAVVVALQP--HTA 635

  Fly   872 PPKQGYQQISATY 884
            ...||..|:|.:|
  Rat   636 ASDQGTGQLSPSY 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fur1	NP_001262954.1	S8_pro-domain	234..309	CDD:293079	29/76 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	332..621	CDD:173789	187/288 (65%)
		Peptidase_S8	363..646	CDD:278510	191/282 (68%)
		P_proprotein	701..787	CDD:279782	39/85 (46%)
		FU	1320..>1350	CDD:214589
Pcsk4	NP_598243.1	S8_pro-domain	34..110	CDD:293079	29/76 (38%)
		Peptidases_S8_Protein_convertases_Kexins_Fur in-like	115..404	CDD:173789	188/304 (62%)
		Peptidase_S8	146..419	CDD:278510	184/272 (68%)
		P_proprotein	488..567	CDD:279782	37/78 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7592
eggNOG	1	0.900	-	-		E1_COG1404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D311719at33208
OrthoFinder	1	1.000	-	-		FOG0000204
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100362
Panther	1	1.100	-	-	O	PTHR42884
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2431
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.780